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Erschienen in: International Ophthalmology 1/2020

20.08.2019 | Original Paper

Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event

verfasst von: Recai Türkoğlu, Gülçin Benbir, Selen Özyurt, Erdil Arsoy, Ece Akbayır, Selin Turan, Derya Karadeniz, Vuslat Yılmaz, Mehmet Gencer, Erdem Tüzün

Erschienen in: International Ophthalmology | Ausgabe 1/2020

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Abstract

Purpose

Multiple sclerosis (MS) patients whose first demyelinating event is optic neuritis have been claimed to display a milder disease course and reduced physical disability. Our aim was to investigate the impact of the clinical features of the first clinical episode on cognitive disability and sleep dysfunction in MS.

Methods

A total of 26 (10 with optic neuritis as the first clinical event) MS patients were recruited. A comprehensive sleep study was performed, and a panel of tests were administered to examine cognitive and motor performance. Serum levels of sleep-related mediators orexin-A and melatonin were measured by enzyme-linked immunosorbent assay. Subjective sleep quality was evaluated by Pittsburgh sleep quality test, and daytime excessive sleepiness was tested by Epworth sleepiness scale.

Results

MS patients with the first clinical episode of optic neuritis and patients with at least one optic neuritis attack exhibited increased daytime sleepiness, higher sleep efficiency and NREM duration and lower total wake time. Patients with a history of optic neuritis obtained more favorable scores in neuropsychological tests measuring executive functions and complex attention as compared to those who had never experienced optic neuritis. Melatonin and orexin-A levels were lower in patients with optic neuritis onset. The higher no. of optic neuritis attacks was associated with reduced wake time and higher symbol digit modalities test scores.

Conclusions

Having a history of optic neuritis is associated with improved sleep quality and executive functions but increased daytime sleepiness. Reduction of orexin-A and melatonin levels might be one of the underlying mechanisms.
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Metadaten
Titel
Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event
verfasst von
Recai Türkoğlu
Gülçin Benbir
Selen Özyurt
Erdil Arsoy
Ece Akbayır
Selin Turan
Derya Karadeniz
Vuslat Yılmaz
Mehmet Gencer
Erdem Tüzün
Publikationsdatum
20.08.2019
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 1/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01157-x

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