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Archives of Gynecology and Obstetrics

Erschienen in:

01.03.2009 | Original Article

Short-term effect of tibolone on C-reactive protein in hypertensive postmenopausal women

verfasst von: Yaprak Engin-Üstün, Yusuf Üstün, Ilgın Türkçüoğlu, M. Mutlu Meydanlı, Ayşe Kafkaslı, Gülay Yetkin

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2009

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Abstract

Objective

To evaluate the effects of tibolone on the serum C-reactive protein (CRP) in hypertensive postmenopausal women.

Methods

We enrolled 45 postmenopausal patients with hypertension and 17 normotensive postmenopausal women. Inclusion criteria were surgical menopause, the presence of vasomotor symptoms, and normal mammogram within 1 year, the absence of documented coronary artery disease, and normal electrocardiography. Forty hypertensive women and 17 normotensive women completed the 3-month period. Twenty-one hypertensive women received tibolone, whereas 19 served as control. At baseline and at 3 months, blood lipids and CRP were evaluated.

Results

Changes in lipid profile and CRP in the hypertensive and normotensive control groups during 3 months were not statistically significant. Total cholesterol levels decreased significantly after 3 months of tibolone treatment. A significant increase in CRP values was observed in the tibolone group (p = 0.001).

Conclusion

This trial demonstrated that tibolone treatment induced a significant increase in CRP and a significant decrease in total cholesterol in postmenopausal hypertensive women.

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Titel: Short-term effect of tibolone on C-reactive protein in hypertensive postmenopausal women
verfasst von: Yaprak Engin-Üstün
Yusuf Üstün
Ilgın Türkçüoğlu
M. Mutlu Meydanlı
Ayşe Kafkaslı
Gülay Yetkin
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2009
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0712-6

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Short-term effect of tibolone on C-reactive protein in hypertensive postmenopausal women

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