Sex Differences in Adiposity, Body Fat Mobilization and Cardiometabolic Health Following Bariatric Surgery
- 23.09.2025
- Research
Erschienen in:
- Verfasst von
- Lajeunesse-Trempe Fannie
- Laurie Marchand
- Maëlle Blais
- Audrey Auclair
- Simon Marceau
- Samuel Alarie
- Paul Poirier
- Marie-Ève Piché
- Erschienen in
- Obesity Surgery | Ausgabe 10/2025
Abstract
Background
Weight loss in light of various weight management strategies, including bariatric surgery, is recognized to vary according to sex.
Objectives
This study aimed to compare sex differences in adiposity phenotypes, body fat mobilization, and obesity-associated comorbidities at baseline and after bariatric surgery.
Methods
Ninety patients (26 men and 64 women) who underwent biliopancreatic diversion with duodenal switch surgery (BPD-DS) were included. Medical history, anthropometric, and bioelectrical impedance measurements as well as computed tomography scans (CT scan) were performed at baseline and at 12-month after BPD-DS. Sex differences in post-operative fat and muscle mobilization were assessed using one-way analysis of variance.
Results
At baseline, men (mean age 44.5 ± 13.2 years) presented a higher global lean mass, abdominal muscle (estimated using CT scan), a higher volume of abdominal visceral fat, and a larger proportion of mid-thigh muscle infiltrated with lipids; a proxy for ectopic fat deposition in skeletal muscle compared to women (p < 0.05 for all). After BPD-DS, there were no differences in fat distribution between sexes, except for abdominal fat volume and muscle infiltrated with lipids which remained higher in men (p < 0.05). These differences translated into a numerically non-significant lower rate of remission of comorbidities in men.
Conclusions
Our result reports on sex differences in body fat mobilization at 12 months post-BPD-DS. Despite comparable body mass index and overall lean and fat mass, men exhibit a higher volume of abdominal fat volume and greater ectopic fat deposition in skeletal muscles compared to women.
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- Titel
- Sex Differences in Adiposity, Body Fat Mobilization and Cardiometabolic Health Following Bariatric Surgery
- Verfasst von
-
Lajeunesse-Trempe Fannie
Laurie Marchand
Maëlle Blais
Audrey Auclair
Simon Marceau
Samuel Alarie
Paul Poirier
Marie-Ève Piché
- Publikationsdatum
- 23.09.2025
- Verlag
- Springer US
- Erschienen in
-
Obesity Surgery / Ausgabe 10/2025
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428 - DOI
- https://doi.org/10.1007/s11695-025-08138-3
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