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09.08.2018 | Original Article

Short-term association between outdoor air pollution and osteoporotic hip fracture

verfasst von: R. Mazzucchelli, N. Crespi Villarias, E. Perez Fernandez, M. L. Durban Reguera, A. Garcia-Vadillo, F. J. Quiros, O. Guzon, G. Rodriguez Caravaca, A. Gil de Miguel

Erschienen in: Osteoporosis International | Ausgabe 10/2018

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Abstract

Summary

This study examines the association of the levels of different airborne pollutants on the incidence of osteoporotic hip fracture in a southern European region. Association was detected between SO₂ and NO₂ and hospital admissions due to hip fracture.

Introduction

To examine the short-term effects of outdoor air pollution on the incidence of osteoporotic hip fracture in a southern European region.

Methods

This is an ecological retrospective cohort study based on data obtained from three databases. In a time-series analysis, we examined the association between hip fracture incidence and different outdoor air pollutants (sulfur dioxide (SO₂), monoxide (NO), nitrogen dioxide (NO₂), ozone (O₃), and particulate matter in suspension < 2.5 (PM_2.5) and < 10-μm (PM₁₀) conditions by using general additive models (Poisson distribution). The incidence rate ratio (IRR), crude and adjusted by season and different weather conditions, was estimated for all parameters. Hip incidence was later analyzed by sex and age (under or over age 75) subgroups. The main outcome measure was daily hospital admissions due to fracture.

Results

Hip fracture incidence showed association with SO₂ (IRR 1.11 (95% CI 1.04–1.18)), NO (IRR 1.01 (95% CI 1.01–1.02)), and NO₂ (IRR 1.02 (95% CI 1.01–1.04)). For O₃ levels, this association was negative (IRR 0.97 (95% CI 0.95–0.99)). The association persisted for SO₂ and NO₂ when the models were adjusted by season. After adjusting by season and weather conditions, the association persisted for NO₂. When participants were stratified by age and sex, associations persisted only in women older than 75 years.

Conclusions

A short-term association was observed with several indicators of air pollution on hip fracture incidence. This is the first study that shows these associations.

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Titel: Short-term association between outdoor air pollution and osteoporotic hip fracture
verfasst von: R. Mazzucchelli
N. Crespi Villarias
E. Perez Fernandez
M. L. Durban Reguera
A. Garcia-Vadillo
F. J. Quiros
O. Guzon
G. Rodriguez Caravaca
A. Gil de Miguel
Publikationsdatum: 09.08.2018
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 10/2018
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4605-7

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Short-term association between outdoor air pollution and osteoporotic hip fracture

Abstract

Summary

Introduction

Methods

Results

Conclusions

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Springer Medizin

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Summary

Introduction

Methods

Results

Conclusions

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