Serum matrix metalloproteinase-9 as a predictor of recurrence in idiopathic nephrotic syndrome
- 27.05.2025
- Original article
Erschienen in:
- Verfasst von
- Masahiko Ochi
- Akinori Hara
- Shiori Nakagawa
- Megumi Oshima
- Shinji Kitajima
- Tadashi Toyama
- Norihiko Sakai
- Miho Shimizu
- Yasunori Iwata
- Takashi Wada
- Erschienen in
- Clinical and Experimental Nephrology | Ausgabe 11/2025
Abstract
Background
The risk factors for the recurrence of idiopathic nephrotic syndrome (INS) remain unknown. Previous studies have suggested a potential link between matrix metalloproteinase-9 (MMP-9) and urinary protein levels in INS. Therefore, we aimed to investigate the association between serum MMP-9 levels and the risk of subsequent recurrence in patients with INS.
Methods
This retrospective study included 29 patients with biopsy-proven INS from 1998 to 2016. Baseline serum MMP-9 levels during the nephrotic phase were measured using an enzyme-linked immunosorbent assay. Subsequent recurrence was defined as a change in urinary protein levels from remission to more than 2 + on a dipstick test or more than 1 g/g creatinine.
Results
The median age was 42 years (interquartile range: 26.0, 70.0), and 18 patients were males. Over a median follow-up period of 130 days, 12 patients (41.4%) experienced recurrences. Patients who experienced recurrence were younger and had higher estimated glomerular filtration rates and baseline serum MMP-9 levels during the nephrotic phase than those who did not. Higher baseline serum MMP-9 levels during the nephrotic phase were associated with a higher risk of subsequent recurrence (hazard ratio: 5.687, 95% confidence interval: 1.179–27.44).
Conclusion
Baseline serum MMP-9 levels during the nephrotic phase were associated with subsequent recurrence in patients with INS, indicating its potential as a predictive marker for future recurrence in patients with INS.
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- Titel
- Serum matrix metalloproteinase-9 as a predictor of recurrence in idiopathic nephrotic syndrome
- Verfasst von
-
Masahiko Ochi
Akinori Hara
Shiori Nakagawa
Megumi Oshima
Shinji Kitajima
Tadashi Toyama
Norihiko Sakai
Miho Shimizu
Yasunori Iwata
Takashi Wada
- Publikationsdatum
- 27.05.2025
- Verlag
- Springer Nature Singapore
- Erschienen in
-
Clinical and Experimental Nephrology / Ausgabe 11/2025
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799 - DOI
- https://doi.org/10.1007/s10157-025-02704-w
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