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Current Dermatology Reports

Erschienen in:

03.09.2018 | Atopic Dermatitis (C Vestergaard, Section Editor)

Skin Barrier Function and Atopic Dermatitis

verfasst von: Pawinee Rerknimitr, Atsushi Otsuka, Chisa Nakashima, Kenji Kabashima

Erschienen in: Current Dermatology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

The purpose of this review was to highlight the importance of the skin barrier in the development of atopic dermatitis (AD).

Recent Findings

Skin barrier function relies on the stratum corneum (SC) and tight junction. These components are deranged in the AD epidermis. Deficiency in filaggrin gives rise to abnormal epidermal integrity. The intercellular lipid composition, ratio, and organization are found to be disturbed. Keratinocyte shedding from the SC is also impaired. Tight junction proteins are reduced and result in sweat leakage into the skin surface.

Summary

Strategies to enhance skin barrier strength will alleviate AD symptoms and may prevent the disease.

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Titel: Skin Barrier Function and Atopic Dermatitis
verfasst von: Pawinee Rerknimitr
Atsushi Otsuka
Chisa Nakashima
Kenji Kabashima
Publikationsdatum: 03.09.2018
Verlag: Springer US
Erschienen in: Current Dermatology Reports / Ausgabe 4/2018
Elektronische ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-018-0232-y

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Skin Barrier Function and Atopic Dermatitis

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