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01.06.2014 | Original Article | Ausgabe 1/2014

Autoimmunity Highlights 1/2014

Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

Zeitschrift:
Autoimmunity Highlights > Ausgabe 1/2014
Autoren:
Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D’Elios, Alberto Bosi, Mario M. D’Elios

Abstract

Objective

To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).

Methods

Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.

Results

Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30+ T-cells are present in the skin of patients with GVHD.

Conclusion

These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.

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