The purpose of this study is to evaluate short-term effects and safety of an acute increase of intraocular pressure (IOP) after single-dose intravitreal bevacizumab injection on corneal endothelial cells and central corneal thickness.
Forty-two patients who underwent intravitreal injection of 2.5 mg/0.1 ml bevacizumab because of central serous chorioretinopathy or diabetic macular edema were included in this study. The changes of IOP, corneal endothelial cells, and corneal thickness at baseline, 2 min, 5 min, and 30 min after injection were analyzed prospectively with a specular microscope.
In all patients, the mean IOPs at baseline, 2 min, 5 min, and 30 min after injection were 11.48 ± 2.22 mmHg, 49.71 ± 10.73 mmHg, 37.64 ± 11.68 mmHg, and 14.88 ± 4.77 mmHg, respectively. These changes were significant (p < 0.01). In only one eye, IOP did not decrease to ≤30 mmHg even at 30 min after injection. According to changes in IOP with time, the coefficient of variation of the corneal endothelium significantly increased (p = 0.03), but cell density, hexagonality of the corneal endothelium, and central corneal thickness did not change (p = 0.79, 0.21, and 0.08, prospectively). One week after injection, there was no sign of inflammation or any other complications in all 42 eyes.
After intravitreal injection, IOP rapidly increases, then decreases to the normal range in most eyes 30 min after injection and it is tolerable to corneal endothelium.
Clinical Research Information Service (CRiS), Republic of Korea, KCT0002645. Retrospectively registered 9 January 2018.
Frischbarg J, Hernandez J, Liebowitch LS, Koniarek JP. The mechanism of fluid and electrolyte transport across corneal endothelium. Curr Eye Res. 1985;4:351–60. CrossRef
Nishida T, Saika S. Cornea and Sclera: anatomy and physiology. In: Krachmer JH, Mannis MJ, Holland EJ, editors. Cornea. 3rd ed. St. Louis: MO Mosby; 2011. p. 15–6.
Jorge J, Queiros A, Peixoto-de-Matos SC, Ferrer-Blasco T, González-Méijome JM. Age-related changes of corneal endothelium in normal eyes with a non-contact specular microscope. Journal of Emmetropia. 2010;1(2):132–9.
Koo GH, Jea SY, Lee JS, Oum BS. Differences in intraocular pressure, corneal thickness, and corneal endothelium related to duration in diabetes. J Korean Ophthalmol. 2004;45(8):1250–5.
Oh TH, Chang DJ, Ki JW, Moon JI, Kim SK. The importance of evaluation of corneal endothelial cell count in glaucoma patients. J Korean Ophthalmol Soc. 2012;53(1):37–42. CrossRef
Miller D, Weiss JN. The effect of corneal stretch on the endothelium. Ophthalmic Surg. 1981;12(10):731–6. PubMed
Setala K. Response of human corneal endothelial cells to increased intraocular pressure. Acta Ophthalmol Suppl. 1980;144:1–38.
- Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells
- BioMed Central
Neu im Fachgebiet Augenheilkunde