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Erschienen in: Clinical and Experimental Nephrology 1/2018

01.02.2018 | Original article

Short- and long-term outcomes after non-severe acute kidney injury

verfasst von: Carlos Arias-Cabrales, Eva Rodríguez, Sheila Bermejo, Adriana Sierra, Carla Burballa, Clara Barrios, María José Soler, Julio Pascual

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 1/2018

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Abstract

Background

Severe acute kidney injury (AKI) is associated with chronic kidney disease (CKD), cardiovascular events and increased mortality. However, little is known about the prognosis in hospitalized population suffering from non-severe AKI episodes. The aim of this study is to determine the impact of non-severe AKI episodes in cardiovascular events, mortality and CKD, on short and long term.

Methods

Retrospective cohort study to 360 patients who met the criteria for diagnosis of AKI according ADQI guidelines with full recovery of renal function after the AKI episode, admitted between January 2000 and December 2010 in our hospital. Follow-up was 4 years after the diagnosis of AKI. Covariates included demographic variables, baseline creatinine and diagnosis of comorbidities.

Results

360 AKI survivor patients were included. Twenty five of them (6.7%) had developed CKD after 1-year follow-up. Hypertension (OR 1.62; 95% CI 1.2–2.6, p < 0.05) and serum creatinine >2.6 mg/dL in AKI (OR 1.7; 95% CI 1.2–3.7, p < 0.05) were independent risk factors. After 4-year follow-up, 40 patients (18.3%) had developed CKD; age >66 years was an independent risk factor (OR 1.03, 95% CI 1.03–1.06, p < 0.05). Mortality rate at 4 years was 25.3% and was significantly higher in CKD patients (OR 4.3, 95% CI 1.13–4.90, p < 0.05) and patients >66 years (OR 1.12, 95% CI 1.02–1.06, p < 0.05). The incidence of cardiovascular events also was higher in CKD patients than in non-CKD patients (62.7 vs. 21.7%, p < 0.05).

Conclusion

Even after fully recovered non-severe AKI episodes, some patients develop CKD and those have an increase in the incidence of cardiovascular events and long-term mortality.
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Metadaten
Titel
Short- and long-term outcomes after non-severe acute kidney injury
verfasst von
Carlos Arias-Cabrales
Eva Rodríguez
Sheila Bermejo
Adriana Sierra
Carla Burballa
Clara Barrios
María José Soler
Julio Pascual
Publikationsdatum
01.02.2018
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 1/2018
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-017-1420-y

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