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Current Sleep Medicine Reports

Erschienen in:

01.06.2019 | Sleep and Neurological Conditions (A Avidan, Section Editor)

Sleep Disturbances in Patients with Disorders of the Nerve and Muscle Diseases

verfasst von: Jorge L. Morales-Estrella, Loutfi S. Aboussouan

Erschienen in: Current Sleep Medicine Reports | Ausgabe 2/2019

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Abstract

Purpose of Review

Recognize sleep disorders associated with neuromuscular diseases.

Recent Findings

Neuromuscular diseases can be associated with various sleep disorders. Diaphragmatic weakness, bulbar dysfunction, pharyngeal neuropathy, and central neurodegeneration cause sleep-disordered breathing. Spinal cord hyperexcitability, loss of inhibitory descending pathways, and neuropathy promote restless legs syndrome. Reduced cerebrospinal fluid (CSF) hypocretin, central dysfunction of sleep regulation, and degeneration of GABAergic intracortical circuits may contribute to central hypersomnia. Dysfunction of the nigrostriatal dopaminergic system, associated with neurodegenerative diseases and certain neuromuscular disorders, may be a common pathophysiologic mechanism responsible for the loss of rapid eye movement (REM) sleep muscle atonia and REM sleep behavior disorder (RBD).

Summary

Different neuromuscular disorder may be more susceptible to specific sleep disturbances. A low threshold needs to be maintained for the diagnosis and treatment of sleep disorders in neuromuscular diseases, due to their high prevalence, lack of symptom specificity, and presence even in minimally symptomatic patients. However, loss of REM atonia may be protective against sleep-disordered breathing. There are reasonable pathophysiologic mechanisms such as respiratory muscle weakness, upper airway obstruction, and central dysfunction that explain the link between sleep disorders and neuromuscular diseases

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Titel: Sleep Disturbances in Patients with Disorders of the Nerve and Muscle Diseases
verfasst von: Jorge L. Morales-Estrella
Loutfi S. Aboussouan
Publikationsdatum: 01.06.2019
Verlag: Springer International Publishing
Erschienen in: Current Sleep Medicine Reports / Ausgabe 2/2019
Elektronische ISSN: 2198-6401
DOI: https://doi.org/10.1007/s40675-019-00140-3

Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment

Sleep and Neurological Conditions (A Avidan, Section Editor)

Sleep Disordered Breathing at High Altitude in Adults and Its Interaction with Cardiovascular Homeostasis

Sleep and Sleep Apnea at the Extremes (D Gozal, Section Editor)

Polysomnography in Preterm Infants with Bronchopulmonary Dysplasia for Monitoring Sleep-Disordered Breathing and Pulmonary Reserve

Sleep and Sleep Apnea at the Extremes (D Gozal, Section Editor)

The Impact of Altitude on Sleep-Related Breathing Disorders in Infants and Children

Sleep and Sleep Apnea at the Extremes (D Gozal, Section Editor)

The Interface Between Sleep and Epilepsy

Sleep and Neurological Conditions (A Avidan, Section Editor)

Oropharyngeal Exercises for Treatment of Pediatric Obstructive Sleep-Disordered Breathing

Sleep and Otolaryngology (H Gouveris, Section Editor)

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Springer Medizin

Sleep Disturbances in Patients with Disorders of the Nerve and Muscle Diseases

Abstract

Purpose of Review

Recent Findings

Summary

Weitere Artikel der Ausgabe 2/2019

Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment

Sleep Disordered Breathing at High Altitude in Adults and Its Interaction with Cardiovascular Homeostasis

Polysomnography in Preterm Infants with Bronchopulmonary Dysplasia for Monitoring Sleep-Disordered Breathing and Pulmonary Reserve

The Impact of Altitude on Sleep-Related Breathing Disorders in Infants and Children

The Interface Between Sleep and Epilepsy

Oropharyngeal Exercises for Treatment of Pediatric Obstructive Sleep-Disordered Breathing

Kompaktes Leitlinien-Wissen Neurologie (Link öffnet in neuem Fenster)

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Suizidassistenz erhöht Suizidzahlen: Aktuelle Ergebnisse der geplanten S3-Leitlinie

Kaum Vorteile durch intraarterielle Lyse während Thrombektomie

Nasenstimulation lindert chronische Migräne

Update Neurologie

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Purpose of Review

Recent Findings

Summary

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