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Erschienen in: Critical Care 3/2011

01.06.2011 | Letter

Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?

verfasst von: Pieter R Tuinman, Nicole P Juffermans

Erschienen in: Critical Care | Ausgabe 3/2011

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Excerpt

Dr Lorente and colleagues [1] report on the interesting association between serum soluble CD40 ligand (sCD40L) levels and mortality in patients with sepsis. Some variables that can influence outcome in sepsis were accounted for in their analysis. However, the amount of transfused blood products, which may influence levels of sCD40L, was not reported. …
Literatur
1.
Zurück zum Zitat Lorente L, Martín MM, Varo N, Borreguero-León JM, Solé-Violán J, Blanquer J, Labarta L, Díaz C, Jiménez A, Pastor E, Belmonte F, Orbe J, Rodríguez JA, Gómez-Melini E, Ferrer-Agüero JM, Ferreres J, Llimiñana MC, Páramo JA: Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care 2011, 15: R97. 10.1186/cc10104PubMedCentralCrossRefPubMed Lorente L, Martín MM, Varo N, Borreguero-León JM, Solé-Violán J, Blanquer J, Labarta L, Díaz C, Jiménez A, Pastor E, Belmonte F, Orbe J, Rodríguez JA, Gómez-Melini E, Ferrer-Agüero JM, Ferreres J, Llimiñana MC, Páramo JA: Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care 2011, 15: R97. 10.1186/cc10104PubMedCentralCrossRefPubMed
2.
Zurück zum Zitat Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood 2006, 108: 2455-2462. 10.1182/blood-2006-04-017251PubMedCentralCrossRefPubMed Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood 2006, 108: 2455-2462. 10.1182/blood-2006-04-017251PubMedCentralCrossRefPubMed
3.
Zurück zum Zitat Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP: The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res 2009, 45: 251-260. 10.1007/s12026-009-8106-9CrossRefPubMed Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP: The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res 2009, 45: 251-260. 10.1007/s12026-009-8106-9CrossRefPubMed
4.
Zurück zum Zitat Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36: 2667-2674. 10.1097/CCM.0b013e3181844677CrossRefPubMed Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36: 2667-2674. 10.1097/CCM.0b013e3181844677CrossRefPubMed
5.
Zurück zum Zitat Juffermans NP, Prins DJ, Vlaar AP, Nieuwland R, Binnekade JM: Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study. Shock 2011, 35: 355-359. 10.1097/SHK.0b013e3182086094CrossRefPubMed Juffermans NP, Prins DJ, Vlaar AP, Nieuwland R, Binnekade JM: Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study. Shock 2011, 35: 355-359. 10.1097/SHK.0b013e3182086094CrossRefPubMed
6.
Zurück zum Zitat Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B, Thorlacius H: Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg 2009, 250: 783-790. 10.1097/SLA.0b013e3181bd95b7CrossRefPubMed Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B, Thorlacius H: Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg 2009, 250: 783-790. 10.1097/SLA.0b013e3181bd95b7CrossRefPubMed
Metadaten
Titel
Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?
verfasst von
Pieter R Tuinman
Nicole P Juffermans
Publikationsdatum
01.06.2011
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 3/2011
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10237

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