nach oben

Current Treatment Options in Neurology

Erschienen in:

01.11.2018 | Epilepsy (E Waterhouse, Section Editor)

Sleep, Circadian Rhythms, and Epilepsy

verfasst von: Joseph T. Daley, MD, PhD, Jennifer L. DeWolfe, DO

Erschienen in: Current Treatment Options in Neurology | Ausgabe 11/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of review

There is a known interrelationship between sleep and epilepsy. This review highlights the recent findings regarding interactions between sleep and circadian rhythms and the manifestations of epilepsy and surgical treatments for refractory epilepsy.

Recent findings

CLOCK gene expression may be reduced within the epileptogenic focus in patients with refractory epilepsy. Interictal epileptiform discharges during NREM and especially REM sleep may lateralize to the epileptogenic hemisphere. Intracranial video EEG monitoring and EEG from implanted responsive neurostimulator devices confirm scalp video EEG findings of a nocturnal peak for interictal epileptiform discharges. Successful epilepsy surgery may improve sleep macrostructure and quality.

Summary

Sleep outcomes in people with epilepsy undergoing epilepsy surgery and neurostimulator implantation may provide innovative understandings into the associations between sleep and epilepsy. These associations may then provide novel therapeutic options targeting sleep and circadian pathways to improve seizure control and improve the quality of life for patients with this debilitating disorder.

Zach MMaK, R. National and state estimates of the numbers of adults and children with active epilepsy - Unites States, 2015. In: MMWR Morb Mortal Wkly Rep. 2017. 2017.

Leonardi M, Ustun TB. The global burden of epilepsy. Epilepsia. 2002;43(Suppl 6):21–5.CrossRef

Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res. 2015;115:119–25. https://doi.org/10.1016/j.eplepsyres.2015.06.009.CrossRefPubMed

Staniszewska A, Maka A, Religioni U, Olejniczak D. Sleep disturbances among patients with epilepsy. Neuropsychiatr Dis Treat. 2017;13:1797–803. https://doi.org/10.2147/ndt.s136868.CrossRefPubMedPubMedCentral

Nayak CS, Mariyappa N, Majumdar KK, Ravi GS, Prasad PD, Nagappa M, et al. NREM sleep and antiepileptic medications modulate epileptiform activity by altering cortical synchrony. Clinical EEG and neuroscience. 2018;2017:1550059417747436. https://doi.org/10.1177/1550059417747436.CrossRef

Malow BA, Aldrich MS. Localizing value of rapid eye movement sleep in temporal lobe epilepsy. Sleep Med. 2000;1(1):57–60.CrossRef

Busek P, Buskova J, Nevsimalova S. Interictal epileptiform discharges and phasic phenomena of REM sleep. Epileptic disorders : international epilepsy journal with videotape. 2010;12(3):217–21. https://doi.org/10.1684/epd.2010.0319.CrossRef

Okanari K, Baba S, Otsubo H, Widjaja E, Sakuma S, Go CY, et al. Rapid eye movement sleep reveals epileptogenic spikes for resective surgery in children with generalized interictal discharges. Epilepsia. 2015;56(9):1445–53. https://doi.org/10.1111/epi.13081.CrossRefPubMed

Rocamora R, Andrzejak RG, Jimenez-Conde J, Elger CE. Sleep modulation of epileptic activity in mesial and neocortical temporal lobe epilepsy: a study with depth and subdural electrodes. Epilepsy & behavior : E&B. 2013;28(2):185–90. https://doi.org/10.1016/j.yebeh.2013.04.010.CrossRef

10.

Scarlatelli-Lima AV, Sukys-Claudino L, Watanabe N, Guarnieri R, Walz R, Lin K. How do people with drug-resistant mesial temporal lobe epilepsy sleep? A clinical and video-EEG with EOG and submental EMG for sleep staging study. eNeurologicalSci. 2016;4:34–41. https://doi.org/10.1016/j.ensci.2016.06.002.CrossRefPubMedPubMedCentral

11.

Mendez M, Radtke RA. Interactions between sleep and epilepsy. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2001;18(2):106–27.CrossRef

12.

Frauscher B, von Ellenrieder N, Dubeau F, Gotman J. EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans. Epilepsia. 2016;57(6):879–88. https://doi.org/10.1111/epi.13389.CrossRefPubMedPubMedCentral

13.

Campana C, Zubler F, Gibbs S, de Carli F, Proserpio P, Rubino A, et al. Suppression of interictal spikes during phasic rapid eye movement sleep: a quantitative stereo-electroencephalography study. J Sleep Res. 2017;26(5):606–13. https://doi.org/10.1111/jsr.12533.CrossRefPubMed

14.

• Quigg M, Clayburn H, Straume M, Menaker M, Bertram EH 3rd. Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy. Epilepsia. 2000;41(5):502–9 This is an important study that demonstrated that a circadian pattern of seizure occurrence in a rat model of limbic epilepsy.CrossRef

15.

Minecan D, Natarajan A, Marzec M, Malow B. Relationship of epileptic seizures to sleep stage and sleep depth. Sleep. 2002;25(8):899–904.CrossRef

16.

Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy & behavior : E&B. 2009;16(3):461–7. https://doi.org/10.1016/j.yebeh.2009.08.022.CrossRef

17.

Herman ST, Walczak TS, Bazil CW. Distribution of partial seizures during the sleep--wake cycle: differences by seizure onset site. Neurology. 2001;56(11):1453–9.CrossRef

18.

Mirzoev A, Bercovici E, Stewart LS, Cortez MA, Snead OC 3rd, Desrocher M. Circadian profiles of focal epileptic seizures: a need for reappraisal. Seizure. 2012;21(6):412–6. https://doi.org/10.1016/j.seizure.2012.03.014.CrossRefPubMed

19.

Bazil CW, Walczak TS. Effects of sleep and sleep stage on epileptic and nonepileptic seizures. Epilepsia. 1997;38(1):56–62.CrossRef

20.

Durazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology. 2008;70(15):1265–71. https://doi.org/10.1212/01.wnl.0000308938.84918.3f.CrossRefPubMed

21.

Karafin M, St Louis EK, Zimmerman MB, Sparks JD, Granner MA. Bimodal ultradian seizure periodicity in human mesial temporal lobe epilepsy. Seizure. 2010;19(6):347–51. https://doi.org/10.1016/j.seizure.2010.05.005.CrossRefPubMedPubMedCentral

22.

Quigg M. Circadian rhythms: interactions with seizures and epilepsy. Epilepsy Res. 2000;42(1):43–55.CrossRef

23.

•• Spencer DC, Sun FT, Brown SN, Jobst BC, Fountain NB, Wong VS, et al. Circadian and ultradian patterns of epileptiform discharges differ by seizure-onset location during long-term ambulatory intracranial monitoring. Epilepsia. 2016;57(9):1495–502. https://doi.org/10.1111/epi.13455This large study carefully characterizes circadian patterns of interictal epileptiform discharges and timing of seizures based on long-term intracranial data from patients with implanted RNS for refractory epilepsy.CrossRefPubMed

24.

Schapel GJ, Beran RG, Kennaway DL, McLoughney J, Matthews CD. Melatonin response in active epilepsy. Epilepsia. 1995;36(1):75–8.CrossRef

25.

Molina-Carballo A, Acuna-Castroviejo D, Rodriguez-Cabezas T, Munoz-Hoyos A. Effects of febrile and epileptic convulsions on daily variations in plasma melatonin concentration in children. J Pineal Res. 1994;16(1):1–9.CrossRef

26.

Bazil CW, Short D, Crispin D, Zheng W. Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology. 2000;55(11):1746–8.CrossRef

27.

de Lima E, Soares JM Jr, del Carmen Sanabria Garrido Y, Gomes Valente S, Priel MR, Chada Baracat E, et al. Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats. Brain Res. 2005;1043(1–2):24–31. https://doi.org/10.1016/j.brainres.2005.02.027.CrossRefPubMed

28.

Jain S, Besag FM. Does melatonin affect epileptic seizures? Drug Saf. 2013;36(4):207–15. https://doi.org/10.1007/s40264-013-0033-y.CrossRefPubMed

29.

Elkhayat HA, Hassanein SM, Tomoum HY, Abd-Elhamid IA, Asaad T, Elwakkad AS. Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr Neurol. 2010;42(4):249–54. https://doi.org/10.1016/j.pediatrneurol.2009.11.002.CrossRefPubMed

30.

Goldberg-Stern H, Oren H, Peled N, Garty BZ. Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. J Child Neurol. 2012;27(12):1524–8. https://doi.org/10.1177/0883073811435916.CrossRefPubMed

31.

Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet (London, England). 1998;351(9111):1254. https://doi.org/10.1016/s0140-6736(05)79321-1.CrossRef

32.

Cho CH. Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy. Front Cell Neurosci. 2012;6:55. https://doi.org/10.3389/fncel.2012.00055.CrossRefPubMedPubMedCentral

33.

• Li P, Fu X, Smith NA, Ziobro J, Curiel J, Tenga MJ, et al. Loss of CLOCK results in dysfunction of brain circuits underlying focal epilepsy. Neuron. 2017;96(2):387–401 e6. https://doi.org/10.1016/j.neuron.2017.09.044 This study demonstrated evidence that CLOCK gene expression may be reduced within the epileptogenic focus in patients with refractory epilepsy.CrossRefPubMed

34.

Adachi N, Alarcon G, Binnie CD, Elwes RD, Polkey CE, Reynolds EH. Predictive value of interictal epileptiform discharges during non-REM sleep on scalp EEG recordings for the lateralization of epileptogenesis. Epilepsia. 1998;39(6):628–32.CrossRef

35.

Ochi A, Hung R, Weiss S, Widjaja E, To T, Nawa Y, et al. Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. Epilepsia. 2011;52(11):1986–94. https://doi.org/10.1111/j.1528-1167.2011.03198.x.CrossRefPubMed

36.

Legros B, Bazil CW. Effects of antiepileptic drugs on sleep architecture: a pilot study. Sleep Med. 2003;4(1):51–5.CrossRef

37.

• Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 2013;55(1):26–37. https://doi.org/10.1111/epi.12478This is an extensive review which critically evaluates the literature evaulating the effects on AEDs on objective sleep measures.CrossRefPubMed

38.

van Golde EG, Gutter T, de Weerd AW. Sleep disturbances in people with epilepsy; prevalence, impact and treatment. Sleep Med Rev. 2011;15(6):357–68. https://doi.org/10.1016/j.smrv.2011.01.002.CrossRefPubMed

39.

Maganti R, Hausman N, Koehn M, Sandok E, Glurich I, Mukesh BN. Excessive daytime sleepiness and sleep complaints among children with epilepsy. Epilepsy & behavior : E&B. 2006;8(1):272–7. https://doi.org/10.1016/j.yebeh.2005.11.002.CrossRef

40.

Giorelli AS, Passos P, Carnaval T, Gomes Mda M. Excessive daytime sleepiness and epilepsy: a systematic review. Epilepsy research and treatment 2013;2013:629469. doi:https://doi.org/10.1155/2013/629469, 9.CrossRef

41.

Gutter T, Brouwer OF, de Weerd AW. Subjective sleep disturbances in children with partial epilepsy and their effects on quality of life. Epilepsy & behavior : E&B. 2013;28(3):481–8. https://doi.org/10.1016/j.yebeh.2013.06.022.CrossRef

42.

Kaleyias J, Cruz M, Goraya JS, Valencia I, Khurana DS, Legido A, et al. Spectrum of polysomnographic abnormalities in children with epilepsy. Pediatr Neurol. 2008;39(3):170–6. https://doi.org/10.1016/j.pediatrneurol.2008.06.002.CrossRefPubMed

43.

• Carrion MJ, Nunes ML, Martinez JV, Portuguez MW, da Costa JC. Evaluation of sleep quality in patients with refractory seizures who undergo epilepsy surgery. Epilepsy & behavior : E&B. 2010;17(1):120–3. https://doi.org/10.1016/j.yebeh.2009.11.008This is prospective study evaluating sleep quality in patients with refractory mesial temporal lobe epilepsy before and after temporal lobectomy.CrossRef

44.

• Serafini A, Kuate C, Gelisse P, Velizarova R, Gigli GL, Coubes P, et al. Sleep before and after temporal lobe epilepsy surgery. Seizure. 2012;21(4):260–5. https://doi.org/10.1016/j.seizure.2012.01.007This study prospectively evaluated objective sleep parameters before and up to 2 years after temporal lobectomy.CrossRefPubMed

45.

•• Zanzmera P, Shukla G, Gupta A, Goyal V, Srivastava A, Garg A, et al. Effect of successful epilepsy surgery on subjective and objective sleep parameters--a prospective study. Sleep Med. 2013;14(4):333–8. https://doi.org/10.1016/j.sleep.2012.11.017 This is the first study to prospectively measure objective and subjective parameters before and after temporal lobectomy.CrossRefPubMed

46.

Nobili L, Francione S, Mai R, Cardinale F, Castana L, Tassi L, et al. Surgical treatment of drug-resistant nocturnal frontal lobe epilepsy. Brain : a Journal of Neurology. 2007;130(Pt 2):561–73. https://doi.org/10.1093/brain/awl322.CrossRef

47.

McCormick L, Nielsen T, Ptito M, Ptito A, Villemure JG, Vera C, et al. Sleep in right hemispherectomized patients: evidence of electrophysiological compensation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 2000;111(8):1488–97.CrossRef

48.

Foldvary-Schaefer N, Stephenson L, Bingaman W. Resolution of obstructive sleep apnea with epilepsy surgery? Expanding the relationship between sleep and epilepsy. Epilepsia. 2008;49(8):1457–9. https://doi.org/10.1111/j.1528-1167.2008.01677.x.CrossRefPubMed

49.

Romero-Osorio O, Gil-Tamayo S, Narino D, Rosselli D. Changes in sleep patterns after vagus nerve stimulation, deep brain stimulation or epilepsy surgery: systematic review of the literature. Seizure. 2018;56:4–8. https://doi.org/10.1016/j.seizure.2018.01.022.CrossRefPubMed

50.

Malow BA, Edwards J, Marzec M, Sagher O, Ross D, Fromes G. Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients. Neurology. 2001;57(5):879–84.CrossRef

51.

Rizzo P, Beelke M, De Carli F, Canovaro P, Nobili L, Robert A, et al. Chronic vagus nerve stimulation improves alertness and reduces rapid eye movement sleep in patients affected by refractory epilepsy. Sleep. 2003;26(5):607–11.CrossRef

52.

Galli R, Bonanni E, Pizzanelli C, Maestri M, Lutzemberger L, Giorgi FS, et al. Daytime vigilance and quality of life in epileptic patients treated with vagus nerve stimulation. Epilepsy & Behavior : E&B. 2003;4(2):185–91.CrossRef

53.

Hallbook T, Lundgren J, Kohler S, Blennow G, Stromblad LG, Rosen I. Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy. European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society. 2005;9(6):399–407. https://doi.org/10.1016/j.ejpn.2005.08.004.CrossRef

54.

St Louis EK, Faber K. Reversible sleep-related stridor during vagus nerve stimulation. Epileptic Disorders : International Epilepsy Journal With Videotape. 2010;12(1):76–80. https://doi.org/10.1684/epd.2010.0294.CrossRef

55.

Gschliesser V, Hogl B, Frauscher B, Brandauer E, Poewe W, Luef G. Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy. Seizure. 2009;18(5):339–42. https://doi.org/10.1016/j.seizure.2008.12.003.CrossRefPubMed

56.

Malow BA, Edwards J, Marzec M, Sagher O, Fromes G. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology. 2000;55(10):1450–4.CrossRef

57.

Marzec M, Edwards J, Sagher O, Fromes G, Malow BA. Effects of vagus nerve stimulation on sleep-related breathing in epilepsy patients. Epilepsia. 2003;44(7):930–5.CrossRef

58.

Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010;51(5):899–908. https://doi.org/10.1111/j.1528-1167.2010.02536.x.CrossRef

59.

Voges BR, Schmitt FC, Hamel W, House PM, Kluge C, Moll CK, et al. Deep brain stimulation of anterior nucleus thalami disrupts sleep in epilepsy patients. Epilepsia. 2015;56(8):e99–e103. https://doi.org/10.1111/epi.13045.CrossRefPubMed

60.

Kinnear KM, Warner NM, Haltiner AM, Doherty MJ. Continuous monitoring devices and seizure patterns by glucose, time and lateralized seizure onset. Epilepsy & Behavior Case Reports. 2018;10:65–70. https://doi.org/10.1016/j.ebcr.2018.03.001.CrossRef

Titel: Sleep, Circadian Rhythms, and Epilepsy
verfasst von: Joseph T. Daley, MD, PhD
Jennifer L. DeWolfe, DO
Publikationsdatum: 01.11.2018
Verlag: Springer US
Erschienen in: Current Treatment Options in Neurology / Ausgabe 11/2018
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI: https://doi.org/10.1007/s11940-018-0534-1

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

16.04.2024 | Maligne primäre ZNS-Tumoren | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Sleep, Circadian Rhythms, and Epilepsy

Abstract

Purpose of review

Recent findings

Summary

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Simple Kortisontherapie stoppt primär progrediente Aphasie

Impostor-Syndrom häufig bei Hyperhidrose zu finden

Update Neurologie

Springer Medizin

Abstract

Purpose of review

Recent findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2018

Novel Systemic Treatments for Brain Metastases From Lung Cancer

Sleep Abnormalities in Wilson’s Disease

Managing Antiepileptic Medication in Dialysis Patients

Stem Cell Therapy in Cerebrovascular Disease

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Simple Kortisontherapie stoppt primär progrediente Aphasie

Impostor-Syndrom häufig bei Hyperhidrose zu finden

Update Neurologie