Skip to main content
main-content

19.01.2017 | Retinal Disorders | Ausgabe 5/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 5/2017

Soluble form of LR11 is highly increased in the vitreous fluids of patients with idiopathic epiretinal membrane

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 5/2017
Autoren:
Ryuya Hashimoto, Meizi Jiang, Tomoaki Shiba, Nobuyuki Hiruta, Mao Takahashi, Morihiro Higashi, Yuichi Hori, Hideaki Bujo, Takatoshi Maeno

Abstract

Purpose

LR11 (also called SorLA or SORL1) is a migration regulator of adherent cells with the immature proliferative phenotype. The present study investigated the clinical and pathological involvement of the soluble form of LR11 (sLR11) in the idiopathic epiretinal membrane (iERM).

Methods

The subjects were 51 patients with iERM (24 cellophane macular reflex (CMR) and 27 preretinal macular fibrosis (PMF)) and 45 patients with macular holes as age and sex-matched controls. Vitreous sLR11 and transforming growth factor (TGF)β2 levels were measured by ELISA.

Results

The sLR11 levels in the vitreous fluids of patients with iERM (20.2 ± 8.1 ng/mL) were significantly higher than those in controls (11.4 ± 4.7 ng/mL). Among the patients with iERM, the vitreous sLR11 levels were significantly higher in PMF (23.6 ± 8.2 ng/mL), than those in CMR (16.5 ± 5.9 ng/mL). Multivariate regression analysis of the studied factors showed that sLR11 was a unique factor independently contributing to the discrimination of the iERM patients against the control subjects (odds ratio [OR] 1.35 per 1-ng/mL increase, 95% CI 1.09–1.67; P = 0.004). ROC analysis showed that the sensitivity and the specificity of sLR11, but not of other studied factors, categorized into the rank of moderate accuracy. Finally, there was a positive correlation (R = 0.588; P = 0.003) between the vitreous levels of sLR11 and TGFβ2 using the available samples.

Conclusions

sLR11 levels in vitreous fluids were specifically increased in patients with iERM, suggesting the involvement in the pathology of proliferative and migrating cells for the development of iERM.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 5/2017 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

07.09.2018 | Video plus | Ausgabe 11/2018

Einseitige kombinierte Augenmuskeloperation zur Korrektur der Esotropie

Videobeitrag zur Rücklagerung des M. rectus medialis und Faltung des M. rectus lateralis

24.08.2018 | Leitlinien, Stellungnahmen und Empfehlungen | Ausgabe 10/2018

Stellungnahme von BVA, DOG und RG zur intravitrealen Therapie des visusmindernden Makulaödems bei retinalem Venenverschluss

Therapeutische Strategien, Stand 24.04.2018

20.08.2018 | Rehabilitation | CME | Ausgabe 10/2018 Open Access

Aktuelle Möglichkeiten der visuellen Rehabilitation

17.08.2018 | Das therapeutische und diagnostische Prinzip | Ausgabe 11/2018

Suprachoroidale Hydrogelplombe