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01.06.2015 | Ausgabe 6/2015

Surgical Endoscopy 6/2015

Should prophylactic cholecystectomy be performed in patients with concomitant gallstones after endoscopic sphincterotomy for bile duct stones?

Zeitschrift:
Surgical Endoscopy > Ausgabe 6/2015
Autoren:
Jun Heo, Min Kyu Jung, Chang Min Cho
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00464-014-3844-8) contains supplementary material, which is available to authorized users.

Abstract

Background

Endoscopic sphincterotomy (EST) is the standard treatment for biliary duct stones. However, performing additional cholecystectomy after EST is controversial. In this study, we aimed to evaluate the effects of cholecystectomy after EST.

Methods

Between December 2008 and July 2011, we performed a prospective, randomized, single-center trial in 90 patients with proven gallstones who underwent EST and stone extraction. After the procedure, patients were randomly allocated to undergo cholecystectomy (n = 45) or to the group of GB left in situ (n = 45). The primary outcome was biliary complications at follow-up.

Results

Cholecystectomy was performed in 26 patients (60.5 %) in cholecystectomy group and in 13 patients (28.9 %) in intended conservative group. The median follow-up was 41 months. An intention-to-treat analysis showed that 8 patients (18.6 %) in the cholecystectomy group and 9 (20.0 %) in those who had their GB left in situ had recurrent biliary events (Kaplan–Meier curve, Breslow test, p = 0.555). In an as-treated analysis, 4 patients (10.3 %) who underwent cholecystectomy and 13 patients (26.5 %) who did not undergo cholecystectomy had additional biliary events during the follow-up period (Log-rank, p = 0.037). However, additional biliary events of cholangitis were similar in the two groups, except for a case of cholecystitis (Log-rank, p = 0.998).

Conclusions

Cholecystectomy after EST for biliary duct stones fails to reduce additional recurrent cholangitis but reduces additional cholecystitis.

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Zusatzmaterial
Fig. S1 Intention-to-treat analysis showing cumulative recurrence of biliary-related events (TIFF 40 kb)
464_2014_3844_MOESM1_ESM.tif
Fig. S2 Per-protocol analysis showing cumulative recurrence of biliary-related events (TIFF 60 kb)
464_2014_3844_MOESM2_ESM.tif
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