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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

11.05.2022 | Editorial

Spatial density and tumor dosimetry are important in radiation segmentectomy with ⁹⁰Y glass microspheres

verfasst von: Carlo Chiesa, Stefania Mazzaglia, Marco Maccauro

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2022

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The aim of the retrospective two-arms study by the Mayo Clinic group under focus here [ 1] is the optimization of segmentectomy, which means treating a maximum of two liver segments with radioactive microspheres. Authors considered patients treated for hepato-cellular carcinoma (HCC) with ⁹⁰Y glass microspheres as neo-adjuvant therapy before transplantation. The intriguing work was split in two analyses. …

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Spreafico C, Maccauro M, Mazzaferro V, Chiesa C. The dosimetric importance of the number of 90Y microspheres in liver transarterial radioembolization (TARE). Eur J Nucl Med Mol Imaging. 2014;41:634–8. https://doi.org/10.1007/s00259-013-2674-6. CrossRefPubMed

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Romanò C, Mazzaglia S, Maccauro M, Spreafico C, et al. Radioembolization of hepatocellular carcinoma with 90Y glass microspheres: no advantage of voxel dosimetry with respect to mean dose in dose-response analysis with two radiological methods. Cancers. 2022;14(4):959. https://doi.org/10.3390/cancers14040959. CrossRefPubMedPubMedCentral

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Walrand S, Hesse M, Chiesa C, Lhommel R. Jamar F The low hepatic toxicity per Gy of 90Y glass microspheres is linked to their transport in the arterial tree favouring a non uniform trapping as observed in posttherapy PET imaging. J Nucl Med. 2014;55:135–40. https://doi.org/10.2967/jnumed.113.126839. CrossRefPubMed

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Chiesa C, Sjogreen-Gleisner K, Walrand S, Strigari L, et al. EANM dosimetry committee series on standard operational procedures: a unified methodology for (99m)Tc-MAA pre- and (90)Y peri-therapy dosimetry in liver radioembolization with (90)Y microspheres. Eur J Nucl Med Mol Imaging Phys. 2021;8:77. https://doi.org/10.1186/s40658-021-00394-3. CrossRef

11.

Salem R, Padia SA, Lam M, Bell J, et al. Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging. 2019;46(8):1695–704. https://doi.org/10.1007/s00259-019-04340-5. CrossRefPubMed

Titel: Spatial density and tumor dosimetry are important in radiation segmentectomy with 90Y glass microspheres
verfasst von: Carlo Chiesa
Stefania Mazzaglia
Marco Maccauro
Publikationsdatum: 11.05.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05819-4

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Spatial density and tumor dosimetry are important in radiation segmentectomy with ⁹⁰Y glass microspheres

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