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Obesity Surgery
Erschienen in: Obesity Surgery 7/2016

06.10.2015 | Original Contributions

Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats

verfasst von: Rafael Moncada, Amaia Rodríguez, Sara Becerril, Leire Méndez-Giménez, Víctor Valentí, Beatriz Ramírez, Javier A. Cienfuegos, Secundino Fernández, Victoria Catalán, Javier Gómez-Ambrosi, Gema Frühbeck

Erschienen in: Obesity Surgery | Ausgabe 7/2016

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Abstract

Background

Aging and obesity are two conditions associated with increased risk of cardiovascular disease. Our aim was to analyze whether an advanced age affects the beneficial effects of sleeve gastrectomy on weight loss and blood pressure in an experimental model of diet-induced obesity (DIO).

Methods

Young (6-month-old) and old (18-month-old) male Wistar DIO rats (n = 101) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary interventions (pair-fed to the amount of food eaten by sleeve gastrectomized animals). Systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure values and heart rate (HR) were recorded in conscious, resting animals by non-invasive tail-cuff plethysmography before and 4 weeks after surgical or dietary interventions.

Results

Aging was associated with higher (P < 0.05) body weight and subcutaneous and perirenal fat mass as well as mild cardiac hypertrophy. Sleeve gastrectomy induced a reduction in body weight, whole-body adiposity, and serum total ghrelin in both young and old DIO rats. The younger group achieved a higher excess weight loss than the older group (164 ± 60 vs. 82 ± 17 %, P < 0.05). A significant (P < 0.05) decrease in insulin resistance, SBP, DBP, MBP, and HR without changes in heart weight was observed after sleeve gastrectomy independently of age.

Conclusion

Our results provide evidence for the effectiveness of sleeve gastrectomy without increased operative risk in body weight and blood pressure reduction even in aged animals via endocrine changes that go beyond the mere caloric restriction.
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Metadaten
Titel
Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats
verfasst von
Rafael Moncada
Amaia Rodríguez
Sara Becerril
Leire Méndez-Giménez
Víctor Valentí
Beatriz Ramírez
Javier A. Cienfuegos
Secundino Fernández
Victoria Catalán
Javier Gómez-Ambrosi
Gema Frühbeck
Publikationsdatum
06.10.2015
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 7/2016
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-015-1919-9

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