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Inflammation

Erschienen in:

01.06.2014

Significant Roles Played by IL-10 in Chlamydia Infections

verfasst von: Hamid Hakimi, Mohammad Zare-Bidaki, Nahid Zainodini, Shokrollah Assar, Mohammad Kazemi Arababadi

Erschienen in: Inflammation | Ausgabe 3/2014

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Abstract

Chlamydia species are obligate intracellular parasites which cause usually asymptomatic genital tract infections and also are associated with several complications. Previous studies demonstrated that immune responses to Chlamydia species are different and the diseases will be limited to some cases. Additionally, Chlamydia species are able to modulate immune responses via regulating expression of some immune system molecules including cytokines. IL-10, as the main anti-inflammatory cytokine, plays important roles in the induction of immune-tolerance against self-antigen and also immune-homeostasis after microbe elimination. Furthermore, it has been documented that ectopic expression of IL-10 is associated with several chronic infectious diseases. Therefore, it can be hypothesized that changes in the regulation of this cytokine can be associated with infection with several species of Chlamydia and their associated complications. This review collected the recent information regarding the association and relationship of IL-10 with Chlamydia infections. Another aim of this review article is to address recent data regarding the association of genetic variations (polymorphisms) of IL-10 and Chlamydia infections.

Hakimi H, Zainodini N, Khorramdelazad H, et al. 2013. Seminal levels of pro inflammatory (CXCL1, CXCL9, CXCL10) and homeostatic (CXCL12) chemokines in men suffering from asymptomatic Chlamydial trachomatis infection. Jundishapur Journal of Microbiology.

Choroszy-Król, I., M. Frej-Mądrzak, A. Jama-Kmiecik, et al. 2012. Characteristics of the Chlamydia trachomatis species—immunopathology and infections. Advances in clinical and Experimental Medicine: Official Organ Wroclaw Medical University 21: 799.

Hakimi H, Akhondi MM, Sadeghi MR, et al. 2013. Seminal Levels of IL-10, IL-12, and IL-17 in Men with Asymptomatic Chlamydia Infection. Inflammation.

Batteiger, B.E., F. Xu, R.E. Johnson, et al. 2010. Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies. Journal of Infectious Diseases 201: S178–S189.PubMedCentralPubMedCrossRef

Arababadi, M.K., B. Nasiri Ahmadabadi, and D. Kennedy. 2012. Current information on the immunologic status of occult hepatitis B infection. Transfusion 52: 1819–1826.PubMedCrossRef

Li, Y.P., V. Latger-Canard, L. Marchal, et al. 2006. The regulatory role of dendritic cells in the immune tolerance. Biomedical Materials and Engineering 16: S163–S170.PubMed

Karimabad, M.N., M.K. Arababadi, E. Hakimizadeh, et al. 2013. Is the IL-10 promoter polymorphism at position -592 associated with immune system-related diseases? Inflammation 36: 35–41.PubMedCrossRef

Arababadi, M.K., R. Mosavi, H. Khorramdelazad, et al. 2010. Cytokine patterns after therapy with Avonex®, Rebif®, Betaferon® and CinnoVex in relapsing-remitting multiple sclerosis in Iranian patients. Biomarkers in Medicine 4: 755–759.PubMedCrossRef

Arababadi, M.K., A.A. Pourfathollah, A.A. Jafarzadeh, et al. 2010. Serum levels of Interleukin (IL)-10 and IL-17A in occult HBV infected south-east Iranian patients. Hepatitis Monthly 10: 31–35.PubMedCentralPubMed

10.

del Rio, L., M. Barbera-Cremades, J.A. Navarro, et al. 2013. IFN-γ expression in placenta is associated to resistance to Chlamydia abortus after intragastric infection. Microbial Pathogenesis 56: 1–7.PubMedCrossRef

11.

Karjalainen, J., J. Hulkkonen, M.M. Nieminen, et al. 2003. Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma. Clinical and Experimental Allergy 33: 78–83.PubMedCrossRef

12.

Groux, H., and F. Cottrez. 2003. The complex role of interleukin-10 in autoimmunity. Journal of Autoimmunity 20: 281–285.PubMedCrossRef

13.

Howell, W.M., and M.J. Rose-Zerilli. 2006. Interleukin-10 polymorphisms, cancer susceptibility and prognosis. Familial Cancer 5: 143–149.PubMedCrossRef

14.

Sabat, R., G. Grutz, K. Warszawska, et al. 2010. Biology of interleukin-10. Cytokine and Growth Factor Reviews 21: 331–344.PubMedCrossRef

15.

Shah, N., J. Kammermeier, M. Elawad, et al. 2012. Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease. Current Allergy and Asthma Reports 12: 373–379.PubMedCrossRef

16.

Scapini, P., C. Lamagna, Y. Hu, et al. 2011. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 2011: 12.

17.

Kontoyiannis, D., A. Kotlyarov, E. Carballo, et al. 2001. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. The EMBO Journal 20: 3760–3770.PubMedCentralPubMedCrossRef

18.

Donnelly, R.P., H. Dickensheets, and D.S. Finbloom. 1999. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. Journal of Interferon & Cytokine Research 19: 563–573.CrossRef

19.

Gaba, A., S.I. Grivennikov, M.V. Do, et al. 2012. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. The Journal of Immunology 189: 2089–2093.PubMedCentralPubMedCrossRef

20.

Takagi, H., T. Sanada, Y. Minoda, et al. 2004. Regulation of cytokine and toll-like receptor signaling by SOCS family genes. Nihon Rinsho Japanese Journal of Clinical Medicine 62: 2189.PubMed

21.

Strle, K., J.-H. Zhou, S.R. Broussard, et al. 2002. IL-10 promotes survival of microglia without activating Akt. Journal of Neuroimmunology 122: 9–19.PubMedCrossRef

22.

Bebien, M., M.E. Hensler, S. Davanture, et al. 2012. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathogens 8: e1002812.PubMedCentralPubMedCrossRef

23.

Moore, K.W., M.R. de Waal, R.L. Coffman, et al. 2001. Interleukin-10 and the interleukin-10 receptor. Annual Review of Immunology 19: 683–765.PubMedCrossRef

24.

Booy, R., S. Nadel, M. Hibberd, et al. 1997. Genetic influence on cytokine production in meningococcal disease. Lancet 349: 1176.PubMedCrossRef

25.

Zhang, Y., J. Zhang, C. Tian, et al. 2011. The -1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimer’s disease: a meta-analysis. Journal of the Neurological Sciences 303: 133–138.PubMedCrossRef

26.

Lopez, P., C. Gutierrez, and A. Suarez. 2010. IL-10 and TNFalpha genotypes in SLE. Journal of Biomedicine and Biotechnology 2010: 838390.PubMedCentralPubMedCrossRef

27.

Ward, M. 1983. Chlamydial classification, development and structure. British Medical Bulletin 39: 109–115.PubMed

28.

Niemczuk, K., and M. Truszczyński. 2001. Pathogenicity of the microorganisms of the family Chlamydiaceae respecting the changes in their classification. Polish Journal of Veterinary Sciences 5: 99–101.

29.

Di Francesco A, Favaroni A, Donati M. 2013. Host defense peptides: general overview and an update on their activity against Chlamydia spp. Expert Review Anti Infective Therapy.

30.

Organization WH. 2011. Prevalence and incidence of selected sexually transmitted infections, Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis and Trichomonas vaginalis: methods and results used by WHO to generate 2005 estimates. Geneva: World Health Organization 978:4.

31.

Wilson, J., E. Honey, A. Templeton, et al. 2002. A systematic review of the prevalence of Chlamydia trachomatis among European women. Human Reproduction Update 8: 385–394.PubMedCrossRef

32.

Lanjouw, E., J. Ossewaarde, A. Stary, et al. 2010. 2010 European guideline for the management of Chlamydia trachomatis infections. International Journal of STD & AIDS 21: 729–737.CrossRef

33.

Salmeri, M., A. Santanocita, M.A. Toscano, et al. 2010. Chlamydia trachomatis prevalence in unselected infertile couples. Systems Biology in Reproductive Medicine 56: 450–456.PubMedCrossRef

34.

Cates Jr., W., and J.N. Wasserheit. 1991. Genital chlamydial infections: epidemiology and reproductive sequelae. American Journal of Obstetrics and Gynecology 164: 1771–1781.PubMedCrossRef

35.

Awwad, Z.M., A.A. Al-Amarat, and A.A. Shehabi. 2003. Prevalence of genital chlamydial infection in symptomatic and asymptomatic Jordanian patients. International Journal of Infectious Diseases 7: 206–209.PubMedCrossRef

36.

Fallah F, Kazemi B, Goudarzi H, et al. 2005. Detection of Chlamydia trachomatis from urine specimens by PCR in women with cervicitis. Iranian Journal of Public Health 34.

37.

Abbas, M., L.D. Bobo, Y.-H. Hsieh, et al. 2009. Human leukocyte antigen (HLA)-B, DRB1, and DQB1 allotypes associated with disease and protection of trachoma endemic villagers. Investigative Ophthalmology & Visual Science 50: 1734–1738.CrossRef

38.

Mylonas, I. 2012. Female genital Chlamydia trachomatis infection: where are we heading? Archives of Gynecology and Obstetrics 285: 1271–1285.PubMedCrossRef

39.

Igietseme, J.U., G.A. Ananaba, J. Bolier, et al. 2000. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. The Journal of Immunology 164: 4212–4219.PubMedCrossRef

40.

Campbell, L.A., K. Yaraei, B. Van Lenten, et al. 2010. The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis. Microbes and Infection 12: 598–606.PubMedCentralPubMedCrossRef

41.

Gupta, R., H. Vardhan, P. Srivastava, et al. 2009. Modulation of cytokines and transcription factors (T-Bet and GATA3) in CD4 enriched cervical cells of Chlamydia trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and C. Reproductive Biology and Endocrinology 7: 84.PubMedCentralPubMedCrossRef

42.

Azenabor, A.A., and J. York. 2010. Chlamydia trachomatis evokes a relative anti-inflammatory response in a free Ca2+ dependent manner in human macrophages. Comparative Immunology, Microbiology and Infectious Diseases 33: 513–528.PubMedCrossRef

43.

Ohman, H., A. Tiitinen, M. Halttunen, et al. 2009. Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility. The Journal of Infectious Diseases 199: 1353–1359.PubMedCrossRef

44.

Moniz, R.J., A.M. Chan, and K.A. Kelly. 2009. Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum. FEMS Immunology & Medical Microbiology 55: 226–236.CrossRef

45.

Rizzo, A., R. Paolillo, A.G. Lanza, et al. 2008. Chlamydia pneumoniae induces interleukin‐6 and interleukin‐10 in human gingival fibroblasts. Microbiology and Immunology 52: 447–454.PubMedCrossRef

46.

Agrawal, T., V. Vats, S. Salhan, et al. 2009. Determination of chlamydial load and immune parameters in asymptomatic, symptomatic and infertile women. FEMS Immunology & Medical Microbiology 55: 250–257.CrossRef

47.

Vats, V., T. Agrawal, S. Salhan, et al. 2007. Primary and secondary immune responses of mucosal and peripheral lymphocytes during Chlamydia trachomatis infection. FEMS Immunology & Medical Microbiology 49: 280–287.CrossRef

48.

Han, X., S. Wang, Y. Fan, et al. 2006. Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice. The Journal of Immunology 176: 5232–5239.PubMedCrossRef

49.

Reddy, B., S. Rastogi, B. Das, et al. 2004. Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women—implication for T‐cell responses. Clinical & Experimental Immunology 137: 552–558.CrossRef

50.

Caspar-Bauguil, S., B. Puissant, D. Nazzal, et al. 2000. Chlamydia pneumoniae induces interleukin-10 production that down-regulates major histocompatibility complex class I expression. Journal of Infectious Diseases 182: 1394–1401.PubMedCrossRef

51.

Geng, Y., R.B. Shane, K. Berencsi, et al. 2000. Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10. The Journal of Immunology 164: 5522–5529.PubMedCrossRef

52.

Kotake, S., H.R. Schumacher, T.K. Arayssi, et al. 1999. Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers. Infection and Immunity 67: 2682–2686.PubMedCentralPubMed

53.

Agrawal, T., R. Gupta, R. Dutta, et al. 2009. Protective or pathogenic immune response to genital chlamydial infection in women—a possible role of cytokine secretion profile of cervical mucosal cells. Clinical Immunology 130: 347–354.PubMedCrossRef

54.

Kinnunen, A., H.M. SURCEL, M. Halttunen, et al. 2003. Chlamydia trachomatis heat shock protein‐60 induced interferon‐γ and interleukin‐10 production in infertile women. Clinical & Experimental Immunology 131: 299–303.CrossRef

55.

Kinnunen, A., P. Molander, R. Morrison, et al. 2002. Chlamydial heat shock protein 60-specific T cells in inflamed salpingeal tissue. Fertility and Sterility 77: 162–166.PubMedCrossRef

56.

Öhman, H., A. Tiitinen, M. Halttunen, et al. 2006. IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis. Genes and Immunity 7: 243–249.PubMedCrossRef

57.

Natividad, A., J. Wilson, O. Koch, et al. 2005. Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci. Genes and Immunity 6: 332–340.PubMedCrossRef

58.

Wang, C., J. Tang, W.M. Geisler, et al. 2005. Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents. Journal of Infectious Diseases 191: 1084–1092.PubMedCrossRef

59.

Kinnunen, A.H., H. Surcel, M. Lehtinen, et al. 2002. HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case–control study. Human Reproduction 17: 2073–2078.PubMedCrossRef

60.

Mozzato-Chamay, N., O.S. Mahdi, O. Jallow, et al. 2000. Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis—endemic population. Journal of Infectious Diseases 182: 1545–1548.PubMedCrossRef

61.

Hvid, M., A. Baczynska, B. Deleuran, et al. 2007. Interleukin‐1 is the initiator of fallopian tube destruction during Chlamydia trachomatis infection. Cellular Microbiology 9: 2795–2803.PubMedCrossRef

62.

Penttila, T., A. Haveri, A. Tammiruusu, et al. 2008. Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response. Microbial Pathogenesis 45: 25–29.PubMedCrossRef

Titel: Significant Roles Played by IL-10 in Chlamydia Infections
verfasst von: Hamid Hakimi
Mohammad Zare-Bidaki
Nahid Zainodini
Shokrollah Assar
Mohammad Kazemi Arababadi
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 3/2014
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-013-9801-1

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Significant Roles Played by IL-10 in Chlamydia Infections

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