Background
The mental health consequences of diabetes have been studied by a number of research teams and they have reported bidirectional associations between depression and type 2 diabetes [
1,
2]. In this study, we focused on the influence of type 2 diabetic associated problems on the presence of depressive symptoms. Based on the literature we classify these potential risk factors as sociodemographic, clinical, and psychosocial factors.
Several studies have shown that sociodemographic risk factors affect the development of co-morbid depression among diabetic patients. The prevalence rates of depression were significantly higher in females with type 2 diabetes mellitus compared with males with type 2 diabetes mellitus [
3‐
6], varying from a doubled percentage for women than for men [
7] and more than three times higher in women compared with men [
3]. Other sociodemographic risk factors that were significantly associated with depression in people with diabetes includes age at diabetes diagnosis [
8,
9], low socioeconomic status [
3,
4,
6,
10], low educational status [
1,
3,
4], being unmarried [
1,
4,
9], urban dwelling [
3], nature of relationship with sexual partners [
11], ethnicity/race [
12,
13], smoking habits [
14‐
16], physical activity [
14], sedentary life [
8], and unemployment [
17]. Some other studies, however, found that gender, age, residence, educational status, ethnicity, marital status, employment status, and socioeconomic status had no significant association with depression in diabetes patients [
11,
17‐
19].
The effects of clinical and psychosocial factors on co-morbid depression have been supported by different studies as well. These factors encompass financial stress [
1,
19,
20], poor social support [
1,
4], negative life events [
1,
19,
20], poor quality of life [
20,
21], and medication burden [
19,
22].
Depression was most strongly associated with functional impairment [
1], large waist circumference [
19], glycosylated hemoglobin level [
1,
3], body mass index [
7,
12], blood glucose level [
3], diabetic retinopathy [
23], diabetic neuropathy [
1,
12,
19,
23], diabetic nephropathy [
19,
23], peripheral vascular disease [
19,
23], diabetic foot ulcer [
19], coronary vascular disease [
23], ischemic heart disease [
16,
23], arteriosclerotic vascular disease [
23], heart disorder [
3], type of diabetic treatment [
3,
24], and sexual dysfunction [
23]. On the contrary depression was not significantly associated with poor body weight control, insulin treatment users, duration of diabetes, glycosylated hemoglobin (HbA1c), obesity, hypertensive disorder, retinopathy [
3,
12,
17,
18].
The major barriers in diagnosing depression among type 2 diabetic patients were the lack of screening tool, time constraints, and overlapping of physical and cognitive symptoms [
3,
25].
Thus, there are various sociodemographic, clinical, and psychosocial factors related to depression in type 2 diabetes mellitus. Identifying the significant predictors of depression is important to develop need-based clinical and community-based mental health interventions. Although these factors have been found to be associated with depression, most of these studies were based on Western samples, with only some exceptions. Therefore, we do not know whether these findings can be generalized to a non-western setting. Thus in the present study, we aimed to identify factors influencing the risk of co-morbid depression among patients with type 2 diabetes mellitus in patients treated at the Black Lion General Specialized Hospital in Ethiopia. We hypothesized that the same identified factors were associated with depression in this non-western sample.
Discussion
In the general diabetic population, it is difficult to accurately estimate the potential medical care needs and public health burdens of depression [
28]. Unfortunately, in spite of the high impact of depression and diabetes comorbidity on the individual and its importance as a public health problem, little is known about the existence of depression in people with diabetes in Ethiopia. To our knowledge, this is the first study to assess sociodemographic, clinical, and psychosocial factors related to type 2 diabetes mellitus causing depression in a large sample. This study has tried to address this issue by identifying factors associated with depression in type 2 diabetic outpatients.
In this study low family monthly income was the significant independent predictor of depression. This result was consistent with other studies report [
3,
4,
6,
10].
We found that sex, residence, marital status, ethnicity, educational status, waist circumference, current age, and age at diagnosis were not associated factors for depression. This study finding was also in line with several previous studies [
11,
14,
17,
27].
However, many earlier published articles reported the prevalence rates of depression were significantly higher in females with type 2 diabetes mellitus compared with males with type 2 diabetes mellitus [
3‐
5,
8‐
11]. Other demographic risk factors that were significantly associated in varying degree with depression in people with diabetes includes age at diabetes diagnosis [
8,
9], low educational level [
1,
3,
4], being unmarried [
1,
4,
7], urban residence [
3], nature of relationship with sexual partners [
11], ethnicity/race [
12,
13], smoking habits [
14‐
16], physical activity [
14], sedentary life [
8], and unemployment [
17]. This discrepancy was might be due to variation in study design, demographic characteristics of respondents, and selection method of respondents.
Regarding the clinical characteristics of participants, earlier studies conducted in different setting revealed depression was most strongly associated with large waist circumference [
19], body mass index [
7,
12], blood sugar level [
3], diabetic retinopathy [
23], diabetic neuropathy [
1,
12,
19,
23], diabetic nephropathy [
19,
23], peripherovascular disease [
19,
23], diabetic foot ulcer [
19], coronary vascular disease [
23], ischemic heart disease [
16,
23], arteriosclerotic vascular disease [
23], heart disorder [
3], type of diabetic treatment [
3,
24], and sexual dysfunction [
23].
Similarly, the result of this study demonstrated a significantly higher prevalence of depression in type 2 diabetic outpatients with the presence of ≥3 diabetic complication and diabetic nephropathy.
On the contrary depression was not significantly associated with diabetes treatment regimen co-morbid disease (cardiovascular, respiratory, renal, neurologic), complication of diabetes (retinopathy, neuropathy, sexual dysfunction), duration of diabetes, duration of diabetes treatment, fasting blood sugar, body mass index, number of co-morbidity, number of prescribed medication administration per day, and physical disability. This variation might be due to the level of country development, time frame, study setting, and lifestyle variation.
Moreover, we found out negative life events and poor social support were a statistically significantly psychosocial risk factor for depression. In line with this study the psychosocial factors that had a significant association with co-morbid depression comprises poor social support [
2,
4] and experience chronic stressors or negative life events [
2,
14,
17].
Previous studies also support increased health care costs/financial stress [
2,
14,
20] and pill burden [
14,
24] were associated factors for depression. Disparately, in this study high health care cost and medication burden were not associated with depression.
The outcomes of this study have implications for health care practice in Black Lion General Specialized Hospital and other health care organizations, where clinician’s diagnosis of psychiatric disorders rate is inadequate because of the high patient load, lack of screening tool, and poor undergraduate or in-service training in these skills. Principally this study has a presumption that the burden of mental health especially depression is high in the population with type 2 diabetes mellitus co-morbidity and requires attention to diagnose early and treat promptly. Laboratory test results and pharmacological treatment plan are not adequate to scaling up service delivery and bring about the expected change.
Limitations and strengths
The strengths of this study include a high response rate and the inclusive nature of this research as individuals could participate regardless of literacy level. Including patients from different ethnic backgrounds in Addis Ababa and outside Addis Ababa was a further strength. Additionally, rather than having to rely on self-report, health-related information was collected from patients’ medical records. Even though the association was temporary, depression and type 2 diabetes mellitus were causally related and deserves attention from clinicians to ensure better management. Also, a reasonable sample size and ascertaining depression with culturally standardized questionnaires are strengths of this study. Since it was the first study in type, it will provide basic information for those who are interested.
However, an important limitation of this study was that a psychiatric diagnostic interview which is considered as the gold standard for the diagnosis of depression was not used. Additionally, there was an absence of similar study done in Ethiopia health care setting to compare the finding. Moreover, due to cross-sectional nature of the study, causal relationships between depression and type 2 diabetes mellitus cannot be assumed.
Conclusion
In conclusion, this study demonstrated that depression is a common co-morbid health problem in type 2 diabetic out-patients in Black Lion General Specialized Hospital with a prevalence rate of 44.7 %. Within this sample of outpatients with type 2 diabetes mellitus, the study found that low monthly family income, presence of ≥3 diabetic complications, diabetic nephropathy, negative life event, and poor social support were highly statistically significant risk factors associated with depression. All the result should be interpreted cautiously and further prospective longitudinal research focusses on these sociodemographic and clinical factors in the different clinical group should be conducted. Finally, we presumed the burden of mental health especially depression is high in the population with type 2 diabetes mellitus co-morbidity and requires attention to diagnose early and treat promptly.
Ethics approval and consent to participate
In order to follow the ethical and legal standards of the scientific investigation, the study was conducted after the approval of the proposal by Addis Ababa University Institutional Review Board. Participation was voluntary and information was collected anonymously after obtaining written consent from each respondent by assuring confidentiality throughout the data collection period.
Consent for publication
Not applicable.
Availability of data and materials
The data is available to the concerned body when it is required.
Acknowledgement
We would like to address our sincerest and heart –felt gratitude to our advisor Yoseph Tsige (Associate professor) and Dr. Abdurazak Ahmed (MD) for their concrete and expert advice, suggestions, and assistance in all aspects of this research work.
Our in-depth gratitude also goes to Addis Ababa University, College of Health Science, School of Allied Health science, Department of Nursing and Midwifery, for giving this chance and approval of the study too.
We would like to thank Dr. Yewondweson Tadesse, department head of Internal Medicine; Dr. Tedilla Kebede, Physicians coordinator in diabetes clinic; Sr. Abeba Mulugeta, Nurses coordinator in the diabetic clinic; in Black Lion General Specialized Hospital for their collaboration to permit and facilitate data collection.
Supervisors, data collectors, and respondents were highly acknowledged for investing their precious time in supervising, collecting data and providing the necessary information.
We would like to offer our great respect and appreciation to all our friends and senior instructors who gave us precious time for advice and comments during data entry and analysis.
Competing interest
The authors declare that there is no conflict of interests regarding the publication of this research article.
Authors’ contributions
TD conceived and designed the study. SM supervised data collection and analyzed the data. YG drafted the manuscript. Additionally, all the authors read the manuscript several times and have given final approval of the version to be published.