Introduction
Subjects and methods
Cardiovascular risk factor measurements at 1998–2000
Follow-up
Statistical methods
Study population
Results
Serum magnesium (mmol/L) quintiles | p-trend across quintiles | |||||
---|---|---|---|---|---|---|
1 (< 0.75) | 2 (0.75–0.79) | 3 (0.80–0.82) | 4 (0.83–0.86) | 5 (≥ 0.87) | ||
No of men | 610 | 807 | 688 | 748 | 670 | |
Age (yrs) | 68.9 (5.55) | 68.5 (5.60) | 68.6 (5.49) | 68.5 (5.37) | 68.2 (5.58) | 0.16 |
% smokers | 14.6 | 12.9 | 13.0 | 11.8 | 12.1 | 0.14 |
% manual | 54.9 | 54.5 | 55.4 | 53.6 | 48.8 | 0.03 |
% inactive | 11.6 | 11.1 | 8.1 | 9.3 | 9.7 | 0.13 |
% heavy drinkers | 4.8 | 4.1 | 4.8 | 3.3 | 2.5 | 0.03 |
% diabetes | 18.7 | 13.4 | 12.1 | 10.0 | 8.7 | < 0.001 |
% AF | 3.9 | 3.7 | 4.4 | 2.0 | 2.1 | 0.01 |
% use of antihypertensive drugs | 33.0 | 28.0 | 22.5 | 24.5 | 28.7 | 0.03 |
diuretics | 11.2 | 8.4 | 4.9 | 4.9 | 4.8 | < 0.001 |
% LVH | 7.5 | 7.9 | 7.7 | 7.1 | 8.4 | 0.84 |
% renal dysfunction | 13.7 | 12.9 | 12.9 | 15.1 | 17.5 | 0.01 |
% ECG ischaemia | 24.9 | 24.6 | 22.2 | 20.3 | 19.7 | 0.003 |
BMI (kg/m2) | 26.9 (3.87) | 27.0 (3.57) | 26.7 (3.56) | 26.9 (3.61) | 26.4 (3.24) | 0.004 |
Heart rate (beats/min) | 68.3 (14.3) | 66.2 (12.0) | 65.3 (12.39) | 65.6 (13.22) | 64.1 (11.17) | < 0.001 |
SBP (mmHg) | 150.1 (23.8) | 149.0 (23.6) | 149.2 (24.0) | 151.3 (23.8) | 151.2 (24.4) | 0.09 |
HDL-C (mmol/l) | 1.36 (0.36) | 1.33 (0.34) | 1.31 (0.32) | 1.33 (0.35) | 1.32 (0.34) | 0.02 |
Cholesterol (mmol/l) | 5.91 (1.06) | 6.00 (1.07) | 6.03 (1.05) | 6.16 (1.08) | 6.12 (1.03) | < 0.001 |
HOMA | 0.88 (0.81) | 0.83 (0.76) | 0.74 (0.71) | 0.75 (0.66) | 0.73 (0.71) | < 0.001 |
eGFR (ml/min per 1.73 m2) | 73.3 (12.04) | 72.7 (11.97) | 73.52 (12.87) | 72.2 (12.15) | 70.83 (13.4) | 0.0004 |
FEV1 (L) | 2.55 (0.67) | 2.59 (0.65) | 2.64 (0.67) | 2.66 (0.64) | 2.65 (0.68) | 0.001 |
CRP (mg/L)* | 1.88 (0.82, 3.93) | 1.73 (0.90, 3.49) | 1.62 (0.78, 3.21) | 1.55 (0.75, 3.00) | 1.67 (0.80, 3.18) | 0.01 |
IL6 (mg/L) | 2.59 (1.66, 3.71) | 2.48 (1.58, 3.40) | 2.41 (1.57, 3.41) | 2.27 (1.53, 3.14) | 2.22 (1.42, 3.07) | < 0.001 |
vWF (IU/dL) | 140.4 (48.4) | 140.5 (48.4) | 138.5 (44.8) | 137.5 (43.9) | 134.0 (43.7) | < 0.001 |
NT-proBNP (pg/ml)* | 99.5 (44–201) | 86.5 (43–172) | 90.0 (47–162) | 81.5 (39–148) | 88.2 (41–165) | 0.04 |
cTnT (pg/ml)* | 12.55 (9.3, 16.6) | 11.70 (8.4, 15.0) | 11.02 (8.2, 14.6) | 11.70 (8.7, 15.6) | 11.47 (8.3, 15.6) | 0.003 |
Calcium (mmol/L) | 2.41 (0.10) | 2.42 (0.09) | 2.43 (0.09) | 2.44 (0.09) | 2.45 (0.10) | < 0.001 |
Phosphate (mmol/L) | 1.13 (0.16) | 1.16 (0.15) | 1.15 (0.15) | 1.15 (0.15) | 1.18 (0.16) | < 0.001 |
Potassium (mmol/L) | 4.36 (0.36) | 4.41 (0.37) | 4.45 (0.35) | 4.44 (0.36) | 4.47 (0.36) | < 0.001 |
All men (N = 3523) | No CKD (N = 3505) | |||
---|---|---|---|---|
r
|
p
|
r
|
p
| |
eGFR (ml/min per 1.73 m2) | − 0.07 | < 0.0001 | − 0.06 | 0.001 |
FEV1 (L) | 0.07 | 0.0002 | 0.06 | 0.0008 |
HOMA-IR | − 0.06 | 0.0005 | − 0.06 | 0.001 |
CRP (mg/L) | − 0.03 | 0.16 | − 0.02 | 0.22 |
IL-6 | − 0.09 | < 0.0001 | − 0.08 | < 0.0001 |
vWF | − 0.05 | 0.004 | − 0.04 | 0.04 |
Heart rate (b/min) | − 0.11 | < 0.0001 | − 0.10 | < 0.0001 |
NT-proBNP (pg/ml) | − 0.04 | 0.02 | − 0.05 | 0.006 |
cTnT | − 0.06 | 0.0006 | − 0.07 | 0.0002 |
Serum magnesium and incident coronary heart disease
Serum magnesium and incident heart failure
Serum magnesium (mmol/L) quintiles | P-trend | ||||||
---|---|---|---|---|---|---|---|
1 (< 0.75) | 2 (0.75–0.79) | 3 (0.80–0.82) | 4 (0.83–0.86) | 5 (≥ 0.87) | HR 1SD increase in Mg | ||
No of men | 610 | 807 | 688 | 748 | 670 | ||
Rate/1000 per-yrs (n) | 7.9 (56) | 6.7 (65) | 5.8 (48) | 6.7 (60) | 4.9 (39) | ||
Age | 1.00 | 0.75 (0.52, 1.08) | 0.76 (0.51, 1.10) | 0.70 (0.49, 1.01) | 0.50 (0.33, 0.76) | 0.84 (0.74, 0.95) | 0.004 |
Model 1 | 1.00 | 0.74 (0.51, 1.07) | 0.85 (0.57, 1.25) | 0.77 (0.53, 1.14) | 0.56 (0.36, 0.87) | 0.88 (0.77, 0.99) | 0.04 |
Exclude men with diuretics | 1.00 | 0.72 (0.48, 1.08) | 0.89 (0.59, 1.36) | 0.79 (0.53, 1.19) | 0.57 (0.36, 0.90) | 0.86 (0.75, 0.98) | 0.03 |
Model 1 +incident MI | 1.00 | 0.72 (0.50, 1.05) | 0.85 (0.59, 1.26) | 0.76 (0.52, 1.11) | 0.56 (0.36, 0.86) | 0.87 (0.77, 0.98) | 0.03 |
Model 2 | 1.00 | 0.72 (0.50, 1.05) | 0.84 (0.57, 1.25) | 0.79 (0.54, 1.16) | 0.58 (0.37, 0.90) | 0.89 (0.78, 1.01) | 0.07 |
Model 3 | 1.00 | 0.74 (0.51, 1.07) | 0.84 (0.57, 1.25) | 0.81 (0.55, 1.19) | 0.60 (0.38, 0.93) | 0.90 (0.79, 1.02) | 0.10 |
Model 4 | 1.00 | 0.75 (0.52, 1.10) | 0.85 (0.58, 1.26) | 0.83 (0.57, 1.23) | 0.62 (0.40, 0.97) | 0.91 (0.80, 1.04) | 0.16 |
Model 5 | 1.00 | 0.74 (0.51, 1.07) | 0.92 (0.62, 1.36) | 0.86 (0.58, 1.27) | 0.65 (0.41, 1.00) | 0.93 (0.81, 1.05) | 0.24 |
Model 6 | 1.00 | 0.79 (0.54, 1.13) | 0.94 (0.63, 1.40) | 0.97 (0.65, 1.43) | 0.70 (0.45, 1.10) | 0.95 (0.84, 1.08) | 0.17 |
Model 6 (N = 3017;exclude men with CKD) | 1.00 | 0.78 (0.52, 1.18) | 0.78 (0.50, 1.23) | 0.92 (0.59, 1.42) | 0.59 (0.35, 0.98) | 0.91 (0.79, 1.04) | 0.17 |
Serum magnesium (mmol/L) quintiles | p-trend | |||||
---|---|---|---|---|---|---|
1 (< 0.75) | 2 (0.75–0.79) | 3 (0.80–0.82) | 4 (0.83–0.86) | 5 (≥ 0.87) | ||
Men with no ischaemia (N = 2731) | ||||||
No of men (cases) | 458 (30) | 609 (43) | 535 (32) | 594 (39) | 535 (26) | |
Model 1 | 1.00 | 0.93 (0.58, 1.51) | 1.02 (0.62, 1.69) | 0.91 (0.55, 1.49) | 0.79 (0.46, 1.36) | 0.36 |
Model 1 +incident MI | 1.00 | 0.93 (0.57, 1.51) | 1.03 (0.62, 1.71) | 0.87 (0.53, 1.44) | 0.80 (0.47, 1.38) | 0.38 |
Men with ischaemia (N = 783) | ||||||
No of men (cases) | 152 (26) | 197 (22) | 152 (16) | 151 (21) | 131 (13) | |
Model 1 | 1.00 | 0.49 (0.27, 0.89) | 0.65 (0.35, 1.24) | 0.63 (0.35, 1.24) | 0.29 (0.13, 0.68) | 0.03 |
Model 1 +incident MI | 1.00 | 0.46 (0.25, 0.84) | 0.64 (0.34, 1.22) | 0.65 (0.35, 1.19) | 0.28 (0.12, 0.65) | 0.04 |