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Obesity Surgery
Erschienen in: Obesity Surgery 7/2019

21.03.2019 | Original Contributions

Sleeve Gastrectomy Rescuing the Altered Functional Connectivity of Lateral but Not Medial Hypothalamus in Subjects with Obesity

verfasst von: Panlong Li, Han Shan, Binbin Nie, Hua Liu, Guanglong Dong, Yulin Guo, Jin Du, Hongkai Gao, Lin Ma, Demin Li, Baoci Shan

Erschienen in: Obesity Surgery | Ausgabe 7/2019

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Abstract

Background

Lateral and medial hypothalamus (LH and MH) play important roles in energy balance. Changed hypothalamic function has been found in subjects with obesity. However, the effect of bariatric surgery on the function of the two sub-regions has been poorly investigated.

Methods

Thirty-eight subjects with obesity and 34 age- and sex-matched normal-weight controls were included. Seventeen of the 38 subjects underwent laparoscopic sleeve gastrectomy. Functional magnetic resonance imaging data and metabolic parameters were collected to investigate functional connectivity networks of the two hypothalamic sub-regions as well as the influence of sleeve gastrectomy on the two networks in subjects with obesity.

Results

Compared to normal-weight controls, pre-surgical subjects had increased functional connectivity (FC) in the reward region (putamen) within the LH network, and increased FC in somatosensory cortical area (insula), as well as decreased FC in the cognitive control regions (prefrontal regions) within the MH network. After the surgery, post-surgical FC of the putamen within the LH network changed towards the patterns found in the control group. Furthermore, the changes in fasting glucose before and after the surgery were associated with the changes in FC of the putamen within the LH network.

Conclusions

The FC within the LH and MH networks were changed in subjects with obesity. Part of these altered FC was rescued after the surgery.
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Metadaten
Titel
Sleeve Gastrectomy Rescuing the Altered Functional Connectivity of Lateral but Not Medial Hypothalamus in Subjects with Obesity
verfasst von
Panlong Li
Han Shan
Binbin Nie
Hua Liu
Guanglong Dong
Yulin Guo
Jin Du
Hongkai Gao
Lin Ma
Demin Li
Baoci Shan
Publikationsdatum
21.03.2019
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 7/2019
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-019-03822-7

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