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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Italian Journal of Pediatrics 1/2014

Serum trace elements in obese Egyptian children: a case–control study

Zeitschrift:
Italian Journal of Pediatrics > Ausgabe 1/2014
Autoren:
Seham FA Azab, Safaa H Saleh, Wafaa F Elsaeed, Mona A Elshafie, Laila M Sherief, Asmaa MH Esh
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1824-7288-40-20) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SFA designed the study, collected samples, performed the statistical analysis, wrote discussion, and submitted the manuscript. SS and WE reviewed the results and discussion. ME and LS participated in the design of the study and helped to draft the manuscript. A E conceived of the study and coordinated the sample collection and analysis. All authors read and approved all the manuscript.

Abstract

Background

To date, only a few studies on child obesity concerned Trace Elements (TE). TE is involved in the pathogenesis of obesity and obesity related diseases. We tried to assess trace elements status [zinc (Zn), copper (Cu), selenium (Se), iron (Fe), and chromium (Cr)] in obese Egyptian children and their relationships with serum leptin and metabolic risk factors of obesity.

Methods

This was a case–control study performed with 80 obese children (BMI ≥ 95thcentile for age and gender) and 80 healthy non-obese children with comparable age and gender as the control group. For all subjects, serum Zn, Cu, Se, Fe, ferritin and Cr as well as biochemical parameters including lipid profile, serum glucose and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed. Levels of serum leptin were measured by (enzyme-linked immunosorbent assay [ELISA] method), and serum insulin was measured by an electrochemiluminesce immunoassay.

Results

Compared to the control group, serum Zn, Se, and Fe levels were significantly lower (all P < 0.01) and serum Cu level was significantly higher (P < 0.01) in the obese children. Meanwhile, no significant differences were observed in serum ferritin or Cr levels (P > 0.05). A significant negative correlation was found between serum leptin and zinc levels in the obese children (r = −0.746; P < 0.01). Further, serum Zn showed significant negative correlations with total cholesterol TC levels (P < 0.05) and were positively correlated with high density lipoprotein- cholesterol HDL-C levels (P < 0.01) in the obese children. In addition, serum Se levels showed significant positive correlations with HOMA-IR values in the obese children (P < 0.01).

Conclusion

The obese children may be at a greater risk of developing imbalance (mainly deficiency) of trace elements which may be playing an important role in the pathogenesis of obesity and related metabolic risk factors.
Zusatzmaterial
Authors’ original file for figure 1
13052_2013_347_MOESM1_ESM.pdf
Authors’ original file for figure 2
13052_2013_347_MOESM2_ESM.docx
Authors’ original file for figure 3
13052_2013_347_MOESM3_ESM.docx
Literatur
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