Skip to main content
Erschienen in: AIDS and Behavior 7/2017

11.11.2016 | Original Paper

Social Support and the Mediating Roles of Alcohol Use and Adherence Self-Efficacy on Antiretroviral Therapy (ART) Adherence Among ART Recipients in Gauteng, South Africa

verfasst von: Connie T. Kekwaletswe, Esmé Jordaan, Sebenzile Nkosi, Neo K. Morojele

Erschienen in: AIDS and Behavior | Ausgabe 7/2017

Einloggen, um Zugang zu erhalten

Abstract

We sought to (a) replicate and (b) extend (via the addition of alcohol use) Cha et al.’s cross-sectional multi-component model of ART adherence on the relationship between social support, depression, self-efficacy beliefs, and antiretroviral therapy (ART) adherence, among HIV patients in Tshwane, South Africa. Using purposive sampling, 304 male and female ART recipients were recruited. ART adherence was assessed using three manifest indicators: total adherence ratio, the CASE adherence index and 1-month adherence measure. Data were analysed using structural equation modeling. In our replicated model, social support had both direct and indirect relationships with ART adherence, and inclusion of alcohol use improved prediction of ART adherence. Direct and indirect effects of alcohol use on ART adherence emerged: adherence self-efficacy beliefs partially mediated the latter path. Findings highlight the importance of integrating into ART promotion interventions, the reduction of alcohol use, provision of social support, and enhancement of adherence self-efficacy beliefs.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat UNAIDS. UNAIDS report on the global AIDS epidemic 2013. Geneva: Author; 2013. UNAIDS. UNAIDS report on the global AIDS epidemic 2013. Geneva: Author; 2013.
2.
Zurück zum Zitat Larson E, Bendavid E, Tuoane-Nkhasi M, Mbengashe T, Goldman T, Wilson M, et al. Population-level associations between antiretroviral therapy scale-up and all-cause mortality in South Africa. Int J STD AIDS. 2013;25(9):636–42.CrossRefPubMed Larson E, Bendavid E, Tuoane-Nkhasi M, Mbengashe T, Goldman T, Wilson M, et al. Population-level associations between antiretroviral therapy scale-up and all-cause mortality in South Africa. Int J STD AIDS. 2013;25(9):636–42.CrossRefPubMed
4.
Zurück zum Zitat WHO. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. Geneva: Author; 2015. WHO. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. Geneva: Author; 2015.
5.
Zurück zum Zitat Mills EJ, Nachega JB, Bangsberg DR, Singh S, Rachlis B, Wu P, et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006;3(11):e438.CrossRefPubMedPubMedCentral Mills EJ, Nachega JB, Bangsberg DR, Singh S, Rachlis B, Wu P, et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006;3(11):e438.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Amberbir A, Woldemichael K, Getachew S, Girma B, Deribe K. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Public Health. 2008;8(265). Amberbir A, Woldemichael K, Getachew S, Girma B, Deribe K. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Public Health. 2008;8(265).
7.
Zurück zum Zitat Carrieri P, Cailleton V, Le Moing V, Spire B, Dellamonica P, Bouvet E, et al. The dynamic of adherence to highly active antiretroviral therapy: results from the French National APROCO cohort. J Acquir Immune Defic Syndr. 2001;28:232–9.CrossRefPubMed Carrieri P, Cailleton V, Le Moing V, Spire B, Dellamonica P, Bouvet E, et al. The dynamic of adherence to highly active antiretroviral therapy: results from the French National APROCO cohort. J Acquir Immune Defic Syndr. 2001;28:232–9.CrossRefPubMed
8.
Zurück zum Zitat Grierson J, Koelmeyer RL, Smith A, Pitts M. Adherence to antiretroviral therapy: factors independently associated with reported difficulty taking antiretroviral therapy in a national sample of HIV-positive Australians. HIV Med. 2011;12(9):562–9.CrossRefPubMed Grierson J, Koelmeyer RL, Smith A, Pitts M. Adherence to antiretroviral therapy: factors independently associated with reported difficulty taking antiretroviral therapy in a national sample of HIV-positive Australians. HIV Med. 2011;12(9):562–9.CrossRefPubMed
9.
Zurück zum Zitat Byakika-Tusiime J, Crane J, Oyugi JH, Ragland K, Kawuma A, Musoke P, et al. Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS Behav. 2009;13:82–91.CrossRefPubMed Byakika-Tusiime J, Crane J, Oyugi JH, Ragland K, Kawuma A, Musoke P, et al. Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS Behav. 2009;13:82–91.CrossRefPubMed
10.
Zurück zum Zitat Genberg BL, Lee Y, Rogers WH, Wilson IB. Four types of barriers to adherence of antiretroviral therapy are associated with decreased adherence over time. AIDS Behav. 2015;19(1):85–92.CrossRefPubMedPubMedCentral Genberg BL, Lee Y, Rogers WH, Wilson IB. Four types of barriers to adherence of antiretroviral therapy are associated with decreased adherence over time. AIDS Behav. 2015;19(1):85–92.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Azar MM, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend. 2010;112:178–93.CrossRefPubMedPubMedCentral Azar MM, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend. 2010;112:178–93.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Binford MC, Kahana SY, Altice FL. A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs. Curr HIV/AIDS Rep. 2012;9:287–312.CrossRefPubMed Binford MC, Kahana SY, Altice FL. A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs. Curr HIV/AIDS Rep. 2012;9:287–312.CrossRefPubMed
13.
Zurück zum Zitat Hendershot CS, Stoner SA, Pantalone DW, Simoni JM. Alcohol use and antiretroviral adherence: review and meta-analysis. J Acquir Immune Defic Syndr. 2009;52(2):180–202.CrossRefPubMedPubMedCentral Hendershot CS, Stoner SA, Pantalone DW, Simoni JM. Alcohol use and antiretroviral adherence: review and meta-analysis. J Acquir Immune Defic Syndr. 2009;52(2):180–202.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Nakimuli-Mpungu E, Bass JK, Alexandre P, Mills EJ, Musisi S, Ram M, et al. Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: a systematic review. AIDS Behav. 2012;16(8):2101–18.CrossRefPubMed Nakimuli-Mpungu E, Bass JK, Alexandre P, Mills EJ, Musisi S, Ram M, et al. Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: a systematic review. AIDS Behav. 2012;16(8):2101–18.CrossRefPubMed
15.
Zurück zum Zitat Vagenas P, Azar MM, Copenhaver MM, Springer SA, Molina PE, Altice FL. The impact of alcohol use and related disorders on the HIV continuum of care: a systematic review—alcohol and the HIV continuum of care. Curr HIV/AIDS Rep. 2015; 12(4):421–36. Vagenas P, Azar MM, Copenhaver MM, Springer SA, Molina PE, Altice FL. The impact of alcohol use and related disorders on the HIV continuum of care: a systematic review—alcohol and the HIV continuum of care. Curr HIV/AIDS Rep. 2015; 12(4):421–36.
16.
Zurück zum Zitat WHO. Global status report on alcohol and health 2014. Geneva: Author; 2014. WHO. Global status report on alcohol and health 2014. Geneva: Author; 2014.
17.
Zurück zum Zitat Parry CDH, Kekwaletswe C, Shuper PA, Nkosi S, Myers BJ, Morojele N. Heavy alcohol use in patients on highly active antiretroviral therapy: what responses are needed? S Afr Med J. 2016;106(6):567–8.CrossRef Parry CDH, Kekwaletswe C, Shuper PA, Nkosi S, Myers BJ, Morojele N. Heavy alcohol use in patients on highly active antiretroviral therapy: what responses are needed? S Afr Med J. 2016;106(6):567–8.CrossRef
18.
Zurück zum Zitat Huis In ‘t Veld D, Pengpid S, Colebunders R, Skaal L, Peltzer K. High-risk alcohol use and associated socio-demographic, health, and psychosocial factors in patients with HIV infection in three primary health care clinics in South Africa. Int J STD AIDS. 2016; July 21 (Epub ahead of print). Huis In ‘t Veld D, Pengpid S, Colebunders R, Skaal L, Peltzer K. High-risk alcohol use and associated socio-demographic, health, and psychosocial factors in patients with HIV infection in three primary health care clinics in South Africa. Int J STD AIDS. 2016; July 21 (Epub ahead of print).
19.
Zurück zum Zitat Cha E, Erlen JA, Kim KH, Sereika SM, Caruthers D. Mediating roles of medication-taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: a questionnaire survey. Int J Nurs Stud. 2008;45(8):1175–84.CrossRefPubMed Cha E, Erlen JA, Kim KH, Sereika SM, Caruthers D. Mediating roles of medication-taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: a questionnaire survey. Int J Nurs Stud. 2008;45(8):1175–84.CrossRefPubMed
20.
Zurück zum Zitat DiIorio C, McCarty F, DePadilla L, Resnicow K, Holstad MM, Yeager K, et al. Adherence to antoretroviral medication regimens: a test of a psychosocial model. AIDS Behav. 2009;13(1):10–22.CrossRefPubMed DiIorio C, McCarty F, DePadilla L, Resnicow K, Holstad MM, Yeager K, et al. Adherence to antoretroviral medication regimens: a test of a psychosocial model. AIDS Behav. 2009;13(1):10–22.CrossRefPubMed
21.
Zurück zum Zitat Simoni JM, Frick PA, Huang B. A longitudinal evaluation of a social support model of medication adherence among HIV-positive men and women on antiretroviral therapy. Health Psychol. 2006;25(1):74–81.CrossRefPubMedPubMedCentral Simoni JM, Frick PA, Huang B. A longitudinal evaluation of a social support model of medication adherence among HIV-positive men and women on antiretroviral therapy. Health Psychol. 2006;25(1):74–81.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Woodward EN, Pantalone DW. The role of social support and negative affect in medication adherence for HIV-infected men who have sex with men. J Assoc Nurses AIDS Care. 2012;23(5): 388-96. Woodward EN, Pantalone DW. The role of social support and negative affect in medication adherence for HIV-infected men who have sex with men. J Assoc Nurses AIDS Care. 2012;23(5): 388-96.
23.
Zurück zum Zitat Ware NC, Idoko J, Kaaya S, Biraro IA, Wyatt MA, Oche Agbaji O, et al. Explaining adherence success in sub-Saharan Africa: an ethnographic study. PLoS Med. 2009;6(1):e1000011.CrossRefPubMedCentral Ware NC, Idoko J, Kaaya S, Biraro IA, Wyatt MA, Oche Agbaji O, et al. Explaining adherence success in sub-Saharan Africa: an ethnographic study. PLoS Med. 2009;6(1):e1000011.CrossRefPubMedCentral
24.
Zurück zum Zitat O’Laughlin KN, Wyatt MA, Kaaya S, Bangsberg DR, Ware NC. How treatment partners help: social analysis of an African adherence support intervention. AIDS Behav. 2012;16(5):1308–15.CrossRefPubMed O’Laughlin KN, Wyatt MA, Kaaya S, Bangsberg DR, Ware NC. How treatment partners help: social analysis of an African adherence support intervention. AIDS Behav. 2012;16(5):1308–15.CrossRefPubMed
25.
26.
Zurück zum Zitat Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401.CrossRef Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401.CrossRef
27.
Zurück zum Zitat Hedayati SS, Bosworth HB, Kuchibhatla M, Kimmel PL, Szczech LA. The predictive value of self report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int. 2006;69:1662–8.CrossRefPubMed Hedayati SS, Bosworth HB, Kuchibhatla M, Kimmel PL, Szczech LA. The predictive value of self report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int. 2006;69:1662–8.CrossRefPubMed
28.
Zurück zum Zitat Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the alcohol use disorders screening test (AUDIT). WHO collaborative project on early detection of persons with harmful alcohol consumption. II. Addiction. 1993;88:791–804. Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the alcohol use disorders screening test (AUDIT). WHO collaborative project on early detection of persons with harmful alcohol consumption. II. Addiction. 1993;88:791–804.
29.
Zurück zum Zitat Johnson MO, Neilands TB, Dilworth S, Morin SF, Remien RH, Chesney MA. The role of self-efficacy in HIV treatment adherence: validation of the HIV treatment adherence self-efficacy scale (HIV-ASES). J Behav Med. 2007;30(5):359–70.CrossRefPubMedPubMedCentral Johnson MO, Neilands TB, Dilworth S, Morin SF, Remien RH, Chesney MA. The role of self-efficacy in HIV treatment adherence: validation of the HIV treatment adherence self-efficacy scale (HIV-ASES). J Behav Med. 2007;30(5):359–70.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient care committee & adherence working group of the outcomes Committee of the adult AIDS clinical trials group (AACTG). AIDS Care. 2000;12:255–66.CrossRefPubMed Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient care committee & adherence working group of the outcomes Committee of the adult AIDS clinical trials group (AACTG). AIDS Care. 2000;12:255–66.CrossRefPubMed
31.
Zurück zum Zitat Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA. Optimizing measurement of adherence of self-reported adherence with ACTG adherence questionnaire: a cross-protocol analysis. J Acquir Immune Defic Syndr. 1997;46(4):402–9.CrossRef Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA. Optimizing measurement of adherence of self-reported adherence with ACTG adherence questionnaire: a cross-protocol analysis. J Acquir Immune Defic Syndr. 1997;46(4):402–9.CrossRef
32.
Zurück zum Zitat Mannheimer SB, Mukherjee R, Hirschhorn LR, Dougherty J, Celano SA, Ciccarone D, et al. The case adherence index: a novel method for measuring adherence to antiretroviral therapy. AIDS Care. 2006;18(7):853–61.CrossRefPubMedPubMedCentral Mannheimer SB, Mukherjee R, Hirschhorn LR, Dougherty J, Celano SA, Ciccarone D, et al. The case adherence index: a novel method for measuring adherence to antiretroviral therapy. AIDS Care. 2006;18(7):853–61.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008;12:86–94.CrossRefPubMed Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008;12:86–94.CrossRefPubMed
34.
Zurück zum Zitat Muthén LK, Muthén BO. Mplus User’s Guide. Los Angeles: Muthén & Muthén; 1998–2014. Muthén LK, Muthén BO. Mplus User’s Guide. Los Angeles: Muthén & Muthén; 1998–2014.
35.
Zurück zum Zitat Hu LT, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equ Modeling. 1999;6:1–55.CrossRef Hu LT, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equ Modeling. 1999;6:1–55.CrossRef
36.
Zurück zum Zitat Tucker LR, Lewis C. A reliability coefficient for maximum likelihood factor analysis. Psychometrika. 1973;38(1):1–10.CrossRef Tucker LR, Lewis C. A reliability coefficient for maximum likelihood factor analysis. Psychometrika. 1973;38(1):1–10.CrossRef
37.
Zurück zum Zitat Byrne BM. Structural equation modeling with LISREL, PRELIS and SIMPLIS: basic concepts, applications and programming. Mahwah: Lawrence Erlbaum Associates; 1998. Byrne BM. Structural equation modeling with LISREL, PRELIS and SIMPLIS: basic concepts, applications and programming. Mahwah: Lawrence Erlbaum Associates; 1998.
38.
Zurück zum Zitat Cai L, Maydeu-Olivares A, Coffman DL, Thissen D. Limited information goodness of fit testing of item response theory models for sparse 2p tables. Br J Math Stat Psychol. 2006;59:173–94.CrossRefPubMed Cai L, Maydeu-Olivares A, Coffman DL, Thissen D. Limited information goodness of fit testing of item response theory models for sparse 2p tables. Br J Math Stat Psychol. 2006;59:173–94.CrossRefPubMed
39.
Zurück zum Zitat Kline RB. Principles and practice of structural equation modeling. New York: Guilford Press; 1998. Kline RB. Principles and practice of structural equation modeling. New York: Guilford Press; 1998.
40.
Zurück zum Zitat Comrey AL, Lee HB. A first course in factor analysis. Hillsdale: Erlbaum; 1992. Comrey AL, Lee HB. A first course in factor analysis. Hillsdale: Erlbaum; 1992.
41.
Zurück zum Zitat Kalichman SC, Amaral CM, White D, Swetsze C, Kalichman MO, Cherry C, et al. Alcohol and adherence to antiretroviral medications: interactive toxicity beliefs among people living with HIV. J Assoc Nurses AIDS Care. 2012;23(6):511–20.CrossRefPubMedPubMedCentral Kalichman SC, Amaral CM, White D, Swetsze C, Kalichman MO, Cherry C, et al. Alcohol and adherence to antiretroviral medications: interactive toxicity beliefs among people living with HIV. J Assoc Nurses AIDS Care. 2012;23(6):511–20.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Kalichman SC, Amaral CM, White D, Swetsze C, Pope H, Kalichman MO, et al. Prevalence and clinical implications of interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapies among people living with HIV/AIDS. AIDS Patient Care STDs. 2009;23:449–54.CrossRefPubMedPubMedCentral Kalichman SC, Amaral CM, White D, Swetsze C, Pope H, Kalichman MO, et al. Prevalence and clinical implications of interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapies among people living with HIV/AIDS. AIDS Patient Care STDs. 2009;23:449–54.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Kalichman SC, Grebler T, Amaral CM, McNerey M, White D, Kalichman MO, et al. Intentional non-adherence to medications among HIV positive alcohol drinkers: prospective study of interactive toxicity beliefs. J Gen Intern Med. 2013;28(3):399–405.CrossRefPubMed Kalichman SC, Grebler T, Amaral CM, McNerey M, White D, Kalichman MO, et al. Intentional non-adherence to medications among HIV positive alcohol drinkers: prospective study of interactive toxicity beliefs. J Gen Intern Med. 2013;28(3):399–405.CrossRefPubMed
44.
Zurück zum Zitat Rosof EJ, Punzalan JC, Parsons JT. Adherence: how alcohol gets in the way. Elements of success: an International Conference on Adherence to Antiretroviral Therapy; Dallas, TX2004. Rosof EJ, Punzalan JC, Parsons JT. Adherence: how alcohol gets in the way. Elements of success: an International Conference on Adherence to Antiretroviral Therapy; Dallas, TX2004.
45.
Zurück zum Zitat Huynh AK, Kinsler JJ, Cunningham WE, Sayles JN. The role of mental health in mediating the relationship between social support and optimal ART adherence. AIDS Care. 2013;25(9):1179–84.CrossRefPubMedPubMedCentral Huynh AK, Kinsler JJ, Cunningham WE, Sayles JN. The role of mental health in mediating the relationship between social support and optimal ART adherence. AIDS Care. 2013;25(9):1179–84.CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Brown JL, Littlewood RA, Vanable PA. Social-cognitive correlates of antiretroviral therapy adherence among HIV-infected individuals receiving infectious disease care in a medium-sized northern U.S. city. AIDS Care. 2013;25(9):1149–58.CrossRefPubMedPubMedCentral Brown JL, Littlewood RA, Vanable PA. Social-cognitive correlates of antiretroviral therapy adherence among HIV-infected individuals receiving infectious disease care in a medium-sized northern U.S. city. AIDS Care. 2013;25(9):1149–58.CrossRefPubMedPubMedCentral
47.
Zurück zum Zitat Kunutsor S, Walley J, Katabira E, Muchuro S, Balidawa H, Namagala E, et al. Improving clinic attendance and adherence to antiretroviral therapy through a treatment supporter intervention in Uganda: a randomized controlled trial. AIDS Behav. 2011;15(8):1795–802.CrossRefPubMed Kunutsor S, Walley J, Katabira E, Muchuro S, Balidawa H, Namagala E, et al. Improving clinic attendance and adherence to antiretroviral therapy through a treatment supporter intervention in Uganda: a randomized controlled trial. AIDS Behav. 2011;15(8):1795–802.CrossRefPubMed
48.
Zurück zum Zitat Duwell MM, Knowlton AR, Nachega JB, Efron A, Goliath R, Morroni C, et al. Patient-nominated, community-based HIV treatment supporters: patient perspectives, feasibility, challenges, and factors for success in HIV-infected South African adults. AIDS Patient Care STDs. 2013;27(2):96–102.CrossRefPubMedPubMedCentral Duwell MM, Knowlton AR, Nachega JB, Efron A, Goliath R, Morroni C, et al. Patient-nominated, community-based HIV treatment supporters: patient perspectives, feasibility, challenges, and factors for success in HIV-infected South African adults. AIDS Patient Care STDs. 2013;27(2):96–102.CrossRefPubMedPubMedCentral
49.
Zurück zum Zitat Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, et al. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J Acquir Immune Defic Syndr. 2006;43(1):78–84.CrossRefPubMed Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, et al. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J Acquir Immune Defic Syndr. 2006;43(1):78–84.CrossRefPubMed
50.
Zurück zum Zitat Scanlon ML, Vreeman RC. Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings. HIV AIDS (Auckl). 2013;5:1–17.PubMedPubMedCentral Scanlon ML, Vreeman RC. Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings. HIV AIDS (Auckl). 2013;5:1–17.PubMedPubMedCentral
51.
Zurück zum Zitat Hussong AM. Further refining the stress-coping model of alcohol involvement. Addict Behav. 2003;28:1515–22.CrossRefPubMed Hussong AM. Further refining the stress-coping model of alcohol involvement. Addict Behav. 2003;28:1515–22.CrossRefPubMed
52.
Zurück zum Zitat Langebeek N, Gisolf EH, Reiss P, Vervoort SC, Hafsteinsdóttir TB, Richter C, et al. Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis. BMC Med. 2014;12:142.CrossRefPubMedPubMedCentral Langebeek N, Gisolf EH, Reiss P, Vervoort SC, Hafsteinsdóttir TB, Richter C, et al. Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis. BMC Med. 2014;12:142.CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Kekwaletswe CT, Morojele NK. Patterns and predictors of antiretroviral therapy use among alcohol drinkers at HIV clinics in Tshwane, South Africa. AIDS Care. 2014;26(Suppl 1):S78–82.CrossRefPubMed Kekwaletswe CT, Morojele NK. Patterns and predictors of antiretroviral therapy use among alcohol drinkers at HIV clinics in Tshwane, South Africa. AIDS Care. 2014;26(Suppl 1):S78–82.CrossRefPubMed
54.
Zurück zum Zitat Sankar A, Wunderlich T, Neufeld S, Luborsky M. Sero-positive African American’s beliefs about alcohol and their impact on anti-retroviral adherence. AIDS Behav. 2007;11(2):195–203.CrossRefPubMedPubMedCentral Sankar A, Wunderlich T, Neufeld S, Luborsky M. Sero-positive African American’s beliefs about alcohol and their impact on anti-retroviral adherence. AIDS Behav. 2007;11(2):195–203.CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat MacCallum RC, Austin JT. Applications of structural equation modeling in psychological research. Annu Rev Psychol. 2000;51:201–26.CrossRefPubMed MacCallum RC, Austin JT. Applications of structural equation modeling in psychological research. Annu Rev Psychol. 2000;51:201–26.CrossRefPubMed
56.
Zurück zum Zitat MacCallum RC, Wegener DT, Uchino BN, Fabrigar LR. The problem of equivalent models in applications of covariance structure analysis. Psychol Bull. 1993;114(1):185–99.CrossRefPubMed MacCallum RC, Wegener DT, Uchino BN, Fabrigar LR. The problem of equivalent models in applications of covariance structure analysis. Psychol Bull. 1993;114(1):185–99.CrossRefPubMed
57.
Zurück zum Zitat Dlamini PS, Wantland D, Makoae LN, Chirwa M, Kohi TW, Greeff M, et al. HIV stigma and missed medications in HIV-positive people in five African Countries. AIDS Patient Care STDs. 2009;23(5):377–87.CrossRefPubMedPubMedCentral Dlamini PS, Wantland D, Makoae LN, Chirwa M, Kohi TW, Greeff M, et al. HIV stigma and missed medications in HIV-positive people in five African Countries. AIDS Patient Care STDs. 2009;23(5):377–87.CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat Rao D, Feldman BJ, Fredericksen RJ, Crane PK, Simoni JM, Kitahata MM, et al. A structural equation model of HIV-related stigma, depressive symptoms, and medication adherence. AIDS Behav. 2012;16(3):711–6.CrossRefPubMedPubMedCentral Rao D, Feldman BJ, Fredericksen RJ, Crane PK, Simoni JM, Kitahata MM, et al. A structural equation model of HIV-related stigma, depressive symptoms, and medication adherence. AIDS Behav. 2012;16(3):711–6.CrossRefPubMedPubMedCentral
59.
Zurück zum Zitat Coetzee B, Kagee A, Vermeulen N. Structural barriers to adherence to antiretroviral therapy in a resource-constrained setting: the perspectives of health care providers. AIDS Care. 2011;23(2):146–51.CrossRefPubMed Coetzee B, Kagee A, Vermeulen N. Structural barriers to adherence to antiretroviral therapy in a resource-constrained setting: the perspectives of health care providers. AIDS Care. 2011;23(2):146–51.CrossRefPubMed
60.
Zurück zum Zitat Kagee A, Remien RH, Berkman A, Hoffman S, Campos L, Swartz L. Structural barriers to ART adherence in Southern Africa: challenges and potential ways forward. Glob Public Health. 2011;6(1):83–97.CrossRefPubMedPubMedCentral Kagee A, Remien RH, Berkman A, Hoffman S, Campos L, Swartz L. Structural barriers to ART adherence in Southern Africa: challenges and potential ways forward. Glob Public Health. 2011;6(1):83–97.CrossRefPubMedPubMedCentral
61.
Zurück zum Zitat Shisana O, Rehle T, Simbayi LC, Zuma K, Jooste S, Zungu N, et al. South African National HIV prevalence, incidence and behaviour survey, 2012. Cape Town: HSRC Press; 2014. Shisana O, Rehle T, Simbayi LC, Zuma K, Jooste S, Zungu N, et al. South African National HIV prevalence, incidence and behaviour survey, 2012. Cape Town: HSRC Press; 2014.
62.
Zurück zum Zitat Johnson LF. Access to antiretroviral treatment in South Africa, 2004-2011. S Afr J HIV Med. 2012;13(1):22–7.CrossRef Johnson LF. Access to antiretroviral treatment in South Africa, 2004-2011. S Afr J HIV Med. 2012;13(1):22–7.CrossRef
Metadaten
Titel
Social Support and the Mediating Roles of Alcohol Use and Adherence Self-Efficacy on Antiretroviral Therapy (ART) Adherence Among ART Recipients in Gauteng, South Africa
verfasst von
Connie T. Kekwaletswe
Esmé Jordaan
Sebenzile Nkosi
Neo K. Morojele
Publikationsdatum
11.11.2016
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 7/2017
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-016-1595-3

Weitere Artikel der Ausgabe 7/2017

AIDS and Behavior 7/2017 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.