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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 3/2010

01.10.2010 | American Society of Breast Surgeons

Single-Center Long-Term Follow-Up After Intraoperative Radiotherapy as a Boost During Breast-Conserving Surgery Using Low-Kilovoltage X-Rays

verfasst von: Elena Blank, MD, Uta Kraus-Tiefenbacher, MD, Grit Welzel, MS, Anke Keller, MS, Markus Bohrer, MD, Marc Sütterlin, MD, Frederik Wenz, MD

Erschienen in: Annals of Surgical Oncology | Sonderheft 3/2010

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Abstract

Background

Intraoperative radiotherapy (IORT) during breast-conserving surgery as a boost followed by whole-breast radiotherapy is increasingly used.

Methods

Between February 2002 and December 2008, a total of 197 patients were treated with IORT as a boost (20 Gy, 50 kV x-rays; Intrabeam System, Carl Zeiss Surgical, Oberkochen, Germany) during breast-conserving surgery, followed by whole-breast radiotherapy (46–50 Gy). Systemic therapy was provided according to the St. Gallen consensus. Patients were recalled every 6–12 months for follow-up. Findings were scored according to the LENT-SOMA scale.

Results

Median age was 61.8 (range 30–84) years, and median follow-up was 37 (range 5–91) months. There were T1, T2, and Tx tumors in 129, 67, and 1 patients, respectively, and N0, N1, N2, and N3 disease in 144, 36, 15, and 2 patients, respectively. Until December 2009, 5 local invasive relapses, 1 local ductal carcinoma-in-situ, 1 axillary relapse, 6 secondary cancers, and 11 distant metastases were seen, resulting in a 5-year disease-free survival of 81.0% and an overall survival of 91.3%. Local relapse-free survival (invasive cancers) at 3 and 5 years was 97.0%. After a follow-up of 5 years (n = 58), only 8 patients (13.8%) had chronic skin toxicities, and 2 patients (3.4%) had a marked increase in density (fibrosis III), while 62.0% had no/barely palpable fibrosis 0–I. Other toxicities observed included severe pain (n = 4, 6.9%), retraction (n = 17, 29.3%), edema of the breast (n = 1, 1.7%), and lymphedema in general (n = 2, 3.4%).

Conclusions

After IORT as a tumor bed boost with low-kilovoltage x-rays followed by whole-breast radiotherapy, low local recurrence and chronic toxicity rates were seen after 5-year follow-up.
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Metadaten
Titel
Single-Center Long-Term Follow-Up After Intraoperative Radiotherapy as a Boost During Breast-Conserving Surgery Using Low-Kilovoltage X-Rays
verfasst von
Elena Blank, MD
Uta Kraus-Tiefenbacher, MD
Grit Welzel, MS
Anke Keller, MS
Markus Bohrer, MD
Marc Sütterlin, MD
Frederik Wenz, MD
Publikationsdatum
01.10.2010
Verlag
Springer-Verlag
Erschienen in
Annals of Surgical Oncology / Ausgabe Sonderheft 3/2010
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1265-z

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