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Clinical Reviews in Allergy & Immunology

Erschienen in:

05.09.2018

Sjögren’s Syndrome and Autoimmune Thyroid Disease: Two Sides of the Same Coin

verfasst von: Juan-Manuel Anaya, Paula Restrepo-Jiménez, Yhojan Rodríguez, Mónica Rodríguez-Jiménez, Yeny Acosta-Ampudia, Diana M. Monsalve, Yovana Pacheco, Carolina Ramírez-Santana, Nicolás Molano-González, Rubén D. Mantilla

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2019

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Abstract

The coexistence of Sjögren’s syndrome (SS) and autoimmune thyroid disease (AITD) has been documented. However, there is no consensus whether this coexistence should be considered as the same nosological condition or as polyautoimmunity. Thus, in this monocentric retrospective study, patients with SS alone (i.e., primary) were compared with patients with SS and AITD. In addition, a discussion of previous studies including those about genetic and environmental factors influencing the development of both conditions is presented. In our series, all patients with AITD had Hashimoto’s thyroiditis (HT). No significant differences in age, gender, age of disease onset, and disease duration were found between the two groups. Lymphadenopathy and urticaria were more frequently registered in patients with SS-HT than in patients with SS alone (p < 0.05). Anti-Ro/SSA antibodies were more frequent in the primary SS group (p = 0.01). SS-HT patients were more likely to report a positive history of smoking (p = 0.03). The clinical expression of SS varies slightly when HT coexists. Although both entities share common physiopathological mechanisms as part of the autoimmune tautology, they are nosologically different and their coexistence should be interpreted as polyautoimmunity. Further studies based on polyautoimmunity would allow establishing a new taxonomy of autoimmune diseases.

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Titel: Sjögren’s Syndrome and Autoimmune Thyroid Disease: Two Sides of the Same Coin
verfasst von: Juan-Manuel Anaya
Paula Restrepo-Jiménez
Yhojan Rodríguez
Mónica Rodríguez-Jiménez
Yeny Acosta-Ampudia
Diana M. Monsalve
Yovana Pacheco
Carolina Ramírez-Santana
Nicolás Molano-González
Rubén D. Mantilla
Publikationsdatum: 05.09.2018
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 3/2019
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-018-8709-9

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Springer Medizin

Sjögren’s Syndrome and Autoimmune Thyroid Disease: Two Sides of the Same Coin

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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