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08.06.2024 | BRIEF REPORT

Small blue round cell tumor with focal epithelial differentiation harboring a novel YAP1::LEUTX fusion with poor prognosis

verfasst von: Xu-Xi Yang, Feng Gao, Ru Ding, Jia Wei, Xiao-Mei Zhu, Qi‐Xing Gong

Erschienen in: Virchows Archiv | Ausgabe 2/2024

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While the small blue round cell tumor encompasses a group of malignancies with varying origins of differentiation, recent molecular genetic advancements have enabled a more precise definition and revolutionized diagnosis of these tumors. Herein, we report a unique case of small blue round cell tumor exhibiting focal epithelial differentiation and harboring a novel YAP1::LEUTX fusion gene, which does not fit in any known pathological categories. After a thorough investigation of the tumor’s morphology and immunophenotype, along with a comprehensive literature review, we propose a provisional category of LEUTX-rearranged tumors, which has distinct clinicopathological features. …

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Titel: Small blue round cell tumor with focal epithelial differentiation harboring a novel YAP1::LEUTX fusion with poor prognosis
verfasst von: Xu-Xi Yang
Feng Gao
Ru Ding
Jia Wei
Xiao-Mei Zhu
Qi‐Xing Gong
Publikationsdatum: 08.06.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 2/2024
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-024-03839-z

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