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Inflammation Research

Erschienen in:

18.08.2020 | Original Research Paper

Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production

verfasst von: Lu Liu, Li Zhang, Longjiang Li, Mengting Chen, Zhe Wang, Yi Shen, Jiayi Huang, Ling Tang

Erschienen in: Inflammation Research | Ausgabe 11/2020

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Abstract

Objective

Sleep loss is common in patients with liver injury, but the effects of sleep deprivation (SD) on liver injury remain unclear. In the present study, the potential effects of SD on acute liver injury and the underlying mechanisms have been investigated.

Methods

The sleep of male BALB/c mice has been deprived by using a modified multiple platform water bath for 3 days and acute liver injury was induced by intraperitoneal injection of lipopolysaccharide (LPS) and d-galactosamine (D-Gal). The degree of liver injury was detected by aminotransferase determination, histopathology and survival rate analysis. Inflammatory response and melatonin (MT) were measured by enzyme-linked immunosorbent assay (ELISA). In addition, hepatocyte apoptosis was determined by caspase activity measurement and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay.

Results

We observed that SD increased plasma aminotransferases, TUNEL-positive hepatocytes, histological abnormalities and mortality rates in mice with LPS/D-Gal treatment. SD also promoted LPS/D-Gal-induced production of TNF-α and upregulated hepatic caspase-8, caspase-9, and caspase-3 activities in LPS/D-Gal-exposed mice. In addition, SD significantly decreased MT contents in plasma of mice with acute liver injury, but supplementation with MT reversed these SD-promoted changes.

Conclusion

Our data suggested that SD exacerbated LPS/D-Gal-induced liver injury via decreasing melatonin production.

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Titel: Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production
verfasst von: Lu Liu
Li Zhang
Longjiang Li
Mengting Chen
Zhe Wang
Yi Shen
Jiayi Huang
Ling Tang
Publikationsdatum: 18.08.2020
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 11/2020
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-020-01393-3

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Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production

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Objective

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Conclusion

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