The authors declare that they have no competing interests.
TMM reviewed the data and drafted the manuscript. RM reviewed the clinical data and revised the manuscript. BB and DW were the pathologists on the case and reviewed and reported the morphology and immunohistochemistry. DLS was the treating physician, drafted and reviewed the manuscript. All authors read and approved the final manuscript.
Small lymphocytic lymphoma is a relatively rare B-cell non-Hodgkin lymphoma that is considered to be the tissue equivalent of the much more common entity chronic lymphocytic leukemia. Cutaneous manifestations of small lymphocytic lymphoma are infrequent and the literature regarding them sparse. We describe here a case of a patient with a history of small lymphocytic lymphoma who developed perniosis-like features of the digits.
An 86-year old male patient with previously diagnosed small lymphocytic lymphoma developed painful erythematous swelling of the periungual area of his fingers and toes. This was associated with a dense dermal infiltration of CD5-positive B-lymphoid cells consistent with his low-grade B-cell lymphoma. Although partially refractory to local radiotherapy, the painful swelling of the fingers and toes resolved fully following systemic therapy with chlorambucil and rituximab.
This unusual cutaneous manifestation of a lymphoma and the favourable response to systemic therapy may be instructive for the management of other patients who develop similar perniosis-like features.
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- Small lymphocytic lymphoma with florid perniosis-like features: a case report
Taylor M. Morris
David L. Saltman
- BioMed Central
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