Skip to main content
Erschienen in:

06.01.2022 | Research article

Sinapic acid restores blood parameters, serum antioxidants, and liver and kidney functions in obesity

verfasst von: Khaled M. M. Koriem, Islam B. Gad

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Obesity is an additional body fat that causes a harmful effect on human health while sinapic acid (SA) is a phyto-constituent presents in spices, citrus, berry fruits, and vegetables. This study evaluates SA to amend blood parameters, serum glucose, proteins, lipids, and antioxidants, and liver and kidney functions in obese rats. Thirty male albino rats were divided into 2 groups (normal and obese rats). The normal, non-obese rats subdivided into 2 subgroups; Control and SA (40 mg/kg) subgroup: daily oral intake of 1 ml saline and 40 mg/kg SA, respectively once a day. The obese rats subdivided also into 3 subgroups; Obese, Obese + SA (20 mg/kg), and Obese + SA (40 mg/kg)-treated groups which received no treatment, 20 mg/kg SA, and 40 mg/kg SA, respectively once a day. All treatments were orally administrated for 1 month. The results showed that obesity caused an increase in body and organ weight, serum total cholesterol, triglycerides, low density lipoproteins, malondialdehyde, nitric oxide, glucose, bilirubin and blood urea nitrogen while decrease serum superoxide dismutase, glutathione peroxidase, glutathione, glutathione reductase, glutathione-S-transferase, hemoglobin, hematocrite, red blood cells, white blood cells, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine, and uric acid compared to control group. Obesity caused disappearance of prothrombin and fibrinogen proteins and damages to liver and kidney tissues. The oral administration with SA daily for 1 month in obese rats returned all these parameters to the control values where the higher dose of SA was more effective than the lower dose. In conclusion, SA restores body and organ weight, blood parameters, serum glucose, proteins, lipids, antioxidants, and liver and kidney functions in obesity.
Literatur
1.
Zurück zum Zitat Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA. 1999;282(16):1530–8.CrossRef Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA. 1999;282(16):1530–8.CrossRef
2.
Zurück zum Zitat Fried M, Hainer V, Basdevant A, Buchwald H, Deitel M, Finer N, Greve JW, Horber F, Mathus-Vliegen E, Scopinaro N, Steffen R, Tsigos C, Weiner R, Widhalm K. Inter-disciplinary European guidelines on surgery of severe obesity. Int J Obes. 2007;31(4):569–77.CrossRef Fried M, Hainer V, Basdevant A, Buchwald H, Deitel M, Finer N, Greve JW, Horber F, Mathus-Vliegen E, Scopinaro N, Steffen R, Tsigos C, Weiner R, Widhalm K. Inter-disciplinary European guidelines on surgery of severe obesity. Int J Obes. 2007;31(4):569–77.CrossRef
3.
Zurück zum Zitat Tsigos C, Hainer V, Basdevant A, Finer N, Fried M, Mathus-Vliegen E, Micic D, Maislos M, Roman G, Schutz Y, Toplak H, Zahorska-Markiewicz B. Management of obesity in adults: European clinical practice guidelines. Obes Facts. 2008;1(2):106–16.CrossRef Tsigos C, Hainer V, Basdevant A, Finer N, Fried M, Mathus-Vliegen E, Micic D, Maislos M, Roman G, Schutz Y, Toplak H, Zahorska-Markiewicz B. Management of obesity in adults: European clinical practice guidelines. Obes Facts. 2008;1(2):106–16.CrossRef
4.
Zurück zum Zitat Tchang BG, Saunders KH, Igel LI. Best practices in the management of overweight and obesity. Med Clin North Am. 2021;105(1):149–74.CrossRef Tchang BG, Saunders KH, Igel LI. Best practices in the management of overweight and obesity. Med Clin North Am. 2021;105(1):149–74.CrossRef
5.
Zurück zum Zitat Ramírez-De Los Santos S, López-Pulido EI, Medrano-González IDC, Becerra-Ruiz JS, Alonso-Sanchez CC, Vázquez-Jiménez SI, Guerrero-Velázquez C, Guzmán-Flores JM. Alteration of cytokines in saliva of children with caries and obesity. Odontology. 2021; 109(1):11–17. Ramírez-De Los Santos S, López-Pulido EI, Medrano-González IDC, Becerra-Ruiz JS, Alonso-Sanchez CC, Vázquez-Jiménez SI, Guerrero-Velázquez C, Guzmán-Flores JM. Alteration of cytokines in saliva of children with caries and obesity. Odontology. 2021; 109(1):11–17.
6.
Zurück zum Zitat Jung MH, Ihm SH, Lee DH, Han S, Jung HO, Youn HJ, Ryu KH. Sex-specific associations of obesity with exercise capacity and diastolic function in Koreans. Nutr Metab Cardiovasc Dis. 2021;31(1):254–62.CrossRef Jung MH, Ihm SH, Lee DH, Han S, Jung HO, Youn HJ, Ryu KH. Sex-specific associations of obesity with exercise capacity and diastolic function in Koreans. Nutr Metab Cardiovasc Dis. 2021;31(1):254–62.CrossRef
7.
Zurück zum Zitat Li Z, Li J, Miao X, Cui W, Miao L, Cai L. A mini-review: Role of AMP-activated protein kinase (AMPK) signaling in obesity-related renal injury. Life Sci. 2021; 265:118828. Li Z, Li J, Miao X, Cui W, Miao L, Cai L. A mini-review: Role of AMP-activated protein kinase (AMPK) signaling in obesity-related renal injury. Life Sci. 2021; 265:118828.
8.
Zurück zum Zitat Khattab R, Eskin M, Aliani M, Thiyam U. Determination of sinapic acid derivatives in canola extracts using highperformance liquid chromatography. J Am Oil Chem. Soc, 2010; 87(2):147e55. Khattab R, Eskin M, Aliani M, Thiyam U. Determination of sinapic acid derivatives in canola extracts using highperformance liquid chromatography. J Am Oil Chem. Soc, 2010; 87(2):147e55.
9.
Zurück zum Zitat Huang YP, Lai HM. Bioactive compounds and antioxidative activity of colored rice bran. J Food Drug Anal. 2016; 24(3):564e74. Huang YP, Lai HM. Bioactive compounds and antioxidative activity of colored rice bran. J Food Drug Anal. 2016; 24(3):564e74.
10.
Zurück zum Zitat Idehen E, Tang Y, Sang S. Bioactive phytochemicals in barley. J Food Drug Anal. 2017; 25(1):148e61. Idehen E, Tang Y, Sang S. Bioactive phytochemicals in barley. J Food Drug Anal. 2017; 25(1):148e61.
11.
Zurück zum Zitat Ishaq M, Mehmood A, Rehman AU, Zad OD, Li J, Zhao L, Wang C, Hossen I, Naveed M, Lian Y. Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants. J. Food Biochem. 2020; 44(2):e13111. Ishaq M, Mehmood A, Rehman AU, Zad OD, Li J, Zhao L, Wang C, Hossen I, Naveed M, Lian Y. Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants. J. Food Biochem. 2020; 44(2):e13111.
12.
Zurück zum Zitat Bin Jardan YA., Ansari MA, Raish M, Alkharfy KM, Ahad A, Al-Jenoobi FI, Haq N, Khan MR, Ahmad A. Sinapic acid ameliorates oxidative stress, inflammation, and apoptosis in acute doxorubicin-induced cardiotoxicity via the NF-κB-mediated pathway. BioMed Res Int. 2020, 3921796. Bin Jardan YA., Ansari MA, Raish M, Alkharfy KM, Ahad A, Al-Jenoobi FI, Haq N, Khan MR, Ahmad A. Sinapic acid ameliorates oxidative stress, inflammation, and apoptosis in acute doxorubicin-induced cardiotoxicity via the NF-κB-mediated pathway. BioMed Res Int. 2020, 3921796.
13.
Zurück zum Zitat Singh HP, Singh TG, Singh R. Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats. J Pharm Bioallied Sci. 2020;12(2):146–54.CrossRef Singh HP, Singh TG, Singh R. Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats. J Pharm Bioallied Sci. 2020;12(2):146–54.CrossRef
14.
Zurück zum Zitat Deseo MA, Elkins A, Rochfort S, Kitchen B. Antioxidant activity and polyphenol composition of sugarcane molasses extract. Food Chem. 2020; 314, 126180. Deseo MA, Elkins A, Rochfort S, Kitchen B. Antioxidant activity and polyphenol composition of sugarcane molasses extract. Food Chem. 2020; 314, 126180.
15.
Zurück zum Zitat Landberg R, Sunnerheim K, Dimberg LH. Avenanthramides as lipoxygenase inhibitors. Heliyon 2020; 6(6):e04304. Landberg R, Sunnerheim K, Dimberg LH. Avenanthramides as lipoxygenase inhibitors. Heliyon 2020; 6(6):e04304.
16.
Zurück zum Zitat Bhanuvalli RS, Lotha R, Sivasubramanian A. Phenyl propanoid rich extract of edible plant Halosarcia indica exert diuretic, analgesic, and anti-inflammatory activity on Wistar albino rats. Nat Prod Res. 2020;34(11):1616–20.CrossRef Bhanuvalli RS, Lotha R, Sivasubramanian A. Phenyl propanoid rich extract of edible plant Halosarcia indica exert diuretic, analgesic, and anti-inflammatory activity on Wistar albino rats. Nat Prod Res. 2020;34(11):1616–20.CrossRef
17.
Zurück zum Zitat Lee JY. Anti-inflammatory effects of sinapic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice. Arch Pharm Res. 2018;41(2):243–50.CrossRef Lee JY. Anti-inflammatory effects of sinapic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice. Arch Pharm Res. 2018;41(2):243–50.CrossRef
18.
Zurück zum Zitat Ney DM, Laskan JB, Scinnich FL. Soluble oat fiber tends to normalize lipoprotein composition in cholesterol-fed rats. J Nutr. 1988;118(12):1455–62.CrossRef Ney DM, Laskan JB, Scinnich FL. Soluble oat fiber tends to normalize lipoprotein composition in cholesterol-fed rats. J Nutr. 1988;118(12):1455–62.CrossRef
19.
Zurück zum Zitat Ding SL, Chi MM, Scull BP, Rigby R, Schwerbrock NMJ, Magness S, Jobin C, Lund PK. High-Fat Diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PloS one. 2010; 5(8). Ding SL, Chi MM, Scull BP, Rigby R, Schwerbrock NMJ, Magness S, Jobin C, Lund PK. High-Fat Diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PloS one. 2010; 5(8).
20.
Zurück zum Zitat Conway B, Rene A. Obesity as a disease: no lightweight matter. Obes Rev. 2004;5(3):145–51.CrossRef Conway B, Rene A. Obesity as a disease: no lightweight matter. Obes Rev. 2004;5(3):145–51.CrossRef
21.
Zurück zum Zitat Koriem KMM. A lipidomic concept in infectious diseases. Asian Pac J Trop Biomed. 2017;7:265–74.CrossRef Koriem KMM. A lipidomic concept in infectious diseases. Asian Pac J Trop Biomed. 2017;7:265–74.CrossRef
22.
Zurück zum Zitat Koriem KMM. Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review. World J Gastroenterol. 2021;27:37–54.CrossRef Koriem KMM. Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review. World J Gastroenterol. 2021;27:37–54.CrossRef
23.
Zurück zum Zitat Roy SJ, Stanely Mainzen Prince P. Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Food Chem Toxicol. 2012; 50(11):3984–3989. Roy SJ, Stanely Mainzen Prince P. Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Food Chem Toxicol. 2012; 50(11):3984–3989.
24.
Zurück zum Zitat Roy SJ, Stanely Mainzen Prince P. Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. Eur J Pharmacol. 2013; 699(1–3):213–218. Roy SJ, Stanely Mainzen Prince P. Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. Eur J Pharmacol. 2013; 699(1–3):213–218.
25.
Zurück zum Zitat Pari L, Mohamed JA. Protective role of sinapic acid against arsenic: induced toxicity in rats. Chem Biol Interact. 2011;194(1):40–7.CrossRef Pari L, Mohamed JA. Protective role of sinapic acid against arsenic: induced toxicity in rats. Chem Biol Interact. 2011;194(1):40–7.CrossRef
26.
Zurück zum Zitat Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. The effects of sinapic acid on the development of metabolic disorders induced by estrogen deficiency in rats. Oxid Med Cell Longev. 2018;2018:9274246.CrossRef Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. The effects of sinapic acid on the development of metabolic disorders induced by estrogen deficiency in rats. Oxid Med Cell Longev. 2018;2018:9274246.CrossRef
27.
Zurück zum Zitat Koriem KMM. Protective effect of natural products and hormones in colon cancer using metabolome: A physiological overview. Asian Pac J Trop Biomed. 2017;7(10):957–66.CrossRef Koriem KMM. Protective effect of natural products and hormones in colon cancer using metabolome: A physiological overview. Asian Pac J Trop Biomed. 2017;7(10):957–66.CrossRef
28.
Zurück zum Zitat Koriem KMM. Antihyperlipidemic activity of the medicinal plants among Kadazan and Dusun communities in Sabah, Malaysia: A review. Asian Pac J Trop Biomed. 2014;4(10):768–79.CrossRef Koriem KMM. Antihyperlipidemic activity of the medicinal plants among Kadazan and Dusun communities in Sabah, Malaysia: A review. Asian Pac J Trop Biomed. 2014;4(10):768–79.CrossRef
29.
Zurück zum Zitat Alvarez P, Alvarado C, Mathieu F, Jiménez L, De la Fuente M. Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes. Eur J Nutr. 2006;45(8):428–38.CrossRef Alvarez P, Alvarado C, Mathieu F, Jiménez L, De la Fuente M. Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes. Eur J Nutr. 2006;45(8):428–38.CrossRef
30.
Zurück zum Zitat Alvarez P, Alvarado C, Puerto M, Schlumberger A, Jiménez L, De la Fuente M. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutrition. 2006;22(9):913–21.CrossRef Alvarez P, Alvarado C, Puerto M, Schlumberger A, Jiménez L, De la Fuente M. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutrition. 2006;22(9):913–21.CrossRef
31.
Zurück zum Zitat Zych M, Wojnar W, Borymski S, Szałabska K, Bramora P, Kaczmarczyk-Sedlak I. Effect of rosmarinic acid and sinapic acid on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Antioxidants (Basel). 2019;8(12):579.CrossRef Zych M, Wojnar W, Borymski S, Szałabska K, Bramora P, Kaczmarczyk-Sedlak I. Effect of rosmarinic acid and sinapic acid on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Antioxidants (Basel). 2019;8(12):579.CrossRef
32.
Zurück zum Zitat Alaofi AL. Sinapic acid ameliorates the progression of streptozotocin (STZ)-induced diabetic nephropathy in rats via NRF2/HO-1 mediated pathways. Front Pharmacol. 2020;11:1119.CrossRef Alaofi AL. Sinapic acid ameliorates the progression of streptozotocin (STZ)-induced diabetic nephropathy in rats via NRF2/HO-1 mediated pathways. Front Pharmacol. 2020;11:1119.CrossRef
33.
Zurück zum Zitat Sharma I, Aaradhya M, Kodikonda M, Naik PR. Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats. Springerplus. 2015;4:212.CrossRef Sharma I, Aaradhya M, Kodikonda M, Naik PR. Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats. Springerplus. 2015;4:212.CrossRef
34.
Zurück zum Zitat El Hilaly J, Israili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajugaiva in experimental animals. J Ethnopharmacol. 2004;91(1):43–50.CrossRef El Hilaly J, Israili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajugaiva in experimental animals. J Ethnopharmacol. 2004;91(1):43–50.CrossRef
35.
Zurück zum Zitat Rahman MF. Effects of Vepacide (Azadirachta indica) on aspartate and alanine aminotransferase profiles in a sub-chronic study with rats. Hum Exp Toxicol. 2001;20(5):243–9.CrossRef Rahman MF. Effects of Vepacide (Azadirachta indica) on aspartate and alanine aminotransferase profiles in a sub-chronic study with rats. Hum Exp Toxicol. 2001;20(5):243–9.CrossRef
36.
Zurück zum Zitat Martin P, Friedman LS. In: Friedmann LS, Kaffee EB, editors. Handbook of liver disease. Philadelphia: Churchill Livingstone; 1988. p. 1–14. Martin P, Friedman LS. In: Friedmann LS, Kaffee EB, editors. Handbook of liver disease. Philadelphia: Churchill Livingstone; 1988. p. 1–14.
37.
Zurück zum Zitat Plaa GL, Hewitt WR. In: Hayes WA, editor. Principles and methods of toxicology. 2nd ed. NewYork (NY): Raven Press; 1989. p. 599–605. Plaa GL, Hewitt WR. In: Hayes WA, editor. Principles and methods of toxicology. 2nd ed. NewYork (NY): Raven Press; 1989. p. 599–605.
38.
Zurück zum Zitat Barnett LMA, Cummings BS. Nephrotoxicity and Renal Pathophysiology: A Contemporary Perspective. Toxicol Sci. 2018;164(2):379–90.CrossRef Barnett LMA, Cummings BS. Nephrotoxicity and Renal Pathophysiology: A Contemporary Perspective. Toxicol Sci. 2018;164(2):379–90.CrossRef
39.
Zurück zum Zitat Atshaves BP, Martin GG, Hostetler HA, McIntosh AL, Kier AB, Schroeder F. Liver fatty acid-binding protein and obesity. J Nutr Biochem. 2010;21(11):1015–32.CrossRef Atshaves BP, Martin GG, Hostetler HA, McIntosh AL, Kier AB, Schroeder F. Liver fatty acid-binding protein and obesity. J Nutr Biochem. 2010;21(11):1015–32.CrossRef
40.
Zurück zum Zitat Corcoran GB, Wong BK. Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther. 1987;241(3):921–7.PubMed Corcoran GB, Wong BK. Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther. 1987;241(3):921–7.PubMed
41.
Zurück zum Zitat Shin DS, Kim KW, Chung HY, Yoon S, Moon JO. Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats. Arch Pharm Res. 2013;36(5):608–18.CrossRef Shin DS, Kim KW, Chung HY, Yoon S, Moon JO. Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats. Arch Pharm Res. 2013;36(5):608–18.CrossRef
42.
Zurück zum Zitat Shin DS, Kim KW, Chung HY, Yoon S, Moon JO. Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats. Arch Pharm Res. 2013;36(5):626–33.CrossRef Shin DS, Kim KW, Chung HY, Yoon S, Moon JO. Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats. Arch Pharm Res. 2013;36(5):626–33.CrossRef
43.
Zurück zum Zitat Hegazy AM, Abdel-Azeem AS, Zeidan HM, Ibrahim KS, Sayed EE. Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats. Hum Exp Toxicol. 2018;37(4):420–30.CrossRef Hegazy AM, Abdel-Azeem AS, Zeidan HM, Ibrahim KS, Sayed EE. Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats. Hum Exp Toxicol. 2018;37(4):420–30.CrossRef
44.
Zurück zum Zitat Ansari MA, Raish M, Ahmad A, Alkharfy KM, Ahmad SF, Attia SM, Alsaad AMS, Bakheet SA. Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-kappaB downregulation. Environ Toxicol Pharmacol. 2017;51:100–7.CrossRef Ansari MA, Raish M, Ahmad A, Alkharfy KM, Ahmad SF, Attia SM, Alsaad AMS, Bakheet SA. Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-kappaB downregulation. Environ Toxicol Pharmacol. 2017;51:100–7.CrossRef
45.
Zurück zum Zitat Koriem KMM, Arbid MS, Saleh HN. Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats. J Integr Med. 2019;17(1):57–65.CrossRef Koriem KMM, Arbid MS, Saleh HN. Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats. J Integr Med. 2019;17(1):57–65.CrossRef
46.
Zurück zum Zitat Monien BH, Henry BL, Raghuraman A, Hindle M, Desai UR. Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases. Bioorg Med Chem. 2006;14(23):7988–98.CrossRef Monien BH, Henry BL, Raghuraman A, Hindle M, Desai UR. Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases. Bioorg Med Chem. 2006;14(23):7988–98.CrossRef
47.
Zurück zum Zitat Bae IS, Kim SH. Sinapic acid promotes browning of 3T3-L1 adipocytes via p38 MAPK/CREB Pathway. Biomed Res Int. 2020;2020:5753623.PubMedPubMedCentral Bae IS, Kim SH. Sinapic acid promotes browning of 3T3-L1 adipocytes via p38 MAPK/CREB Pathway. Biomed Res Int. 2020;2020:5753623.PubMedPubMedCentral
48.
Zurück zum Zitat Hussain S, Rehman AU, Luckett DJ, Blanchard CL, Obied HK, Strappe P. Phenolic compounds with antioxidant properties from Canola Meal extracts inhibit adipogenesis. Int J Mol Sci. 2019;21(1):1.CrossRef Hussain S, Rehman AU, Luckett DJ, Blanchard CL, Obied HK, Strappe P. Phenolic compounds with antioxidant properties from Canola Meal extracts inhibit adipogenesis. Int J Mol Sci. 2019;21(1):1.CrossRef
Metadaten
Titel
Sinapic acid restores blood parameters, serum antioxidants, and liver and kidney functions in obesity
verfasst von
Khaled M. M. Koriem
Islam B. Gad
Publikationsdatum
06.01.2022
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2022
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-022-00972-x

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Metastasiertes CRC: besser Checkpointhemmer im Doppelpack!

Die Kombination von Nivolumab plus Ipilimumab ist beim metastasierten Kolorektalkarzinom mit MSI-H- oder dMMR klar im Vorteil gegenüber einer Nivolumab-Monotherapie: Das Progressionsrisiko war damit in einer Phase-3-Studie um 38% reduziert.

Riesenzellarteriitis: bilaterale Biopsie der Temporalarterien von Vorteil

Die Riesenzellarteriitis (RZA) erfordert eine rasche und präzise Diagnose, da innerhalb weniger Tage ein schwerer, irreversibler Sehverlust drohen kann. In diesem Zusammenhang scheint die bilaterale Biopsie der Temporalarterien (TAB) der unilateralen überlegen zu sein.

Große Trinkmengen bei Blasentumoren möglicherweise von Nachteil

Beim nicht-muskelinvasiven Blasenkrebs scheint eine hohe Flüssigkeitszufuhr keinen schützenden Effekt in Bezug auf das Risiko eines Rezidivs oder einer Krankheitsprogression zu haben. Eine niederländische Studie legt sogar nahe, dass große Trinkmengen das Fortschreiten der Erkrankung begünstigen könnten.

Höhere Trefferquoten bei Brustkrebsscreening dank KI?

Künstliche Intelligenz unterstützt bei der Auswertung von Mammografie-Screenings und senkt somit den Arbeitsaufwand für Radiologen. Wie wirken sich diese Technologien auf die Trefferquote und die Falsch-positiv-Rate aus? Das hat jetzt eine Studie aus Schweden untersucht.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.