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Erschienen in: Langenbeck's Archives of Surgery 8/2019

27.08.2019 | Original Article

Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation

verfasst von: Bernd Martin Jänigen, Chiara Salabè, Torben Glatz, Oliver Thomusch, Claudia Lässle, Stefan Fichtner-Feigl, Stefan Zschiedrich, Przemyslaw Pisarski

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 8/2019

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Abstract

Purpose

Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele formation, only scarce data exist.

Methods

Between April 2004 and September 2015, 106 consecutive ABOi and 277 consecutive ABO-compatible kidney transplantations (ABOc KTx) were performed. Two ABOi and 117 ABOc recipients were excluded due to differences in immunosuppression. One hundred-four ABOi and 160 ABOc KTx patients were analyzed concerning lymphocele formation.

Results

The incidence of lymphoceles in ABOi KTx was 25.2% and 10.6% in ABOc KTx (p = 0.003). A major risk factor appeared the frequency of ≥ 8 preoperative immunoadsorption and/or plasmapheresis sessions (OR 5.61, 95% CI 2.31–13.61, p < 0.001). Particularly, these ABOi KTx recipients had a distinctly higher risk of developing lymphocele (40.0% vs. 19.2%, p = 0.044). IA/PE sessions on day of transplantation (no lymphocele 20.0% vs. lymphocele 28.6%, p = 0.362) or postoperative IA/PE sessions (no lymphocele 25.7% vs. lymphocele 24.1%, p = 1.0) showed no influence on formation of lymphoceles.

Conclusion

In ABOi KTx, the incidence of lymphocele formation is significantly increased compared to ABOc KTx and leads to more frequent surgical reinterventions without having an impact on graft survival.
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Metadaten
Titel
Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation
verfasst von
Bernd Martin Jänigen
Chiara Salabè
Torben Glatz
Oliver Thomusch
Claudia Lässle
Stefan Fichtner-Feigl
Stefan Zschiedrich
Przemyslaw Pisarski
Publikationsdatum
27.08.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Langenbeck's Archives of Surgery / Ausgabe 8/2019
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-019-01812-y

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