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01.12.2014 | Original paper | Ausgabe 12/2014

Cancer Causes & Control 12/2014

Smoking, alcohol, diabetes, obesity, socioeconomic status, and the risk of colorectal cancer in a population-based case–control study

Zeitschrift:
Cancer Causes & Control > Ausgabe 12/2014
Autoren:
Terry Boyle, Lin Fritschi, Seyed Mehdi Tabatabaei, Kathrin Ringwald, Jane S. Heyworth
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10552-014-0470-7) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Although previous research has identified factors that may determine willingness to participate in research, relatively few studies have attempted to quantify the impact non-participation may have on exposure–disease associations. The aims of this study were to (a) investigate the associations between smoking, alcohol, diabetes, obesity, and socioeconomic status and the risk of colorectal cancer in a case–control study (59.7 and 47.2 % response fractions among cases and controls, respectively); and (b) perform sensitivity analyses to examine the possible influence of non-participation.

Methods

Logistic regression was used to estimate the exposure–disease associations. We then investigated the associations between various demographic and health factors and the likelihood that an individual would participate in the case–control study and then performed two sensitivity analyses (sampling weights and multiple imputation) to examine whether non-participation bias may have influenced the exposure–disease associations.

Results

The exposures alcohol, smoking, and diabetes were associated with an increased risk of colorectal cancer. We found some differences between cases and controls when examining the factors associated with the participation in the study, and in the sensitivity analyses, the exposure–disease associations were slightly attenuated when compared with those from the original analysis.

Conclusion

Non-participation may have biased the risk estimates away from the null, but generally not enough to change the conclusions of the study.

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Zusatzmaterial
Supplementary material 1 (DOC 75 kb)
10552_2014_470_MOESM1_ESM.doc
Literatur
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