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Journal of Natural Medicines
Erschienen in:

15.10.2024 | Original Paper

Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation

verfasst von: Mitsuhiro Sekiguchi, Mafumi Horiuchi, Yuta Tozawa, Hideyuki Shigemori

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for treating and preventing Alzheimer’s disease. In our search for Aβ42 aggregation inhibitors, we isolated seven undescribed meroterpenoids, sargasilides A (1)‒G (7), from brown alga (Sargassum siliquastrum) collected at Noto Peninsula in Japan. We structurally elucidated the isolated meroterpenoids using spectroscopic data and evaluated their activities using Thioflavin T assay and transmission electron microscopy. Among the seven compounds isolated, sargasilide B had the strongest inhibitory activity. From the comparison of structure and activity, the geometric isomerism of olefins and length of isoprene side chains are important for the activity of meroterpenoids isolated from brown alga.

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Metadaten
Titel
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
verfasst von
Mitsuhiro Sekiguchi
Mafumi Horiuchi
Yuta Tozawa
Hideyuki Shigemori
Publikationsdatum
15.10.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01847-6

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