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31.10.2019 | Case Report

Severe fever with thrombocytopenia syndrome (SFTS) treated with a novel antiviral medication, favipiravir (T-705)

verfasst von: Rui Song, Zhihai Chen, Wei Li

Erschienen in: Infection | Ausgabe 2/2020

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Abstract

Background

Severe fever and thrombocytopenia syndrome (SFTS) is an acute illness with a high mortality (16.2–29.1%). Unfortunately, there is no specific cure or vaccine for SFTS.

Methods

In this open-label study, two patients with SFTS were treated with favipiravir, a new antiviral drug.

Results

Patients had a sustainable virologic, immunologic and symptomatic recovery.

Conclusions

Favipiravir may be a prosiming drug for the treatment of SFTS.

Nur mit Berechtigung zugänglich

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Zhan J, et al. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin. 2017;32:51–62. https://doi.org/10.1007/s12250-016-3931-1.CrossRefPubMedPubMedCentral

Mourya DT, et al. Malsoor virus, a novel bat phlebovirus, is closely related to severe fever with thrombocytopenia syndrome virus and heartland virus. J Virol. 2014;88:3605–9. https://doi.org/10.1128/jvi.02617-13.CrossRefPubMedPubMedCentral

Wang J, et al. Novel phlebovirus with zoonotic potential isolated from ticks, Australia. Emerg Infect Dis. 2014;20:1040–3. https://doi.org/10.3201/eid2006.140003.CrossRefPubMedPubMedCentral

Li H, et al. Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011–17: a prospective observational study. Lancet Infect Dis. 2018;18:1127–37. https://doi.org/10.1016/s1473-3099(18)30293-7.CrossRefPubMed

Yu XJ, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523–32. https://doi.org/10.1056/NEJMoa1010095.CrossRefPubMedPubMedCentral

Baranovich T, et al. T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro. J Virol. 2013;87:3741–51. https://doi.org/10.1128/jvi.02346-12.CrossRefPubMedPubMedCentral

Furuta Y, et al. (T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009;82:95–102. https://doi.org/10.1016/j.antiviral.2009.02.198.CrossRefPubMedPubMedCentral

Gowen BB, et al. Modeling severe fever with thrombocytopenia syndrome virus infection in golden syrian hamsters: importance of STAT2 in preventing disease and effective treatment with favipiravir. J Virol. 2017. https://doi.org/10.1128/jvi.01942-16.CrossRefPubMedPubMedCentral

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Hawman DW, et al. Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice. Antiviral Res. 2018;157:18–26. https://doi.org/10.1016/j.antiviral.2018.06.013.CrossRefPubMed

Titel: Severe fever with thrombocytopenia syndrome (SFTS) treated with a novel antiviral medication, favipiravir (T-705)
verfasst von: Rui Song
Zhihai Chen
Wei Li
Publikationsdatum: 31.10.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 2/2020
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-019-01364-9

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Abstract

Background

Methods

Results

Conclusions

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