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08.12.2023 | Original Article

Sex-specific grey matter abnormalities in individuals with chronic insomnia

verfasst von: Jingwen Li, Xinzhi Wang, Mengchen Liu, Yi Yin, Yunfan Wu, Guang Xu, Xiaofen Ma

Erschienen in: Neurological Sciences | Ausgabe 5/2024

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Abstract

Previous studies have reported sex differences in altered brain function in patients with chronic insomnia (CI). However, sex-related alterations in brain morphology have rarely been investigated. This study aimed to investigate sex-specific grey matter (GM) alterations in patients with CI and to examine the relationship between GM alterations and neuropsychological assessments. Ninety-three (65 females and 28 males) patients and 78 healthy (50 females and 28 males) controls were recruited. Structural magnetic resonance imaging data were analysed using voxel-based morphometry to test for interactions between sex and diagnosis. Spearman’s correlation was used to assess the associations among structure, disease duration, and sleep-, mood-, and cognition-related assessments. Males with CI showed reduced GM volume in the left inferior parietal lobe, left middle cingulate cortex, and right supramarginal gyrus. Females with CI showed increased GM volume in the right Rolandic operculum. Moreover, mood-related assessments were negatively correlated with GM volumes in the right supramarginal gyrus and left inferior parietal lobe in the male patients, and cognitive-related assessments were positively correlated with GM volumes in the Rolandic operculum in the female patients. Our findings indicate sex-specific alterations in brain morphology in CI, thereby broadening our understanding of sex differences in CI and potentially providing complementary evidence for the development of more effective therapies and individual treatments.

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Titel: Sex-specific grey matter abnormalities in individuals with chronic insomnia
verfasst von: Jingwen Li
Xinzhi Wang
Mengchen Liu
Yi Yin
Yunfan Wu
Guang Xu
Xiaofen Ma
Publikationsdatum: 08.12.2023
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 5/2024
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07224-7

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Sex-specific grey matter abnormalities in individuals with chronic insomnia

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