Sneeze and pop: a ruptured varicocele; analysis of literature, guided by a well-documented case-report

We carried out a systematic literature search for PubMed, EMBASE, and Cochrane Library, using Medical Subject Headings indexes, keyword searchers and publication types until May 2017. Additionally, the reference lists of included articles/case reports were also examined for potential studies. There was no language restriction, as long as all relevant info was present (in the abstract), and the abstract was in English. The following keywords were used in the search: varicocele rupture, or spermatic cord hematoma, or hematocele spermatic cord. The terms were separately searched or connected by the Boolean operators “AND” and “OR”. We identified in our search 31 case reports. Differentiation could be made based on etiology into three major causes, i.e. idiopathic, spontaneous hematomas (18×) [3‐20], (direct) traumatic (6×) [21‐26], as a result of a coagulation disorder (4×) [27‐30]. No abstract or not all necessary information was available in seven case reports. Since this article is on idiopathic, spontaneous hematoma’s, only these case reports will be discussed. Results of the literature search are shown in Table 1.

Idiopathic, spontaneous hematomas are thought to be the result of sudden increase of abdominal pressure transmitting to a varicocele. It’s arbitrary whether abdominal trauma can lead to increased abdominal pressure, resulting in a ruptured varicocele [8]. A study of Shafik & Bedeir (1980). showed that patients with a left-sided varicocele develop an increased venous pressure during a Valsalva manoeuvre [31]. Various structures, (i.e. vein of the normal pampiniform plexus, a single varix or false aneurysm of the spermatic artery), have been identified as bleeding source. However, in the majority of cases the bleeding source at surgery cannot be identified [10].

Average age of presentation was 31 (±18) years, with the overall majority of males in their 20s at presentation. This makes distinction between possible testicular torsion, or malignancy difficult, since both affect mostly males between 15 and 35 [32]. Accurate differential diagnosis can possibly be facilitated by taking the patients history with emphasis on possible triggering events. Preceding events to the spontaneous scrotal hematoma in literature could all be narrowed down to increased abdominal pressure. Existing literature describes various activities preceding a spontaneous scrotal hematoma, reviewed in Table 1. Examples are pressure during defecation [4, 7, 9, 11], sexual intercourse [13], blunt abdominal trauma [5, 8, 14], heavy lifting [6], stretching in tight pants [15] or after fighter-pilot centrifuge training [19]. Another patient had a spontaneous hematoma after playing the saxophone [10]. After an inguinal hernia correction at 18 years, doctors had discouraged him from playing ever again. Although strict compliance of this advice, 35 years later he could not resist the urge to play. He presented himself at the ER an hour later. To our knowledge, a scrotal hematoma resulting from sneezing has never been described. When an unknown swelling is present in the scrotum, physicians should include the question whether any activities increasing abdominal pressure, or any strenuous activities, had preceded the swelling, when taking patients history.

Reported clinical presentation of patients with a spontaneous ruptured varicocele is acute pain (83%), and acute (inguinal) scrotal swelling (100%), which could also be difficult to distinguish from testicular torsion, appendix testis torsion, or malignancy. Important to note is that patients with testicular cancer commonly present with a painless mass. Just 10 % of patients present with acute symptoms such as pain [33], so when pain is present malignancy becomes more unlikely. Ecchymosis can sometimes be seen after a few days (33%), but is rarely reported on. Unfortunately, none of the case reports reported on the cremaster reflex. With the exception of three cases, all spontaneous hematoma’s (83%) were found on the left side, conform the higher incidence of left sided varicocele [2]. Varicoceles are more common on the left side due to a longer left testicular vein and congenital incompetence of the valves of the left testicular veins [34]. Other causes are entering of the left testicular vein on the left renal vein at a right angle, arching of the left testicular vein over the left testicular artery thereby compressing it (in some men), compression of the left testicular vein by the descending colon, or compression of the left renal vein between the superior mesenteric artery and the abdominal aorta (nutcracker effect) [35]. The question arises whether the right-sided cases therefore should be categorized as traumatic, even though their described etiology was different.

Diagnosing a cause of acute scrotal pain and swelling can be difficult, and as stated the differential diagnosis should include conditions such as testicular torsion, malignancy, epididymo-orchitis, or (incarcerated) inguinal hernia [6, 14].

Blood analyses and coagulation tests could be performed to exclude any bleeding disorders. In one case, symptoms mimicked an epididymo-orchitis, due to leucocytosis [3]. No ultrasound was performed. The delay in treatment resulted in ischaemia due to obstruction, necrosis of the testis, and eventually orchiectomy.

CUD is the imaging modality of choice in evaluating patients who present with acute scrotal pain [35], especially in cases where testicular blood flow is of the essence. Gray-scale images are nonspecific for detecting testicular torsion. A distinction should be made between intra-testicular and extra-testicular hematomas, since intra-testicular hematomas can result in testicular infection or necrosis in 40% of patients without exploration [35]. A hematoma on CUD is shown as a heterogeneous, hypo-echogenic, non-vascular mass, which can be mistaken with a malignancy. CT-Abdomen or MRI can be used to diagnose arteriovenous malformations.

Imaging of the scrotum was performed in all but four cases [4, 10, 12, 16], where CUD was the mostly used modality. In all four cases without any imaging, exploration was performed, with one resulting in an orchiectomy due to suspected tumour [16].

Surgical exploration is indicated when diagnosis is uncertain, or when a testicular torsion or ischaemia cannot be excluded, and orchiectomy can be performed when malignancy is highly expected, (or partial or a intraoperative biopsy). However, physicians should be cautious for unnecessary orchiectomy. When performing exploration, an inguinal approach is recommended, if malignancy is possible, to avoid scrotal violation. Additional arguments for exploration are possible future complications, i.e. testicular ischaemia due to obstruction of the hematoma on the funiculus [14], possible hematoma infection, or no regression in size of the hematoma. Eventually, microscopic ligation/embolisation of the varicocele can be performed [7, 9].

Overall, exploration was performed in ten patients (56%), indicating the lack of knowledge about idiopathic spontaneous hematomas of the scrotum. Direct exploration at presentation was performed in eight patients (44%). Reasons of direct exploration were uncertain diagnosis (63%) [4, 8, 12, 16, 18], suspected incarcerated inguinal hernia [10], or persisting pain [14, 20]. In the two patients, delayed exploration was performed due to no improvement of symptoms, or ischemia of the left testis [3, 6]. In 25% of patients, direct exploration resulted in orchiectomy [16, 18].

Present varicocele is usually diagnosed with imaging or surgical exploration after the forming of the hematoma. Besides the case report of Gordon et al. 1993 [8], this is the only known case report where the patient had a known untreated varicocele. However, there have been case reports without signs of a varicocele at exploration [4]. In eight case reports, a present varicocele was reported, after either CUD or during exploration. It is not known if special attention was given to possible varicoceles during US examination in all cases.

In general, the scrotal hematoma is considered self-limiting and should be treated conservatively. Symptoms can be treated with NSAID’s, and RICE (rest, ice, compression and elevation of the scrotum).

In our patient, the hematoma increased in size up to 3 months post-event. Only after microscopic inguinal varicocelectomy the size of the hematoma started to decrease. It is unsure whether this is a result of the treatment or time. After 15 months, the hematoma was dissolved completely. It is important to inform the patient of the possible duration of completely reabsorption to avoid anxiety and unnecessary follow-up diagnostics.

Avoiding increased abdominal pressure for patients with known varicocele, to avoid spontaneous ruptures does not seem indicated. The scarcity of case reports, as a complication of a condition present in about 15% of males, shows its rarity. Recurrent hematomas have never been described.