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Erschienen in: Gastric Cancer 2/2015

01.04.2015 | Original Article

Skeletal muscle loss after total gastrectomy, exacerbated by adjuvant chemotherapy

verfasst von: Yusuke Yamaoka, Kazumasa Fujitani, Toshimasa Tsujinaka, Kazuyoshi Yamamoto, Motohiro Hirao, Mitsugu Sekimoto

Erschienen in: Gastric Cancer | Ausgabe 2/2015

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Abstract

Background

Skeletal muscle loss is associated with physical disability, nosocomial infections, postoperative complications, and decreased survival. Preventing the loss of skeletal muscle mass after gastrectomy may lead to improved outcomes. The aims of this study were to assess changes in skeletal muscle mass after total gastrectomy (TG) and to clarify the clinical factors affecting significant loss of skeletal muscle after TG.

Patients and methods

One hundred and two patients undergoing TG for primary gastric cancer underwent abdominal computed tomography before and 1 year after TG to precisely quantify postoperative changes in skeletal muscle and adipose tissue. Univariate and multivariate logistic regression analyses identified clinical factors contributing to significant loss of skeletal muscle after TG.

Results

At 1 year after TG, the mass of both skeletal muscle and adipose tissue was reduced by 6.20 ± 6.80 and 65.8 ± 36.1 % of the preoperative values, respectively, and 26 patients (25.5 %) showed a significant loss of skeletal muscle of more than 10 %. Adjuvant chemotherapy with S-1 for ≥6 months (hazard ratio 26.61, 95 % confidence interval, 3.487–203.1) was identified as the single independent risk factor for a significant loss of skeletal muscle.

Conclusions

Skeletal muscle loss was exacerbated by extended adjuvant chemotherapy after TG. Further research should identify appropriate nutritional interventions for maintaining skeletal muscle mass and leading to improved outcomes.
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Metadaten
Titel
Skeletal muscle loss after total gastrectomy, exacerbated by adjuvant chemotherapy
verfasst von
Yusuke Yamaoka
Kazumasa Fujitani
Toshimasa Tsujinaka
Kazuyoshi Yamamoto
Motohiro Hirao
Mitsugu Sekimoto
Publikationsdatum
01.04.2015
Verlag
Springer Japan
Erschienen in
Gastric Cancer / Ausgabe 2/2015
Print ISSN: 1436-3291
Elektronische ISSN: 1436-3305
DOI
https://doi.org/10.1007/s10120-014-0365-z

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