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Erschienen in: Head and Neck Pathology 3/2016

16.01.2016 | Case Report

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

verfasst von: Binay Kumar, Bhawna Pant, Vikrant Kumar, Meghna Negi

Erschienen in: Head and Neck Pathology | Ausgabe 3/2016

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Abstract

Primary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharyngeal malignancy. The definitive diagnosis in such cases depends upon histopathology and further confirmed by immunohistochemistry. A 55-year old male presented with recurrent episodes of nasal bleed, bilateral nasal obstruction, and bilateral hearing loss from last 7 years. On clinical examination a mass was found in the nasal cavity on both sides reaching up to the nasopharynx. Contrast enhanced CT scan revealed that the mass was extending up to the skull base and destroying bony landmarks of the nasal cavity and paranasal sinuses. Mass was proved to be amyloidosis after histopathological examination. It showed multiple blotches of globular submucosal deposit of amyloid, on staining with Congo red. Immunohistochemistry confirmed AL amyloidosis with expression of mixed kappa and lambda light chain immunoglobulin (κ > λ). No evidence of systemic amyloidosis was found after proper work up. It was managed by conservative surgery.
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Metadaten
Titel
Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation
verfasst von
Binay Kumar
Bhawna Pant
Vikrant Kumar
Meghna Negi
Publikationsdatum
16.01.2016
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 3/2016
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-016-0681-1

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