Background
Methods
Cells and viruses
Animal studies
Study | Experiment | Groups | Number of animals (male Sprague Dawley rats unless otherwise indicated) |
---|---|---|---|
Study #1 | Thermal and mechanical hypersensitivity assay (Figure 3). Neurite retraction study using PGP 9.5 (n = 3/group randomly selected, Figure 2). | Mewo (control) Poka (VZV) |
n = 10
n = 10 |
Study #2 | Place escape/avoidance paradigm (Figure 4). VZV infection detected with IE62 marker (Figure 1). | PBS (vehicle) Mewo (control) Poka (VZV virus) |
n = 6
n = 6
n = 6 |
Study #3 | Gabapentin assay (Figure 5). | Mewo/vehicle Mewo/gabapentin Poka/vehicle Poka/gabapentin |
n = 5
n = 5
n = 5
n = 5 |
Study #4 | Sex differences study comparing males and females (Figure 6). | Mewo/female Mewo/male Poka/female Poka/male |
n = 24
n = 7–15
n = 25
n = 7–15 |
Study #5 | OVX females as compared to males (Sprague Dawley and Long Evans, Figure 7). VZV infection detected with IE62 marker (Sprague-Dawley rats, no figure). | Mewo/male Mewo/female Mewo/OVX female Poka/male Poka/female Poka/OVX female |
n = 5
n = 4
n = 4
n = 7
n = 6
n = 6
n = 5 (Long Evans) for all treatment groups |
Study #6 | Female estrous cycle study (Figure 8). | Mewo diestrus Mewo proestrus/estrus Poka diestrus Poka proestrus/estrus |
n ≥ 8
n ≥ 8
n ≥ 8
n ≥ 8 |