Skip to main content
Erschienen in: gynäkologie + geburtshilfe 4/2019

05.07.2019 | Fortbildung

Vitamin- und Mineralstoffpräparate

Sinn und Unsinn von Supplementierung in der Onkologie

verfasst von: Prof. Dr. med. Karsten Münstedt

Erschienen in: gynäkologie + geburtshilfe | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Gerade onkologische Patienten setzen oft große Hoffnungen auf im Internet be- und erworbene Nahrungsergänzungsmittel. Die Datenlage zum Nutzen der Supplementierung ist jedoch dünn — und „viel hilft viel“ gilt hier keinesfalls. Vielmehr birgt Überversorgung häufig unabwägbare Risiken.
Literatur
1.
Zurück zum Zitat Drozdoff L et al. Use of biologically-based complementary medicine in breast and gynecological cancer patients during systemic therapy. BMC Complement Altern Med. 2018; 18: 259CrossRef Drozdoff L et al. Use of biologically-based complementary medicine in breast and gynecological cancer patients during systemic therapy. BMC Complement Altern Med. 2018; 18: 259CrossRef
2.
Zurück zum Zitat Fremd C et al. Use of complementary and integrative medicine among German breast cancer patients: predictors and implications for patient care within the PRAEGNANT study network. Arch Gynecol Obstet. 2017; 295: 1239–45CrossRef Fremd C et al. Use of complementary and integrative medicine among German breast cancer patients: predictors and implications for patient care within the PRAEGNANT study network. Arch Gynecol Obstet. 2017; 295: 1239–45CrossRef
3.
Zurück zum Zitat Münstedt K et al. Unconventional cancer therapy—survey of patients with gynaecological malignancy. Arch Gynecol Obstet. 1996; 258: 81–8PubMed Münstedt K et al. Unconventional cancer therapy—survey of patients with gynaecological malignancy. Arch Gynecol Obstet. 1996; 258: 81–8PubMed
4.
Zurück zum Zitat https://www.iqvia.com/media/iqvia/pdfs/cese/germany/publikationen/infografik/nahrungsergnzungsmittel-infografik-iqvia-052018.pdf?la=de-de&hash=FF5C297D9F0744CFB2D59EAE2436DC1A7D8CC217&_=1528367860467; zugegriffen am 27.2.2019 https://​www.​iqvia.​com/media/iqvia/pdfs/cese/germany/publikationen/infografik/nahrungsergnzungsmittel-infografik-iqvia-052018.pdf?la=de-de&hash=FF5C297D9F0744CFB2D59EAE2436DC1A7D8CC217&_=1528367860467; zugegriffen am 27.2.2019
5.
Zurück zum Zitat Calabrese EJ et al. U-shaped dose-responses in biology, toxicology, and public health. Annu Rev Public Health. 2001; 22: 15–33CrossRef Calabrese EJ et al. U-shaped dose-responses in biology, toxicology, and public health. Annu Rev Public Health. 2001; 22: 15–33CrossRef
7.
Zurück zum Zitat Goodwin PJ et al. Diet and breast cancer: evidence that extremes in diet are associated with poor survival. J Clin Oncol. 2003; 21: 2500–7CrossRef Goodwin PJ et al. Diet and breast cancer: evidence that extremes in diet are associated with poor survival. J Clin Oncol. 2003; 21: 2500–7CrossRef
8.
Zurück zum Zitat Goyal A et al. Serum antioxidant nutrients, vitamin A, and mortality in U.S. Adults. Cancer Epidemiol Biomarkers Prev. 2013; 22: 2202–11CrossRef Goyal A et al. Serum antioxidant nutrients, vitamin A, and mortality in U.S. Adults. Cancer Epidemiol Biomarkers Prev. 2013; 22: 2202–11CrossRef
9.
Zurück zum Zitat Mücke R et al. Selenium in radiation oncology-15 years of experiences in Germany. Nutrients. 2018; http://doi.org/c258 Mücke R et al. Selenium in radiation oncology-15 years of experiences in Germany. Nutrients. 2018; http://​doi.​org/​c258
10.
Zurück zum Zitat Biesalski HK, Tinz J. Multivitamin/mineral supplements: Rationale and safety — a systematic review. Nutrition. 2017; 33: 76–82CrossRef Biesalski HK, Tinz J. Multivitamin/mineral supplements: Rationale and safety — a systematic review. Nutrition. 2017; 33: 76–82CrossRef
11.
Zurück zum Zitat Perna L et al. Public health implications of standardized 25-hydroxyvitamin D levels: a decrease in the prevalence of vitamin D deficiency among older women in Germany. Prev Med. 2012; 55: 228–32CrossRef Perna L et al. Public health implications of standardized 25-hydroxyvitamin D levels: a decrease in the prevalence of vitamin D deficiency among older women in Germany. Prev Med. 2012; 55: 228–32CrossRef
12.
Zurück zum Zitat Troesch B et al. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr. 2012; 108: 692–8CrossRef Troesch B et al. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr. 2012; 108: 692–8CrossRef
13.
Zurück zum Zitat Liu Z et al. Trace elements and chemotherapy sensitivity. Biol Trace Elem Res. 2016; 173: 283–90CrossRef Liu Z et al. Trace elements and chemotherapy sensitivity. Biol Trace Elem Res. 2016; 173: 283–90CrossRef
14.
Zurück zum Zitat Vadgama JV et al. Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res. 2000; 20: 1391–414PubMed Vadgama JV et al. Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res. 2000; 20: 1391–414PubMed
15.
Zurück zum Zitat Li Z et al. Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells. Mol Cancer Ther. 2008; 7: 3056–63CrossRef Li Z et al. Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells. Mol Cancer Ther. 2008; 7: 3056–63CrossRef
16.
Zurück zum Zitat Vieira ML et al. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer. J Med Food. 2015; 18: 109–17CrossRef Vieira ML et al. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer. J Med Food. 2015; 18: 109–17CrossRef
17.
Zurück zum Zitat Sieja K, Talerczyk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol. 2004; 93: 320–7CrossRef Sieja K, Talerczyk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol. 2004; 93: 320–7CrossRef
18.
Zurück zum Zitat Lippman SM et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009; 301: 39–51CrossRef Lippman SM et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009; 301: 39–51CrossRef
19.
Zurück zum Zitat Grant WB. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 2011; 65: 1016–26CrossRef Grant WB. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 2011; 65: 1016–26CrossRef
20.
Zurück zum Zitat Zheng Y et al. Meta-analysis of long-term vitamin D supplementation on overall mortality. PLoS One. 2013; http://doi.org/c26b Zheng Y et al. Meta-analysis of long-term vitamin D supplementation on overall mortality. PLoS One. 2013; http://​doi.​org/​c26b
21.
Zurück zum Zitat Ditsch N et al. The association between vitamin D receptor expression and prolonged overall survival in breast cancer. J Histochem Cytochem. 2012; 60: 121–9CrossRef Ditsch N et al. The association between vitamin D receptor expression and prolonged overall survival in breast cancer. J Histochem Cytochem. 2012; 60: 121–9CrossRef
22.
Zurück zum Zitat Li M et al. Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014; 99: 2327–36CrossRef Li M et al. Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014; 99: 2327–36CrossRef
23.
Zurück zum Zitat Maalmi H et al. Association between blood 25-hydroxyvitamin D levels and survival in colorectal cancer patients: an updated systematic review and meta-analysis. Nutrients. 2018; http://doi.org/c259 Maalmi H et al. Association between blood 25-hydroxyvitamin D levels and survival in colorectal cancer patients: an updated systematic review and meta-analysis. Nutrients. 2018; http://​doi.​org/​c259
24.
Zurück zum Zitat Bittenbring JT et al. Vitamin d deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab. J Clin Oncol. 2014; 32: 3242–8CrossRef Bittenbring JT et al. Vitamin d deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab. J Clin Oncol. 2014; 32: 3242–8CrossRef
27.
Zurück zum Zitat Chiba A et al. Serum vitamin D levels affect pathologic complete response in patients undergoing neoadjuvant systemic therapy for operable breast cancer. Clin Breast Cancer. 2018; 18: 144–9CrossRef Chiba A et al. Serum vitamin D levels affect pathologic complete response in patients undergoing neoadjuvant systemic therapy for operable breast cancer. Clin Breast Cancer. 2018; 18: 144–9CrossRef
28.
Zurück zum Zitat Shahvazi S et al. The effect of vitamin D supplementation on prostate cancer: a systematic review and meta-analysis of clinical trials. Horm Metab Res. 2019; 51: 11–21CrossRef Shahvazi S et al. The effect of vitamin D supplementation on prostate cancer: a systematic review and meta-analysis of clinical trials. Horm Metab Res. 2019; 51: 11–21CrossRef
29.
Zurück zum Zitat Hu X et al. Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies. PLoS One. 2017; http://doi.org/gbsvsr Hu X et al. Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies. PLoS One. 2017; http://​doi.​org/​gbsvsr
30.
Zurück zum Zitat Goh YI et al. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol Ther. 2007; 81: 685–91CrossRef Goh YI et al. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol Ther. 2007; 81: 685–91CrossRef
31.
Zurück zum Zitat Veettil SK et al. Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials. Medicine (Baltimore). 2017; http://doi.org/c257 Veettil SK et al. Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials. Medicine (Baltimore). 2017; http://​doi.​org/​c257
32.
Zurück zum Zitat Seely D et al. Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials. Integr Cancer Ther. 2012; 11: 293–303CrossRef Seely D et al. Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials. Integr Cancer Ther. 2012; 11: 293–303CrossRef
33.
Zurück zum Zitat Harris HR et al. Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer. 2014; 50: 1223–31CrossRef Harris HR et al. Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer. 2014; 50: 1223–31CrossRef
34.
Zurück zum Zitat Kraft M et al. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)- a randomized multicentre trial. Nutr J. 2012; 11: 52CrossRef Kraft M et al. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)- a randomized multicentre trial. Nutr J. 2012; 11: 52CrossRef
35.
Zurück zum Zitat Hershman DL et al. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. J Clin Oncol. 2013; 31: 2627–33CrossRef Hershman DL et al. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. J Clin Oncol. 2013; 31: 2627–33CrossRef
36.
Zurück zum Zitat Marx W et al. Efficacy and effectiveness of carnitine supplementation for cancer-related fatigue: a systematic literature review and meta-analysis. Nutrients. 2017; http://doi.org/c26c Marx W et al. Efficacy and effectiveness of carnitine supplementation for cancer-related fatigue: a systematic literature review and meta-analysis. Nutrients. 2017; http://​doi.​org/​c26c
37.
Zurück zum Zitat Bjelakovic G et al. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013; http://doi.org/c26d Bjelakovic G et al. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013; http://​doi.​org/​c26d
38.
Zurück zum Zitat Tanvetyanon T et al. Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers: a meta-analysis and evaluation of national brands. Cancer. 2008; 113: 150–7CrossRef Tanvetyanon T et al. Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers: a meta-analysis and evaluation of national brands. Cancer. 2008; 113: 150–7CrossRef
39.
Zurück zum Zitat Klein EA et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011; 306: 1549–56CrossRef Klein EA et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011; 306: 1549–56CrossRef
40.
Zurück zum Zitat Miller ER 3rd et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005; 142: 37–46CrossRef Miller ER 3rd et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005; 142: 37–46CrossRef
41.
Zurück zum Zitat Bjelakovic G et al. Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma. Aliment Pharmacol Ther. 2006; 24: 281–91CrossRef Bjelakovic G et al. Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma. Aliment Pharmacol Ther. 2006; 24: 281–91CrossRef
42.
Zurück zum Zitat Macpherson H et al. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2013; 97: 437–44CrossRef Macpherson H et al. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2013; 97: 437–44CrossRef
43.
Zurück zum Zitat Zhang SL et al. Effect of vitamin B supplementation on cancer incidence, death due to cancer, and total mortality: A PRISMA-compliant cumulative meta-analysis of randomized controlled trials. Medicine (Baltimore). 2016; http://doi.org/c26f Zhang SL et al. Effect of vitamin B supplementation on cancer incidence, death due to cancer, and total mortality: A PRISMA-compliant cumulative meta-analysis of randomized controlled trials. Medicine (Baltimore). 2016; http://​doi.​org/​c26f
44.
Zurück zum Zitat Jacobs C et al. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist. 2015; 20: 210–23CrossRef Jacobs C et al. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist. 2015; 20: 210–23CrossRef
45.
Zurück zum Zitat Kim K et al. High-dose vitamin C injection to cancer patients may promote thrombosis through procoagulant activation of erythrocytes. Toxicol Sci. 2015; 147: 350–9CrossRef Kim K et al. High-dose vitamin C injection to cancer patients may promote thrombosis through procoagulant activation of erythrocytes. Toxicol Sci. 2015; 147: 350–9CrossRef
46.
Zurück zum Zitat Colliou E et al. Oxalate nephropathy following vitamin C intake within intensive care unit. Clin Nephrol. 2017; 88: 354–8CrossRef Colliou E et al. Oxalate nephropathy following vitamin C intake within intensive care unit. Clin Nephrol. 2017; 88: 354–8CrossRef
47.
Zurück zum Zitat Mochamat et al. A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project. J Cachexia Sarcopenia Muscle. 2017; 8: 25–39CrossRef Mochamat et al. A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project. J Cachexia Sarcopenia Muscle. 2017; 8: 25–39CrossRef
Metadaten
Titel
Vitamin- und Mineralstoffpräparate
Sinn und Unsinn von Supplementierung in der Onkologie
verfasst von
Prof. Dr. med. Karsten Münstedt
Publikationsdatum
05.07.2019
Verlag
Springer Medizin
Erschienen in
gynäkologie + geburtshilfe / Ausgabe 4/2019
Print ISSN: 1439-3557
Elektronische ISSN: 2196-6435
DOI
https://doi.org/10.1007/s15013-019-1769-y

Weitere Artikel der Ausgabe 4/2019

gynäkologie + geburtshilfe 4/2019 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.