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Immunologic Research

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01.08.2017 | Interpretive Synthesis Review Article

Signaling interactions predicted by the Tritope model of the TCR

verfasst von: Melvin Cohn

Erschienen in: Immunologic Research | Ausgabe 5/2017

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Abstract

As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified.

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Titel: Signaling interactions predicted by the Tritope model of the TCR
verfasst von: Melvin Cohn
Publikationsdatum: 01.08.2017
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 5/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-017-8941-z

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