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Erschienen in: Endocrine 2/2020

13.04.2020 | Meta-Analysis

Socioeconomic differences in hyperuricemia and gout: a systematic review and meta-analysis

verfasst von: Zhe Pan, Mingkai Huang, Ming Fang, Xu Xie, Ze Huang

Erschienen in: Endocrine | Ausgabe 2/2020

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Abstract

Purpose

There are multiple risk factors have different influence on the disorder. However, the risk of hyperuricemia and gout in different socioeconomic status (SES) remains unclear. Recent studies provided results that contradicted to former studies. We aimed to perform a systematic review and meta-analysis of evidence to date and to assess the associations between SES and hyperuricemia or gout worldwide.

Methods

We searched MEDLINE, EMBASE, and Web of Science databases to identify studies that investigated the association between SES and hyperuricemia or gout. Studies that presented risk estimates were included. We conducted meta-analyses using random effects to combine unadjusted and adjusted effect estimates.

Results

Data from 14 studies were included, 9 provided data about hyperuricemia and 5 provided gout. Overall, there was an association between higher educational level and a higher risk of hyperuricemia (POR = 1.38, 95% CI 1.04–1.73) but lower risk of gout (POR = 0.59, 95% CI 0.47–0.71). Subgroup meta-analysis showed no association between all SES measures and hyperuricemia or gout in males or females.

Conclusions

Our study suggested that the associations between SES and hyperuricemia gout are different. Higher educational level was related to a higher risk of hyperuricemia but lower risk of gout. Given the limitations of our study, future studies are needed to investigate specific mechanisms underlying the relationship among SES differences in hyperuricemia and gout. Strategies to prevent and control SES inequalities in hyperuricemia and gout should be explored and adopted.
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Metadaten
Titel
Socioeconomic differences in hyperuricemia and gout: a systematic review and meta-analysis
verfasst von
Zhe Pan
Mingkai Huang
Ming Fang
Xu Xie
Ze Huang
Publikationsdatum
13.04.2020
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2020
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-020-02281-w

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