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27.02.2024 | Case Report

Sinonasal NUT Carcinoma: A Call for Increased Attention to a Vital Clinical Diagnosis

verfasst von: Priti Chatterjee, Anita Nangia, Md Ali Osama, M. C. Sharma, Kartik Kolluru, Sunil Kumar

Erschienen in: Indian Journal of Surgical Oncology

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Abstract

Nuclear protein in testis (NUT) carcinoma is a highly aggressive and poorly differentiated carcinoma, defined by presence of NUT rearrangements in the NUTM1 (NUT midline carcinoma family member 1) gene. This tumor has a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and has a devastating clinical course, thus an early diagnosis is indispensable. However, due to its low incidence, this is often misdiagnosed by the clinicians and pathologists. Here, we report a case of NUT midline carcinoma of the nasal cavity in a 53-year-old man who presented with chief complaints of nasal discharge and obstruction, accompanied by blurring of vision and facial swelling. The present case report reviews the clinical characteristics, histopathological diagnosis of NUT carcinoma, highlighting the morphological and immunohistochemical findings and the pathological approach to sinonasal undifferentiated tumors encountered.
Literatur
1.
Zurück zum Zitat French CA (2018) NUT Carcinoma: clinicopathologic features, pathogenesis, and treatment. Pathol Int 68:583–595CrossRefPubMed French CA (2018) NUT Carcinoma: clinicopathologic features, pathogenesis, and treatment. Pathol Int 68:583–595CrossRefPubMed
2.
3.
Zurück zum Zitat Edgar M, Caruso AM, Kim E, Foss RD (2017) NUT midline carcinoma of the nasal cavity. Head Neck Pathol 11:389–392CrossRefPubMed Edgar M, Caruso AM, Kim E, Foss RD (2017) NUT midline carcinoma of the nasal cavity. Head Neck Pathol 11:389–392CrossRefPubMed
4.
Zurück zum Zitat El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ (2017) The fourth edition of the head and neck World Health Organization blue book: editors’ perspectives. Hum Pathol 66:10–12CrossRefPubMed El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ (2017) The fourth edition of the head and neck World Health Organization blue book: editors’ perspectives. Hum Pathol 66:10–12CrossRefPubMed
5.
Zurück zum Zitat Giridhar P, Mallick S, Kashyap L, Rath GK (2018) Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. Eur Arch Otorhinolaryngol 275:815–821CrossRefPubMed Giridhar P, Mallick S, Kashyap L, Rath GK (2018) Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. Eur Arch Otorhinolaryngol 275:815–821CrossRefPubMed
6.
Zurück zum Zitat Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA (2017) Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. Proc Natl Acad Sci U S A 114:E4184-E4192 Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA (2017) Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. Proc Natl Acad Sci U S A 114:E4184-E4192
7.
Zurück zum Zitat French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC (2008) BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:2237–2242CrossRefPubMed French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC (2008) BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:2237–2242CrossRefPubMed
8.
Zurück zum Zitat Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA (2019) An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients. JNCI Cancer Spectr 4:pkz094CrossRefPubMedPubMedCentral Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA (2019) An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients. JNCI Cancer Spectr 4:pkz094CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA (2012) Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res 18:5773–5779CrossRefPubMedPubMedCentral Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA (2012) Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res 18:5773–5779CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE (2010) Selective inhibition of BET bromodomains. Nature 468:1067–1073ADSCrossRefPubMedPubMedCentral Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE (2010) Selective inhibition of BET bromodomains. Nature 468:1067–1073ADSCrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Piha-Paul SA, Hann CL, French CA, Cousin S, Braña I, Cassier PA, Moreno V, de Bono JS, Harward SD, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Haas NB, Markowski MC, Dhar A, O’Dwyer PJ, Shapiro GI (2019) Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors. JNCI Cancer Spectr 4:pkz093CrossRefPubMedPubMedCentral Piha-Paul SA, Hann CL, French CA, Cousin S, Braña I, Cassier PA, Moreno V, de Bono JS, Harward SD, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Haas NB, Markowski MC, Dhar A, O’Dwyer PJ, Shapiro GI (2019) Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors. JNCI Cancer Spectr 4:pkz093CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA (2004) Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol 15(22):4135–4139CrossRef French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA (2004) Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol 15(22):4135–4139CrossRef
13.
Zurück zum Zitat Davis BN, Karabakhtsian RG, Pettigrew AL, Arnold SM, French CA, Brill YM (2011) Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity. Arch Pathol Lab Med 135:1494–1498CrossRefPubMed Davis BN, Karabakhtsian RG, Pettigrew AL, Arnold SM, French CA, Brill YM (2011) Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity. Arch Pathol Lab Med 135:1494–1498CrossRefPubMed
14.
Zurück zum Zitat Fang W, French CA, Cameron MJ, Han Y, Liu H (2013) Clinicopathological significance of NUT rearrangements in poorly differentiated malignant tumors of the upper respiratory tract. Int J Surg Pathol 21:102–110CrossRefPubMed Fang W, French CA, Cameron MJ, Han Y, Liu H (2013) Clinicopathological significance of NUT rearrangements in poorly differentiated malignant tumors of the upper respiratory tract. Int J Surg Pathol 21:102–110CrossRefPubMed
15.
Zurück zum Zitat Solomon LW, Magliocca KR, Cohen C, Müller S (2015) Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum. Oral Surg Oral Med Oral Pathol Oral Radiol 119:213–220CrossRefPubMed Solomon LW, Magliocca KR, Cohen C, Müller S (2015) Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum. Oral Surg Oral Med Oral Pathol Oral Radiol 119:213–220CrossRefPubMed
16.
Zurück zum Zitat Chan W, Bullock MJ, Samad AF, Archibald CW, Heathcote JG (2018) NUT carcinoma of the sinonasal tract infiltrating the orbit in a man with birdshot chorioretinitis. Saudi J Ophthalmol 32:62–65CrossRefPubMedPubMedCentral Chan W, Bullock MJ, Samad AF, Archibald CW, Heathcote JG (2018) NUT carcinoma of the sinonasal tract infiltrating the orbit in a man with birdshot chorioretinitis. Saudi J Ophthalmol 32:62–65CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Albrecht T, Harms A, Roessler S, Goeppert B (2019) NUT carcinoma in a nutshell: a diagnosis to be considered more frequently. Pathol Res Pract 215:152347CrossRefPubMed Albrecht T, Harms A, Roessler S, Goeppert B (2019) NUT carcinoma in a nutshell: a diagnosis to be considered more frequently. Pathol Res Pract 215:152347CrossRefPubMed
18.
Zurück zum Zitat Patel SA, Singer B, Shen C, Zanation AM, Yarbrough WG, Weiss J (2021) A case of metastatic NUT carcinoma with prolonged response on gemcitabine and nab-paclitaxel. Clin Case Rep 9:e04616CrossRefPubMedPubMedCentral Patel SA, Singer B, Shen C, Zanation AM, Yarbrough WG, Weiss J (2021) A case of metastatic NUT carcinoma with prolonged response on gemcitabine and nab-paclitaxel. Clin Case Rep 9:e04616CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Crocetta FM, Botti C, Fornaciari M, Castellucci A, Murri D, Santandrea G, Piana S, Ghidini A (2021) Sinonasal NUT carcinoma: delayed diagnosis due to the COVID-19 pandemic and a review of the literature. Head Neck Pathol 15:1409–1414CrossRefPubMedPubMedCentral Crocetta FM, Botti C, Fornaciari M, Castellucci A, Murri D, Santandrea G, Piana S, Ghidini A (2021) Sinonasal NUT carcinoma: delayed diagnosis due to the COVID-19 pandemic and a review of the literature. Head Neck Pathol 15:1409–1414CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Wei X, Teng X, Zhang Y, Cheng M, Chen G (2022) Case report: NUT carcinoma in an elderly woman with unique morphology and immunophenotype highlights a diagnostic pitfall. Transl Cancer Res 11:1850–1860CrossRefPubMedPubMedCentral Wei X, Teng X, Zhang Y, Cheng M, Chen G (2022) Case report: NUT carcinoma in an elderly woman with unique morphology and immunophenotype highlights a diagnostic pitfall. Transl Cancer Res 11:1850–1860CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Wang L, Zhu Z, Wang W, Zha Y, Wang X, Surita A, Liu Y, Lv W (2023) Sinonasal NUT carcinoma: a retrospective case series from a single institution. Front Surg 10:1098704CrossRefPubMedPubMedCentral Wang L, Zhu Z, Wang W, Zha Y, Wang X, Surita A, Liu Y, Lv W (2023) Sinonasal NUT carcinoma: a retrospective case series from a single institution. Front Surg 10:1098704CrossRefPubMedPubMedCentral
Metadaten
Titel
Sinonasal NUT Carcinoma: A Call for Increased Attention to a Vital Clinical Diagnosis
verfasst von
Priti Chatterjee
Anita Nangia
Md Ali Osama
M. C. Sharma
Kartik Kolluru
Sunil Kumar
Publikationsdatum
27.02.2024
Verlag
Springer India
Erschienen in
Indian Journal of Surgical Oncology
Print ISSN: 0975-7651
Elektronische ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-024-01907-z

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