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08.02.2016 | Psychiatry and Preclinical Psychiatric Studies - Review Article

SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond

verfasst von: Renata Basso Cupertino, Djenifer B. Kappel, Cibele Edom Bandeira, Jaqueline Bohrer Schuch, Bruna Santos da Silva, Diana Müller, Claiton Henrique Dotto Bau, Nina Roth Mota

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2016

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Abstract

Multiple biological processes throughout development require intracellular vesicular trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors) complex plays a major role. The core proteins forming the SNARE complex are SNAP-25 (synaptosomal-associated protein 25), VAMP (vesicle-associated membrane protein) and Syntaxins, besides its regulatory proteins, such as Synaptotagmin. Genes encoding these proteins (SNAP25, VAMP1, VAMP2, STX1A, SYT1 and SYT2) have been studied in relation to psychiatric disorders susceptibility. Here, we review physiological aspects of SNARE complex and genetic association results reported for attention deficit hyperactivity disorder, both in children and adults, autism spectrum disorders, major depressive disorder, bipolar disorder and schizophrenia. Moreover, we included findings from expression, pharmacogenetics and animal model studies regarding these clinical phenotypes. The overall scenario depicted here suggests that the SNARE complex may exert distinct roles throughout development, with age-specific effects of genetic variants in psychiatric disorders. Such perspective should be considered in future studies regarding SNARE complex genes.

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Titel: SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond
verfasst von: Renata Basso Cupertino
Djenifer B. Kappel
Cibele Edom Bandeira
Jaqueline Bohrer Schuch
Bruna Santos da Silva
Diana Müller
Claiton Henrique Dotto Bau
Nina Roth Mota
Publikationsdatum: 08.02.2016
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 8/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1514-9

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