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29.03.2024 | Original Article

Smart Use of Skin Biopsy Punch in Treating Keloids: A Single-Center Retrospective Study

verfasst von: Yixin Li, Jingyi Dong, Liuhong Liu, Kai Huang, Dingheng Zhu, Wu Zhu, Shuang Zhao, Renliang He

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 15/2024

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Abstract

Background

Treatment of scarring has long been a problem due to high incidence and recurrence. Despite many existing treatment therapies, the efficacy remains unstable.

Objectives

To determine the efficacy and safety of skin biopsy punch in combination with corticosteroid injection (BPCI) in treating keloids.

Approach

This was a retrospective study. In total, 16 patients with keloids received BPCI. Changes in scar appearance, accompanied symptoms, and Vancouver Scar Scale (VSS) were analyzed. Patient satisfaction, VAS scores, and adverse effects were also evaluated.

Results

Scar appearance, accompanied symptoms, and VSS scores improved significantly after the treatment. The total effective rate was 93.75% at an 18-month follow-up on average. The mean reduction rate of VSS score was 58.44% (p < 0.0001), especially in height and pliability (84.44% and 78.19%, p < 0.0001). The recurrence rate in this study was 12.5% (n = 2) at an 18-month follow-up on average. Mild adverse effects of pain, pruritus, hypopigmentation, and telangiectasia were recorded.

Conclusions

This study demonstrated BPCI might be an effective and safe therapy in keloids with a low long-time recurrence rate and well tolerance for patients.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
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Literatur
1.
Zurück zum Zitat Wolfram D, Tzankov A, Pulzl P et al (2009) Hypertrophic scars and keloids—a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35(2):171–181PubMedCrossRef Wolfram D, Tzankov A, Pulzl P et al (2009) Hypertrophic scars and keloids—a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35(2):171–181PubMedCrossRef
2.
Zurück zum Zitat Gauglitz GG, Korting HC, Pavicic T et al (2011) Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 17(1–2):113–125PubMedCrossRef Gauglitz GG, Korting HC, Pavicic T et al (2011) Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 17(1–2):113–125PubMedCrossRef
3.
4.
Zurück zum Zitat Sen CK, Gordillo GM, Roy S et al (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17(6):763–771PubMedPubMedCentralCrossRef Sen CK, Gordillo GM, Roy S et al (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17(6):763–771PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Berman B, Bieley HC (1996) Adjunct therapies to surgical management of keloids. Dermatol Surg 22(2):126–130PubMedCrossRef Berman B, Bieley HC (1996) Adjunct therapies to surgical management of keloids. Dermatol Surg 22(2):126–130PubMedCrossRef
6.
Zurück zum Zitat Gold MH, McGuire M, Mustoe TA et al (2014) Updated international clinical recommendations on scar management: part 2–algorithms for scar prevention and treatment. Dermatol Surg 40(8):825–831PubMed Gold MH, McGuire M, Mustoe TA et al (2014) Updated international clinical recommendations on scar management: part 2–algorithms for scar prevention and treatment. Dermatol Surg 40(8):825–831PubMed
7.
Zurück zum Zitat Morelli Coppola M, Salzillo R, Segreto F, Persichetti P (2018) Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol 11:387–396PubMedPubMedCentralCrossRef Morelli Coppola M, Salzillo R, Segreto F, Persichetti P (2018) Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol 11:387–396PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Leventhal D, Furr M, Reiter D (2006) Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch Facial Plast Surg 8(6):362–368PubMedCrossRef Leventhal D, Furr M, Reiter D (2006) Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch Facial Plast Surg 8(6):362–368PubMedCrossRef
9.
Zurück zum Zitat Kural MH, Billiar KL (2016) Myofibroblast persistence with real-time changes in boundary stiffness. Acta Biomater 32:223–230PubMedCrossRef Kural MH, Billiar KL (2016) Myofibroblast persistence with real-time changes in boundary stiffness. Acta Biomater 32:223–230PubMedCrossRef
10.
Zurück zum Zitat Ledon JA, Savas J, Franca K et al (2013) Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg 39(12):1745–1757PubMedCrossRef Ledon JA, Savas J, Franca K et al (2013) Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg 39(12):1745–1757PubMedCrossRef
11.
Zurück zum Zitat Wilson AM (2013) Eradication of keloids: Surgical excision followed by a single injection of intralesional 5-fluorouracil and botulinum toxin. Can J Plast Surg 21(2):87–91PubMedPubMedCentralCrossRef Wilson AM (2013) Eradication of keloids: Surgical excision followed by a single injection of intralesional 5-fluorouracil and botulinum toxin. Can J Plast Surg 21(2):87–91PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Lee SY, Park J (2015) Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence. Ann Dermatol 27(1):53–58PubMedPubMedCentralCrossRef Lee SY, Park J (2015) Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence. Ann Dermatol 27(1):53–58PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Lee YI, Kim J, Yang CE et al (2019) Combined therapeutic strategies for keloid treatment. Dermatol Surg 45(6):802–810PubMedCrossRef Lee YI, Kim J, Yang CE et al (2019) Combined therapeutic strategies for keloid treatment. Dermatol Surg 45(6):802–810PubMedCrossRef
14.
Zurück zum Zitat Bijlard E, Timman R, Verduijn GM et al (2018) Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: randomised controlled trials. J Plast Reconstr Aesthet Surg 71(6):847–856PubMedCrossRef Bijlard E, Timman R, Verduijn GM et al (2018) Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: randomised controlled trials. J Plast Reconstr Aesthet Surg 71(6):847–856PubMedCrossRef
15.
Zurück zum Zitat Butler PD, Longaker MT, Yang GP (2008) Current progress in keloid research and treatment. J Am Coll Surg 206(4):731–741PubMedCrossRef Butler PD, Longaker MT, Yang GP (2008) Current progress in keloid research and treatment. J Am Coll Surg 206(4):731–741PubMedCrossRef
16.
Zurück zum Zitat Wang H, Zhao W, Xu M et al (2021) Treatment of keloids by surgical excision combined with 5-fluorouracil and betamethasone injection. Dermatol Surg 47(5):740–741PubMedCrossRef Wang H, Zhao W, Xu M et al (2021) Treatment of keloids by surgical excision combined with 5-fluorouracil and betamethasone injection. Dermatol Surg 47(5):740–741PubMedCrossRef
17.
18.
Zurück zum Zitat Sohrabi C, Goutos I (2020) The use of botulinum toxin in keloid scar management: a literature review. Scars Burn Heal 6:2059513120926628PubMedPubMedCentral Sohrabi C, Goutos I (2020) The use of botulinum toxin in keloid scar management: a literature review. Scars Burn Heal 6:2059513120926628PubMedPubMedCentral
19.
Zurück zum Zitat Wang P, Gu L, Bi H et al (2021) Comparing the Efficacy and Safety of Intralesional verapamil with Intralesional triamcinolone Acetonide in treatment of hypertrophic scars and keloids: a meta-analysis of randomized controlled trials. Aesthet Surg J 41(6):np567–np575PubMedCrossRef Wang P, Gu L, Bi H et al (2021) Comparing the Efficacy and Safety of Intralesional verapamil with Intralesional triamcinolone Acetonide in treatment of hypertrophic scars and keloids: a meta-analysis of randomized controlled trials. Aesthet Surg J 41(6):np567–np575PubMedCrossRef
20.
Zurück zum Zitat Hussein Ali E, Adnan SS (2019) Effect of collagenase ointment versus moist exposed burn ointment on healing of full-thickness burns in mice by removing of necrotic tissue. Dermatol Ther 32(1):e12769PubMedCrossRef Hussein Ali E, Adnan SS (2019) Effect of collagenase ointment versus moist exposed burn ointment on healing of full-thickness burns in mice by removing of necrotic tissue. Dermatol Ther 32(1):e12769PubMedCrossRef
21.
Zurück zum Zitat Baryza MJ, Baryza GA (1995) The Vancouver scar scale: an administration tool and its interrater reliability. J Burn Care Rehabil 16(5):535–538PubMedCrossRef Baryza MJ, Baryza GA (1995) The Vancouver scar scale: an administration tool and its interrater reliability. J Burn Care Rehabil 16(5):535–538PubMedCrossRef
22.
Zurück zum Zitat Reed MD, Van Nostran W (2014) Assessing pain intensity with the visual analog scale: a plea for uniformity. J Clin Pharmacol 54(3):241–244PubMedCrossRef Reed MD, Van Nostran W (2014) Assessing pain intensity with the visual analog scale: a plea for uniformity. J Clin Pharmacol 54(3):241–244PubMedCrossRef
23.
Zurück zum Zitat Ogawa R (2022) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg 149(1):79e–94ePubMedCrossRef Ogawa R (2022) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg 149(1):79e–94ePubMedCrossRef
24.
Zurück zum Zitat Gurtner GC, Dauskardt RH, Wong VW et al (2011) Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann Surg 254(2):217–225PubMedCrossRef Gurtner GC, Dauskardt RH, Wong VW et al (2011) Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann Surg 254(2):217–225PubMedCrossRef
25.
Zurück zum Zitat Rustad KC, Wong VW, Gurtner GC (2013) The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation. Differentiation 86(3):87–91PubMedCrossRef Rustad KC, Wong VW, Gurtner GC (2013) The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation. Differentiation 86(3):87–91PubMedCrossRef
26.
Zurück zum Zitat Artz M, Trimaille A, Labouche A et al (2022) Outcomes associated with combination shaving and cryosurgery treatment in patients with keloid scars. JAMA Dermatol 158(8):956–958PubMedPubMedCentralCrossRef Artz M, Trimaille A, Labouche A et al (2022) Outcomes associated with combination shaving and cryosurgery treatment in patients with keloid scars. JAMA Dermatol 158(8):956–958PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Azzam EZ, Omar SS (2018) Treatment of auricular keloids by triple combination therapy: surgical excision, platelet-rich plasma, and cryosurgery. J Cosmet Dermatol 17(3):502–510PubMedCrossRef Azzam EZ, Omar SS (2018) Treatment of auricular keloids by triple combination therapy: surgical excision, platelet-rich plasma, and cryosurgery. J Cosmet Dermatol 17(3):502–510PubMedCrossRef
28.
Zurück zum Zitat van Leeuwen MCE, van der Wal MBA, Bulstra AJ et al (2015) Intralesional cryotherapy for treatment of keloid scars: a prospective study. Plast Reconstr Surg 135(2):580–589PubMedCrossRef van Leeuwen MCE, van der Wal MBA, Bulstra AJ et al (2015) Intralesional cryotherapy for treatment of keloid scars: a prospective study. Plast Reconstr Surg 135(2):580–589PubMedCrossRef
29.
Zurück zum Zitat Harn HI, Ogawa R, Hsu CK et al (2019) The tension biology of wound healing. Exp Dermatol 28(4):464–471PubMedCrossRef Harn HI, Ogawa R, Hsu CK et al (2019) The tension biology of wound healing. Exp Dermatol 28(4):464–471PubMedCrossRef
30.
Zurück zum Zitat Burd A, Huang L (2005) Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg 116(7):150e–157ePubMedCrossRef Burd A, Huang L (2005) Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg 116(7):150e–157ePubMedCrossRef
31.
Zurück zum Zitat Choi YJ, Lee YH, Lee HJ et al (2020) Auricular keloid management in Asian skin: clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection. J Cosmet Dermatol 19(11):3041–3047PubMedCrossRef Choi YJ, Lee YH, Lee HJ et al (2020) Auricular keloid management in Asian skin: clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection. J Cosmet Dermatol 19(11):3041–3047PubMedCrossRef
32.
Zurück zum Zitat Ogawa R, Akaishi S, Dohi T et al (2015) Analysis of the surgical treatments of 63 keloids on the cartilaginous part of the auricle: effectiveness of the core excision method. Plast Reconstr Surg 135(3):868–875PubMedCrossRef Ogawa R, Akaishi S, Dohi T et al (2015) Analysis of the surgical treatments of 63 keloids on the cartilaginous part of the auricle: effectiveness of the core excision method. Plast Reconstr Surg 135(3):868–875PubMedCrossRef
33.
Zurück zum Zitat McCoy BJ, Diegelmann RF, Cohen IK (1980) In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med 163(2):216–222PubMedCrossRef McCoy BJ, Diegelmann RF, Cohen IK (1980) In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med 163(2):216–222PubMedCrossRef
34.
Zurück zum Zitat Tan S, Khumalo N, Bayat A (2019) Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies. Front Immunol 10:1810PubMedPubMedCentralCrossRef Tan S, Khumalo N, Bayat A (2019) Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies. Front Immunol 10:1810PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Al-Attar A, Mess S, Thomassen JM et al (2006) Keloid pathogenesis and treatment. Plast Reconstr Surg 117(1):286–300PubMedCrossRef Al-Attar A, Mess S, Thomassen JM et al (2006) Keloid pathogenesis and treatment. Plast Reconstr Surg 117(1):286–300PubMedCrossRef
36.
Zurück zum Zitat Mankowski P, Kanevsky J, Tomlinson J et al (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78(4):403–411PubMedCrossRef Mankowski P, Kanevsky J, Tomlinson J et al (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78(4):403–411PubMedCrossRef
37.
Zurück zum Zitat Son Y, Phillips EON, Price KM et al (2020) Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: an in vitro and in vivo study. J Am Acad Dermatol 83(5):1304–1314PubMedCrossRef Son Y, Phillips EON, Price KM et al (2020) Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: an in vitro and in vivo study. J Am Acad Dermatol 83(5):1304–1314PubMedCrossRef
38.
Zurück zum Zitat Bijlard E, Steltenpool S, Niessen FB (2015) Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol 95(7):778–782PubMed Bijlard E, Steltenpool S, Niessen FB (2015) Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol 95(7):778–782PubMed
39.
Zurück zum Zitat Erlendsson AM, Anderson RR, Manstein D et al (2014) Developing technology: ablative fractional lasers enhance topical drug delivery. Dermatol Surg 40(Suppl 12):S142–S146PubMedCrossRef Erlendsson AM, Anderson RR, Manstein D et al (2014) Developing technology: ablative fractional lasers enhance topical drug delivery. Dermatol Surg 40(Suppl 12):S142–S146PubMedCrossRef
40.
Zurück zum Zitat Dhurat R, Daruwalla SB, Sharma A (2019) Fractionated de-volumizing Keloid tissue—the “pop” method—a novel technique to facilitate administration of intralesional corticosteroid in difficult keloids. J Am Acad Dermatol 88(2):e75–e77PubMedCrossRef Dhurat R, Daruwalla SB, Sharma A (2019) Fractionated de-volumizing Keloid tissue—the “pop” method—a novel technique to facilitate administration of intralesional corticosteroid in difficult keloids. J Am Acad Dermatol 88(2):e75–e77PubMedCrossRef
41.
Zurück zum Zitat Wang P, Wang Q, Yang X et al (2023) Targeting the glycolytic enzyme pgk1 to inhibit the Warburg effect: a new strategy for keloid therapy. Plast Reconstr Surg 151(6):970e–980ePubMed Wang P, Wang Q, Yang X et al (2023) Targeting the glycolytic enzyme pgk1 to inhibit the Warburg effect: a new strategy for keloid therapy. Plast Reconstr Surg 151(6):970e–980ePubMed
Metadaten
Titel
Smart Use of Skin Biopsy Punch in Treating Keloids: A Single-Center Retrospective Study
verfasst von
Yixin Li
Jingyi Dong
Liuhong Liu
Kai Huang
Dingheng Zhu
Wu Zhu
Shuang Zhao
Renliang He
Publikationsdatum
29.03.2024
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 15/2024
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-024-04000-6

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