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Journal of Neuro-Oncology
Erschienen in:

23.07.2024 | Review

Sonodynamic therapy for adult-type diffuse gliomas: past, present, and future

verfasst von: Sydney E. Scanlon, Regan M. Shanahan, Othman Bin-Alamer, Alexandros Bouras, Milena Mattioli, Sakibul Huq, Constantinos G. Hadjipanayis

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2024

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Abstract

Background

Intra-axial brain tumors persist as significant clinical challenges. Aggressive surgical resection carries risk of morbidity, and the blood-brain barrier (BBB) prevents optimal pharmacological interventions. There is a clear clinical demand for innovative and less invasive therapeutic strategies for patients, especially those that can augment established treatment protocols. Focused ultrasound (FUS) has emerged as a promising approach to manage brain tumors. Sonodynamic therapy (SDT), a subset of FUS, utilizes sonosensitizers activated by ultrasound waves to generate reactive oxygen species (ROS) and induce tumor cell death.

Objective

This review explores the historical evolution and rationale behind SDT, focusing on its mechanisms of action and potential applications in brain tumor management.

Method

A systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

Preclinical studies have demonstrated the efficacy of various sonosensitizers, including 5-aminolevulinic acid (5-ALA), fluorescein, porphyrin derivatives, and nanoparticles, in conjunction with FUS for targeted tumor therapy and BBB disruption. Clinical trials have shown promising results in terms of safety and efficacy, although further research is needed to fully understand the potential adverse effects and optimize treatment protocols. Challenges such as skull thickness affecting FUS penetration, and the kinetics of BBB opening require careful consideration for the successful implementation of SDT in clinical practice. Future directions include comparative studies of different sonosensitizers, optimization of FUS parameters, and exploration of SDT’s immunomodulatory effects.

Conclusion

SDT represents a promising frontier in the treatment of aggressive brain tumors, offering hope for improved patient outcomes.
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Metadaten
Titel
Sonodynamic therapy for adult-type diffuse gliomas: past, present, and future
verfasst von
Sydney E. Scanlon
Regan M. Shanahan
Othman Bin-Alamer
Alexandros Bouras
Milena Mattioli
Sakibul Huq
Constantinos G. Hadjipanayis
Publikationsdatum
23.07.2024
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 3/2024
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-024-04772-6

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