Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)
- 08.07.2021
- Original Article
Erschienen in:
- Verfasst von
- J. Talevski
- K.M. Sanders
- J.J. Watts
- G.C. Nicholson
- E. Seeman
- S. Iuliano
- R. Prince
- L. March
- T. Winzenberg
- G. Duque
- P.R. Ebeling
- F. Borgström
- J.A. Kanis
- A.L. Stuart
- A. Beauchamp
- S.L. Brennan-Olsen
- Erschienen in
- Osteoporosis International | Ausgabe 1/2022
Abstract
Summary
In this study of 695 Australian older adults (aged ≥50 years), we found that men and women had a similar trajectory of health-related quality of life (HRQoL) recovery following fragility fracture at any skeletal site. These results provide us with critical knowledge that improves our understanding of health outcomes post-fracture.
Introduction
Mortality is higher in men than that in women following a fragility fracture, but it is unclear whether recovery of patient-reported outcomes such as health-related quality of life (HRQoL) differs between sexes. This study aimed to identify sex differences in HRQoL recovery 12 months post-fracture.
Methods
Data were from the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Participants recruited to AusICUROS were adults aged ≥50 years who sustained a fragility fracture. HRQoL was measured using the EQ-5D-3L at three time-points post-fracture: within 2 weeks (including pre-fracture recall) and at 4 and 12 months. Multivariate logistic regression analyses were undertaken, adjusting for confounders including age, education, income, and healthcare utilization post-fracture.
Results
Overall, 695 AusICUROS participants (536 women, 77.1%) were eligible for analysis with fractures at the hip (n = 150), distal forearm (n = 261), vertebrae (n = 61), humerus (n = 52), and other skeletal sites (n = 171). At the time of fracture, men were younger, reported a higher income, and were more likely to be employed, compared with women. For all fracture sites combined, there were no differences between men and women in recovery to pre-fracture HRQoL at 12-month follow-up (adjusted OR = 1.09; 95% CI: 0.75–1.61). When stratified by fracture site, no significant sex differences were seen for hip (OR = 1.02; 95% CI: 0.42–2.52), distal forearm (OR = 1.60; 95% CI: 0.68–3.78), vertebral (OR = 2.28; 95% CI: 0.61–8.48), humeral (OR = 1.62; 95% CI: 0.16–9.99), and other fractures (OR = 1.00; 95% CI: 0.44–2.26).
Conclusion
Community-dwelling men and women who survived the 12 months following fragility fracture had a similar trajectory of HRQoL recovery at any skeletal site.
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- Titel
- Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)
- Verfasst von
-
J. Talevski
K.M. Sanders
J.J. Watts
G.C. Nicholson
E. Seeman
S. Iuliano
R. Prince
L. March
T. Winzenberg
G. Duque
P.R. Ebeling
F. Borgström
J.A. Kanis
A.L. Stuart
A. Beauchamp
S.L. Brennan-Olsen
- Publikationsdatum
- 08.07.2021
- Verlag
- Springer London
- Erschienen in
-
Osteoporosis International / Ausgabe 1/2022
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965 - DOI
- https://doi.org/10.1007/s00198-021-06058-3
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