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Erschienen in: Journal of Natural Medicines 3/2019

Open Access 19.02.2019 | Original Paper

Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa

verfasst von: Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2019

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Abstract

Three new sesquiterpenes, phlebidiol, phlebioic acid, and phlebiolide, as well as the known compound tremetriol, were isolated from cultures of the basidiomycete Phlebia tremellosa. The structures of all isolated compounds were established by extensive spectroscopic analyses, including those involving extensive two-dimensional nuclear magnetic resonance. The absolute configurations of phlebidiol, phlebioic acid, and phlebiolide were determined by comparisons of experimental and calculated electronic circular dichroism spectra. Phlebidiol and phlebioic acid have previously unreported carbon skeletons, for which we propose the skeletal names “seco-sterpurane” and “phlebiane,” respectively. Phlebiolide is also the second published example of a merulane sesquiterpene.
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Metadaten
Titel
Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa
verfasst von
Ken-ichi Nakashima
Junko Tomida
Takao Hirai
Yoshiaki Kawamura
Makoto Inoue
Publikationsdatum
19.02.2019
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 3/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-019-01286-8

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