Introduction
Methods
Eligibility criteria
Search strategy
Selection criteria
Data extraction and analysis
Statistical methods
Quality assessment and risk of bias across studies
Results
Eligible studies
Description of studies
Study | Years | Study design | Population | Age | Male (%) | Sample size | Country | Follow-up (year) |
---|---|---|---|---|---|---|---|---|
Ali [14] | 2013 | Prospective cohort study | Using our hospital’s Get with the Guidelines-Stroke (GWTGStroke) registry, we analyzed patients consecutively admitted with AIS | 59.6 ± 13.8 | 60.0 | 4305 | USA | 0.0 |
Ali [15] | 2015 | Retrospective cohort study | Using our hospital’s Get with the Guidelines-Stroke (GWTGStroke) registry, we analyzed patients consecutively admitted with AIS | 70.3 ± 14.8 | 48.5 | 899,295 | Canada | 0.0 |
Bejot [16] | 2014 | Prospective cohort study | All patients diagnosed with a first-ever IS occurring between 1st January 2006 and 31st December 2011 were prospectively identified among residents of the city of Dijon, France (2007 census: 151,543 inhabitants) from the Dijon Stroke Registry | 63.3 ± 16.7 | 65.2 | 973 | France | 0.0 |
Chung [17] | 2016 | Retrospective cohort study | We retrieved data from TVGHSR on patients who were consecutively admitted and registered between January 1, 2012 and February 28, 2014 | 74.9 ± 8.9 | 75.0 | 60 | Taiwan | 1.0 |
Edjoc [9] | 2013 | Prospective cohort study | The Registry of the Canadian Stroke Network (RCSN) contains data for over 50,000 strokes in Canada. 17 participating sites include all Ontario acute care institutions. A cohort of 20,523 patients was selected for this study from the RCSN | 61.8 ± 13.17 | 52.1 | 20,523 | Canada | 1.0 |
Fekete [10] | 2014 | Retrospective cohort study | The database of the Mures Uzhgorod Debrecen study was analyzed. Altogether 1049 patients are recorded in the database (603 men) | − | − | 716 | Hungary | 1.0 |
Glymour [18] | 2008 | Prospective cohort study | The Health and Retirement Study (HRS) is a national, longitudinal survey of U.S. adults aged ≥ 50 years and their spouses. 10–12 Enrollments occurred in 1992, 1993, 1998, and 2004, staggered by birth cohort | 61 | − | 16,225 | USA | 9.1 |
Hou [19] | 2017 | Case–control study | A dataset from the China Nationwide Retrospective Mortality Survey, conducted from 1989 through 1991, was used. This survey included 1,136,686 all-cause deaths of subjects aged 30 years or older during the years 1986–1988 from 24 urban areas and 79 rural counties randomly chosen from over 2000 counties in China | 64.9 ± 10.4 | 66.7 | 32,410 | China | 0.0 |
Hou [20] | 2017a | Prospective cohort study | First-ever ischemic stroke patients hospitalized in the Department of Neurology, West China Hospital, Sichuan University were eligible for this study. A total of 720 first-ever ischemic stroke patients were recruited during 2010–2014 | 61.5 ± 12.4 | 100.0 | 378 | China | 3.0 |
Kim [5] | 2012 | Prospective cohort study | 1589 cases of first-ever and recurrent stroke were recruited between 1996 and 1999 from a defined geographical region in North East Melbourne. Both hospital and nonhospital cases were included | − | 48.3 | 1230 | Australia | 10.0 |
Kumagai [6] | 2013 | Prospective cohort study | Patients were enrolled in this study from participants in the Edaravone and Argatroban Stroke Therapy (EAST) for Acute Ischemic Stroke study. The study began in August 2004 and ended in May 2008 | 71.9 ± 9.7 | 59.8 | 660 | Japan | 0.2 |
Lee [21] | 2015 | Retrospective cohort study | Subjects were consecutive patients with first-ever ischemic stroke and without previous functional disability (modified Rankin Scale [mRS] score > 1) who were admitted to Hallym University Medical Center within 7 days of symptom onset between October 2007 and July 2012. The data were populated from the Hallym Stroke Registry, a prospective hospital-based stroke database | 65.3 ± 13.5 | 57.4 | 1113 | Korea | 0.2 |
Ovbiagele [22] | 2005 | Prospective cohort study | Data from Trials 1 and 2 of the National Institute of Neurological Disorders and Stroke (NINDS) Tissue Plasminogen Activator (tPA) Study were analyzed | 64.19 | 57.0 | 305 | USA | 1.0 |
Ovbiagele [7] | 2006 | Prospective cohort study | We abstracted data from the IMAGES trial database for this analysis. We identified 2386 subjects with acute ischemic stroke | − | 53.5 | 2386 | USA | 0.2 |
Tong [23] | 2016 | Prospective cohort study | TIMS-China was a national prospective stroke registry of thrombolytic therapy with intravenous alteplase for AIS patients in 67 major stroke centers in China. Between May 2007 and April 2012, 1440 AIS patients treated with IVT were registered in the TIMS-China project | − | 60.8 | 1118 | China | 0.2 |
von Martial [24] | 2018 | Prospective cohort study | This study was based on the Bernese stroke center database, a systematic prospective registry of consecutive patients with ischemic stroke treated at the Stroke Center of University Hospital of Berne, Switzerland. we analyzed all stroke patients who underwent EVT between January 2005 and December 2015. A total of 935 patients were eligible for this study | 68 ± 13.9 | 54.3 | 935 | Switzerland | 0.2 |
Weng [12] | 2011 | Retrospective cohort study | Patient data were collected from SRICHS. There were a total of 3843 ischemic stroke patients in the SRICHS in 2009. We included 2740 patients | 63.9 ± 12.5 | 62.7 | 2650 | Taiwan | 0.0 |
Zhang [25] | 2017 | Retrospective cohort study | We retrospectively reviewed the prospectively maintained stroke registry of a single medical center (Xuanwu Hospital) comprising 1910 non-cardiogenic ischemic stroke patients consecutively discharged from January 2013 to October 2014 | 58.68 ± 11.60 | 95.4 | 1792 | China | 1.0 |
Total 18 studies | 987,074 |
Cohort studies | |||
---|---|---|---|
Reference | Selection | Comparability | Outcome |
Ali 2013 [14] | ☆☆☆☆ | ☆☆ | ☆ |
Ali 2015 [15] | ☆☆☆ | ☆☆ | ☆ |
Bejot 2014 [16] | ☆☆☆☆ | ☆☆ | ☆ |
Chung 2016 [17] | ☆☆☆ | ☆☆ | ☆☆☆ |
Edjoc 2013 [9] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
Fekete 2014 [10] | ☆☆☆ | ☆☆ | ☆☆☆ |
Glymour 2008 [18] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
Hou 2017a [20] | ☆☆☆☆ | ☆☆ | ☆☆ |
Kim 2012 [5] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
Kumagai 2013 [6] | ☆☆☆☆ | ☆☆ | ☆☆ |
Lee 2015 [21] | ☆☆☆ | ☆☆ | ☆☆☆ |
Ovbiagele 2005 [22] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
Ovbiagele 2006 [7] | ☆☆☆☆ | ☆☆ | ☆☆ |
Tong2016 [23] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
von Martial 2018 [24] | ☆☆☆☆ | ☆☆ | ☆☆☆ |
Weng 2011 [12] | ☆☆☆ | ☆☆ | ☆ |
Zhang 2017 [25] | ☆☆☆ | ☆☆ | ☆☆☆ |
Case–control studies | |||
---|---|---|---|
Reference | Selection | Comparability | Exposure |
Hou 2017 [19] | ☆☆☆☆ | ☆☆ | ☆☆☆ |