Background
Methods
Study subjects
Study design
Assessments
Statistics
Results
Study recruitment and population characteristics
Control
n = 30 |
Rehabilitation
n = 30 |
p- Value
| ||
---|---|---|---|---|
Age (years) | 64 (8) | 64 (13) | 0.81 | |
Gender (men) | 15 (50%) | 22 (73%) | 0.06 | |
BMI (Kg/m2) | 26 (5) | 28 (4) | 0.21 | |
Diagnosis | ||||
IIP | 10 (33%) | 11 (37%) | 0.79 | |
• IPF | 7 (23%) | 7 (23%) | 1.0 | |
• NSIP | 3 (10%) | 3 (10%) | 1.0 | |
• DIP | 0 | 1 (3%) | 0.50 | |
KNOWN CAUSES | 12 (40%) | 16 (53%) | 0.30 | |
• Chronic HP | 4 (13%) | 12 (40%) |
0.02
| |
• Asbestosis | 0 | 1 (3%) | 0.50 | |
• Drug induced ILD | 1 (3%) | 1 (3%) | 1.0 | |
• CTD-ILD | 7 (23%) | 2 (7%) | 0.14 | |
UNCLASSIFIABLE ILD | 8 (27%) | 3 (10%) | 0.09 | |
Steroids | 14 (47%) | 15 (50%) | 0.80 | |
SVC | (L) | 2.6 (1.1) | 2.9 (0.7) | 0.35 |
(%pred) | 77 (22) | 76 (20) | 0.86 | |
DLCO | (mmol.min−1.kPa− 1) | 3,4 (1,1) | 4 (1,6) | 0.11 |
(%pred) | 41 (13) | 45 (16) | 0.30 | |
PaO2 (mmHg) | 77 (14) | 76 (11) | 0.71 | |
6MWD | (m) | 491 (95) | 462 (123) | 0.32 |
(%pred) | 79 (14) | 71 (16) |
0.045
| |
Wmax (%pred) | 71 (26) | 61 (20) | 0.10 | |
QF (%pred) | 81 (36) | 78 (23) | 0.70 | |
HF (%pred) | 85 (27) | 89 (23) | 0.61 | |
SGRQ total (points) | 40 (18) | 42 (14) | 0.68 | |
Physical Activity (PA) | ||||
• Steps per day | 7182 (3523) | 5745 (3312) | 0.12 | |
• MPA | 57 (21–158) | 36 (10–130) | 0.14 |
Effects
Control
|
Rehabilitation
|
Rehabilitation
effect mean (95% CI ll,ul)
|
p- Value
| |
---|---|---|---|---|
6MWD (m) | ||||
Baseline | 491 (57) | 462 (57) | 0.36 | |
3 months | 474 (57) | 504 (57) | 59 (33, 85) |
< 0.001
|
6 months | 468 (57) | 511 (57) | 72 (36, 108) |
< 0.001
|
1 year | 456 (57) | 501 (57) | 73 (28, 118) |
0.002
|
Wmax (%pred) | ||||
Baseline | 71 (18) | 61 (18) | 0.15 | |
3 months | 68 (18) | 68 (18) | 10 (2, 19) |
0.01
|
6 months | 62 (18) | 71 (18) | 19 (8, 29) |
< 0.001
|
1 year | 61 (18) | 74 (18) | 23 (10, 35) |
< 0.001
|
SVC (%pred) | ||||
Baseline | 77 (21) | 76 (21) | 0.86 | |
3 months | 77 (21) | 78 (21) | 2 (−2, 6) | 0.23 |
6 months | 75 (21) | 77 (21) | 3 (−1, 7) | 0.20 |
1 year | 76 (21) | 79 (21) | 4 (−0.2, 9) | 0.06 |
DLCO (%pred) | ||||
Baseline | 42 (13) | 45 (13) | 0.31 | |
3 months | 39 (13) | 44 (13) | 1.2 (− 2.4, 4.8) | 0.52 |
6 months | 39 (13) | 43(13) | 0.9 (−3.6, 5.3) | 0.70 |
1 year | 38 (13) | 45 (13) | 3.2 (−1.8, 8.2) | 0.21 |
QF (%pred) | ||||
Baseline | 81 (27) | 78 (27) | 0.69 | |
3 months | 81 (27) | 88 (27) | 10 (2, 18) |
0.01
|
6 months | 83 (27) | 90 (27) | 10 (1, 18) |
0.02
|
1 year | 88 (27) | 94 (27) | 9.5 (1, 18) |
0.04
|
HF (%pred) | ||||
Baseline | 73 (17) | 76(17) | 0.56 | |
3 months | 76 (17) | 91 (17) | 12.5 (5, 20) |
0.002
|
6 months | 75 (17) | 90 (17) | 12 (4, 20) |
0.004
|
1 year | 79 (17) | 88 (17) | 6 (−3, 15) | 0.20 |
SGRQ total | ||||
Baseline | 40 (14) | 42 (14) | 0.68 | |
3 months | 44 (14) | 39 (14) | −7 (−13, −2) |
0.005
|
6 months | 46 (14) | 35 (14) | −12 (−19, −6) |
< 0.001
|
1 year | 45 (14) | 35 (14) | −11 (− 18, −4) |
0.002
|
Control
|
Rehabilitation
|
Rehabilitation
effect mean (95% CI ll,ul)
|
p- Value
| |
---|---|---|---|---|
Steps | ||||
Baseline | 7013 (2598) | 5671 (2598) | 0.10 | |
3 months | 6593 (2598) | 5721 (2598) | 470 (− 920, 1860) | 0.50 |
6 months | 6118 (2598) | 5540 (2598) | 764 (− 746, 2274) | 0.32 |
MPA | ||||
Baseline | 54 (38, 78) | 36 (25, 52) | 0.46 | |
3 months | 44 (31, 64) | 37 (26, 54) | 1.3 (0.7, 2.2) | 0.42 |
6 months | 41 (29, 60) | 33 (23, 48) | 1.2 (0.6, 2.3) | 0.57 |