Individual biomarkers, especially those of kidney injury, have been associated with poor outcomes and mortality among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [
1‐
3]. Male sex is also a definitive risk factor for death [
1] which may be due, in part, to sex differences in biological pathways including kidney injury [
2]. Externally-validated risk strata based on a large number of biomarkers have not been described and could have implications for clinical management of SARS-CoV-2-infected patients. Our primary aim was to identify and replicate signature time-varying biomarker states, integrating kidney and other pathophysiologies, that associate with 28-day-mortality among hospitalized SARS-CoV-2-infected patients. …