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11.08.2023 | Original Article

Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis

verfasst von: Ana Carolina C. Barbosa, Raquel S. Brison, Carolina C. Gomes, Thomas J. Wilkinson, Marvery P. Duarte, Nádia Dias Gruezo, Heitor S. Ribeiro

Erschienen in: Pediatric Nephrology | Ausgabe 2/2024

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Abstract

Background

Pediatric patients with chronic kidney disease (CKD) frequently present an inadequate nutritional profile and musculoskeletal impairments. We investigated sarcopenia and its related traits in children and adolescents with CKD.

Methods

A cross-sectional study that enrolled pediatric patients with CKD (≥ 4 and < 18 years old). Physical function was assessed by handgrip strength and the 60-s sit-to-stand (STS-60) tests. Body composition measurement was performed by bioelectrical impedance analysis and anthropometry through mid-upper arm circumference (MUAC). Normative reference values from healthy pediatrics were used for identifying poor physical function and low MUAC. Probable sarcopenia was considered as low handgrip strength, whereas sarcopenia was defined by adding low MUAC.

Results

Twenty-two pediatric patients with CKD (11 ± 4 years and 59% boys) were evaluated; eight on peritoneal dialysis (36%), six on hemodialysis (27%), and eight non-dialysis (36%). Regarding sarcopenia traits, we observed low physical function by handgrip strength and STS-60 in 59% and 100% of the patients, respectively, while low MUAC in 77%. Probable sarcopenia was found in 9% and sarcopenia in 50%, but prevalence did not differ among stages. Handgrip strength was strongly associated with MUAC (r = 0.90; p < 0.001); on the other hand, the STS-60 was not significantly associated with any of the body composition variables.

Conclusion

Among pediatric patients with CKD, the prevalence of sarcopenia and its related traits was high. Nephrology professionals should consider the assessment of sarcopenia in this population, while more evidence is needed to determine its prognostic value.

Graphical Abstract

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Titel: Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis
verfasst von: Ana Carolina C. Barbosa
Raquel S. Brison
Carolina C. Gomes
Thomas J. Wilkinson
Marvery P. Duarte
Nádia Dias Gruezo
Heitor S. Ribeiro
Publikationsdatum: 11.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 2/2024
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06111-9

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Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis